parathyroid hormone receptor

{{Short description|none}}

{{infobox protein

| Name = parathyroid hormone 1 receptor

| caption =

| image =

| width =

| HGNCid = 9608

| Symbol = PTH1R

| AltSymbols = PTHR, PFE

| EntrezGene = 5745

| OMIM = 168468

| RefSeq = NM_000316

| UniProt = Q03431

| PDB =

| ECnumber =

| Chromosome = 3

| Arm = p

| Band = 22

| LocusSupplementaryData = -p21.1

}}

{{infobox protein

| Name = parathyroid hormone 2 receptor

| caption =

| image =

| width =

| HGNCid = 9609

| Symbol = PTH2R

| AltSymbols =

| EntrezGene = 5746

| OMIM = 601469

| RefSeq = NM_005048

| UniProt = P49190

| PDB =

| ECnumber =

| Chromosome = 2

| Arm = q

| Band = 33

| LocusSupplementaryData =

}}

There are two known parathyroid hormone receptors in mammals termed PTH1R and PTH2R. These receptors bind parathyroid hormone and are members of the GPCR family of transmembrane proteins.{{cite journal | author = Jüppner H | title = Molecular cloning and characterization of a parathyroid hormone/parathyroid hormone-related peptide receptor: a member of an ancient family of G protein-coupled receptors | journal = Curr. Opin. Nephrol. Hypertens. | volume = 3 | issue = 4 | pages = 371–8 | year = 1994 | pmid = 8076140 | doi = 10.1097/00041552-199407000-00002 }}

• parathyroid hormone 1 receptor (PTH1R) is the classical PTH receptor, is expressed in high levels in bone and kidney and regulates calcium ion homeostasis through activation of adenylate cyclase and phospholipase C.{{cite journal | vauthors = Mannstadt M, Jüppner H, Gardella TJ | title = Receptors for PTH and PTHrP: their biological importance and functional properties | journal = Am. J. Physiol. | volume = 277 | issue = 5 Pt 2 | pages = F665–75 | year = 1999 | pmid = 10564229 | doi = 10.1152/ajprenal.1999.277.5.F665| url = http://ajprenal.physiology.org/cgi/content/abstract/277/5/F665 | access-date = 2007-11-01 | archive-url = https://web.archive.org/web/20090213101535/http://ajprenal.physiology.org/cgi/content/abstract/277/5/F665 | archive-date = 2009-02-13 | url-status = dead }}{{cite journal |vauthors=Offermanns S, Iida-Klein A, Segre GV, Simon MI | title = G alpha q family members couple parathyroid hormone (PTH)/PTH-related peptide and calcitonin receptors to phospholipase C in COS-7 cells | journal = Mol. Endocrinol. | volume = 10 | issue = 5 | pages = 566–74 | year = 1996 | doi = 10.1210/mend.10.5.8732687 | pmid = 8732687 | doi-access = free }}
• parathyroid hormone 2 receptor (PTH2R) is expressed primarily in the central nervous system, pancreas, testis, and placenta.{{cite journal |vauthors=Usdin TB, Bonner TI, Hoare SR | title = The parathyroid hormone 2 (PTH2) receptor | journal = Recept. Channels | volume = 8 | issue = 3–4 | pages = 211–8 | year = 2002 | pmid = 12529938 | doi = 10.1080/10606820213682 }}