panobacumab

{{short description|Monoclonal antibody designed as an antibacterial against Pseudomonas aeruginosa}}

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| type = mab

| mab_type = mab

| source = u

| target = Pseudomonas aeruginosa serotype IATS O11

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| CAS_number_Ref = {{cascite|changed|??}}

| CAS_number = 885053-97-4

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| UNII = 62B4OXU259

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| C=38714 | H=60189 | N=10637 | O=12187 | S=322

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Panobacumab (proposed INN) is a monoclonal antibody designed as an antibacterial against Pseudomonas aeruginosa.[https://www.who.int/entity/medicines/publications/druginformation/innlists/PL100prepubli.pdf International Nonproprietary Names for Pharmaceutical Substances (INN, prepublication copy)], World Health Organization.

It is a fully human pentameric IgM antibody with a mouse J chain.

Image:IgM.pngs.
3: Light chains.
4: J chain.
5: Intermolecular disulfide bonds.]]

Development

Panobacumab is being developed by Aridis Pharmaceuticals. As of November 15th it is in phase 2 clinical trials. The originator was Berna Biotech.{{cite web |url=https://adisinsight.springer.com/drugs/800024401 |accessdate=15 November 2019|title=Panobacumab - Aridis Pharmaceuticals - AdisInsight}}

The mechanism of action is as a lipopolysaccharide inhibitor.

References

{{Monoclonals for infectious disease and toxins}}

Category:Monoclonal antibodies

Category:Experimental monoclonal antibodies

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