peripheral odontogenic fibroma

{{Infobox medical condition

|name = Peripheral odontogenic fibroma

|synonyms = PFO

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Peripheral odontogenic fibroma (PFO) is a fibrous connective tissue mass that is exophytic and covered in surface epithelium that contains odontogenic epithelium.{{cite journal | last1=MARTELLI‐JÚNIOR | first1=H. | last2=MESQUITA | first2=R. A. | last3=DE PAULA | first3=A. M. B. | last4=PÊGO | first4=S. P. B. | last5=SOUZA | first5=L. N. | title=Peripheral odontogenic fibroma (WHO type) of the newborn: a case report | journal=International Journal of Paediatric Dentistry | publisher=Wiley | volume=16 | issue=5 | year=2006 | issn=0960-7439 | doi=10.1111/j.1365-263x.2006.00738.x | pages=376–379| pmid=16879337 }} The World Health Organization (WHO) classifies peripheral odontogenic fibroma as a fibroblastic neoplasm with variable amounts of odontogenic epithelium that appears to be dormant. Dentine and/or cementum-like material may be present.{{cite book | last1=Kramer | first1=I. R. H. | last2=Pindborg | first2=J. J. | last3=Shear | first3=M. | title=Histological Typing of Odontogenic Tumours | chapter=Histological Classification of Odontogenic Tumours | publisher=Springer Berlin Heidelberg | publication-place=Berlin, Heidelberg | date=1992 | isbn=978-3-540-54142-4 | doi=10.1007/978-3-662-02858-2_2 | page=7–9}}

Signs and symptoms

Peripheral odontogenic fibroma manifests clinically as an infrequent, benign, unencapsulated exophytic mass that can be sessile or pedunculated, red or pink, smooth-surfaced, and ulcerated in some cases. It is frequently found on the attached gingiva, mainly in the molar and premolar regions, though it can be found anywhere in the jaw.{{cite journal | last1=Nikam | first1=ShitalSudhakar | last2=Gadgil | first2=RajeevM | last3=Bhoosreddy | first3=AjayR | last4=Shah | first4=KaranR | title=Peripheral odontogenic fibroma: A case report and review of literature | journal=Journal of Indian Academy of Oral Medicine and Radiology | publisher=Medknow | volume=27 | issue=1 | year=2015 | issn=0972-1363 | doi=10.4103/0972-1363.167138 | page=140 |doi-access=free}}

Diagnosis

Clinically, there is no way to differentiate peripheral odontogenic fibroma from other common fibrous gingival lesions,{{cite journal | last1=Baiju | first1=CS | last2=Rohatgi | first2=Sumidha | title=Peripheral odontogenic fibroma: A case report and review | journal=Journal of Indian Society of Periodontology | publisher=Medknow | volume=15 | issue=3 | year=2011 | issn=0972-124X | doi=10.4103/0972-124x.85674 | page=273 | doi-access=free | pmc=3200026 }} including peripheral giant cell lesion, pyogenic granuloma, inflammatory fibrous hyperplasia, and peripheral ossifying fibroma.{{cite journal |last1=Patel |first1=Stavan |last2=Vakkas |first2=John |last3=Mandel |first3=Louis |title=Recurrent peripheral odontogenic fibroma. Case report |journal=The New York State Dental Journal |date=2011 |volume=77 |issue=4 |pages=35–37 |pmid=21894830}} Rarely have diffuse or multifocal lesions been reported. Lesions that are larger may show signs of mineralization, although radiographic changes are uncommon, particularly in the early stages. Histopathologic features include a proliferation of relatively cellular fibrous or fibromyxomatous connective tissue with variable amounts of odontogenic epithelium and occasionally foci of calcification in the form of dentinoid, cementicles, or bone. These features are similar to those of the central odontogenic fibroma.{{cite journal | last=Gardner | first=David G. | title=The peripheral odontogenic fibroma: An attempt at clarification | journal=Oral Surgery, Oral Medicine, Oral Pathology | publisher=Elsevier BV | volume=54 | issue=1 | year=1982 | issn=0030-4220 | doi=10.1016/0030-4220(82)90415-7 | pages=40–48}}

Treatment

The preferred course of treatment is conservative local excision.{{cite journal | last=Eversole | first=Lewis R. | title=Odontogenic Fibroma, Including Amyloid and Ossifying Variants | journal=Head and Neck Pathology | publisher=Springer Science and Business Media LLC | volume=5 | issue=4 | date=July 13, 2011 | issn=1936-055X | doi=10.1007/s12105-011-0279-6 | pages=335–343| pmid=21751042 | pmc=3210224 }}

Outlook

The rate of recurrence varies wildly. According to some studies, peripheral odontogenic fibroma has a low recurrence rate.{{cite journal | last1=Slabbert | first1=Hein de Villiers | last2=Altini | first2=Mario | title=Peripheral odontogenic fibroma: A clinicopathologic study | journal=Oral Surgery, Oral Medicine, Oral Pathology | publisher=Elsevier BV | volume=72 | issue=1 | year=1991 | issn=0030-4220 | doi=10.1016/0030-4220(91)90195-i | pages=86–90}} One study showed a recurrence rate of 38.9%,{{cite journal | last1=Daley | first1=Tom D. | last2=Wysocki | first2=George P. | title=Peripheral odontogenic fibroma | journal=Oral Surgery, Oral Medicine, Oral Pathology | publisher=Elsevier BV | volume=78 | issue=3 | year=1994 | issn=0030-4220 | doi=10.1016/0030-4220(94)90064-7 | pages=329–336| pmid=7970594 }} while another study showed a recurrence rate of 50%.{{cite journal | last1=Ritwik | first1=Priyanshi | last2=Brannon | first2=Robert B. | title=Peripheral odontogenic fibroma: a clinicopathologic study of 151 cases and review of the literature with special emphasis on recurrence | journal=Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology | publisher=Elsevier BV | volume=110 | issue=3 | year=2010 | issn=1079-2104 | doi=10.1016/j.tripleo.2010.04.018 | pages=357–363| pmid=20674403 }}

Epidemiology

The literature has reported a slight female predominance in this neoplasm, which occurs in a wide age range from the first to the ninth decades of life with a peak in the second and fourth decades.{{cite journal |last1=Garcia |first1=BG |last2=Johann |first2=ACBR |last3=da Silveira-Júnior |first3=JB |last4=Aguiar |first4=MC |last5=Mesquita |first5=RA |title=Retrospective analysis of peripheral odontogenic fibroma (WHO-type) in Brazilians |journal=Minerva Stomatologica |date=March 2007 |volume=56 |issue=3 |pages=115–119 |pmid=17327815 |url=https://www.minervamedica.it/en/journals/minerva-dental-and-oral%20science/article.php?cod=R18Y2007N03A0115 |access-date=19 December 2023}}

References

External links

[https://dermnetnz.org/topics/peripheral-odontogenic-fibroma DermNet]
[https://www.pathologyoutlines.com/topic/mandiblemaxillaodontogenicfibroma.html Odontogenic fibroma] at [https://www.pathologyoutlines.com/ Pathology Outlines].

{{Medical resources

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Category:Periodontal disorders

Category:Odontogenic tumors