p87PIKAP
{{Short description|Mammalian protein found in Homo sapiens}}
{{infobox protein
|Name=Phosphoinositide-3-kinase adapter protein of 87 kDa
|caption=
|image=
|width=
|HGNCid=27101
|Symbol=p87PIKAP
|AltSymbols=p84,PIK3R6
|EntrezGene=146850
|UniProt=Q5UE93
|OMIM=611462
|PDB=
|ECnumber=
|Chromosome=17
|Arm=p
|Band=13.1
|LocusSupplementaryData=
}}
Within molecular and cell biology, p87PIKAP is a regulatory subunit of the type IB Phosphoinositide 3-Kinase p110γ that is highly expressed in the heart and is present in dendritic cells, macrophages, and neutrophils.{{cite journal | vauthors = Voigt P, Dorner MB, Schaefer M | title = Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B | journal = The Journal of Biological Chemistry | volume = 281 | issue = 15 | pages = 9977–86 | year = 2006 | pmid = 16476736 | doi = 10.1074/jbc.M512502200 | doi-access = free }}
It is also referred to as p84 and p87.{{cite journal | vauthors = Kurig B, Shymanets A, Bohnacker T, Prajwal, Brock C, Ahmadian MR, Schaefer M, Gohla A, Harteneck C, Wymann MP, Jeanclos E, Nürnberg B | display-authors = 6 | title = Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 106 | issue = 48 | pages = 20312–7 | year = 2009 | pmid = 19906996 | pmc = 2787109 | doi = 10.1073/pnas.0905506106 | bibcode = 2009PNAS..10620312K | doi-access = free }} Some studies have found P87PIKAP to have a role in carcinogenesis.{{cite journal|title=Differential roles for the p101 and p84 regulatory subunits of PI3Kc in tumor growth and metastasis|url=https://www.nature.com/onc/journal/v31/n18/pdf/onc2011414a.pdf?origin=ppub|first1=JA |last1=Brazzatti|display-authors=etal|journal=Oncogene|date=2012|volume=31|issue = 18|pages=2350–2361|doi=10.1038/onc.2011.414|pmid = 21996737|s2cid = 24708435|doi-access=free}}
