phenindione

{{Short description|Chemical compound}}

{{Drugbox

| verifiedrevid = 464200313

| IUPAC_name = 2-phenyl-1H-indene-1,3(2H)-dione

| image = Phenindione.svg

| tradename =

| Drugs.com = {{drugs.com|international|phenindione}}

| pregnancy_AU = D

| pregnancy_US =

| pregnancy_category = Passes into breast milk

| legal_AU =

| legal_UK =

| legal_US =

| legal_status =

| routes_of_administration = Oral

| bioavailability =

| protein_bound = 88%

| metabolism =

| elimination_half-life = 5 to 10 hours

| excretion =

| IUPHAR_ligand = 6838

| CAS_number_Ref = {{cascite|correct|??}}

| CAS_number = 83-12-5

| ATC_prefix = B01

| ATC_suffix = AA02

| ATC_supplemental =

| PubChem = 4760

| DrugBank_Ref = {{drugbankcite|correct|drugbank}}

| DrugBank = DB00498

| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}

| ChemSpiderID = 4596

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = 5M7Y6274ZE

| KEGG_Ref = {{keggcite|correct|kegg}}

| KEGG = D08354

| ChEBI_Ref = {{ebicite|correct|EBI}}

| ChEBI = 8066

| ChEMBL_Ref = {{ebicite|correct|EBI}}

| ChEMBL = 711

| C=15 | H=10 | O=2

| smiles = O=C2c1ccccc1C(=O)C2c3ccccc3

| StdInChI_Ref = {{stdinchicite|correct|chemspider}}

| StdInChI = 1S/C15H10O2/c16-14-11-8-4-5-9-12(11)15(17)13(14)10-6-2-1-3-7-10/h1-9,13H

| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}

| StdInChIKey = NFBAXHOPROOJAW-UHFFFAOYSA-N

}}

Phenindione is an anticoagulant which functions as a Vitamin K antagonist.

Phenindione was introduced in the early 1950s. It acts similar to warfarin, but it has been associated with hypersensitivity reactions, so it is rarely used and warfarin is preferred.{{cite journal | vauthors = Naisbitt DJ, Farrell J, Chamberlain PJ, Hopkins JE, Berry NG, Pirmohamed M, Park BK | title = Characterization of the T-cell response in a patient with phenindione hypersensitivity | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 313 | issue = 3 | pages = 1058–65 | date = June 2005 | pmid = 15743920 | doi = 10.1124/jpet.105.083758 | s2cid = 17052792 }}{{cite book | veditors = Sweetman SC |year=2009 | title=Martindale: The Complete Drug Reference |edition=36th |publisher=Pharmaceutical Press| location=London |at="Phenindione", p. 1369}}