phillyrin

{{Chembox

| ImageFile = Phillyrin.png

| ImageSize = 150px

| ImageAlt =

| IUPACName = (7α,7′β,8α,8′α)-3,3′,4′-Trimethoxy-7,9′:7′,9-diepoxylignan-4-yl β-D-glucopyranoside

| SystematicName = (2S,3R,4S,5S,6R)-2-{4-[(1R,3aR,4S,6aR)-4-(3,4-Dimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-2-methoxyphenoxy}-6-(hydroxymethyl)oxane-3,4,5-triol

| OtherNames = Forsythin

|Section1={{Chembox Identifiers

| CASNo = 487-41-2

| CASNo_Ref = {{cascite|correct|CAS}}

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = VE9P4964MG

| ChEBI = 80888

| ChEMBL = 462767

| ChemSpiderID = 91900

| KEGG = C17048

| PubChem = 44584288

| StdInChI=1S/C27H34O11/c1-32-17-6-4-13(8-19(17)33-2)25-15-11-36-26(16(15)12-35-25)14-5-7-18(20(9-14)34-3)37-27-24(31)23(30)22(29)21(10-28)38-27/h4-9,15-16,21-31H,10-12H2,1-3H3/t15-,16-,21+,22+,23-,24+,25+,26-,27+/m0/s1

| StdInChIKey = KFFCKOBAHMGTMW-GBRPDIMTSA-N

| SMILES = COC1=C(C=C(C=C1)[C@@H]2[C@H]3CO[C@H]([C@H]3CO2)C4=CC(=C(C=C4)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O)OC)OC

}}

|Section2={{Chembox Properties

| Formula = C27H34O11

| MolarMass = 534.55 g/mol

| Appearance =

| Density =

| MeltingPt =

| BoilingPt =

| Solubility =

}}

|Section3={{Chembox Hazards

| MainHazards =

| FlashPt =

| AutoignitionPt = }}

}}

Phillyrin is an endophytic fungal isolate with anti-obesity activity. It can be produced by Colletotrichum gloeosporioides, an endophytic fungus isolated from Forsythia suspensa. It can also be prepared directly from Forsythia suspensa.{{cite journal |doi=10.1038/s41401-020-0483-6|title=Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients|year=2020|last1=Su|first1=Hai-xia|last2=Yao|first2=Sheng|last3=Zhao|first3=Wen-Feng|last4=Li|first4=Min-jun|last5=Liu|first5=Jia|last6=Shang|first6=Wei-Juan|last7=Xie|first7=Hang|last8=Ke|first8=Chang-Qiang|last9=Hu|first9=Hang-Chen|last10=Gao|first10=Mei-na|last11=Yu|first11=Kun-Qian|last12=Liu|first12=Hong|last13=Shen|first13=Jing-Shan |last14=Tang|first14=Wei |last15=Zhang|first15=Lei-ke |last16=Xiao|first16=Geng-fu |last17=Ni|first17=Li |last18=Wang|first18=Dao-wen |last19=Zuo|first19=Jian-Ping |last20=Jiang|first20=Hua-Liang |last21=Bai|first21=Fang| last22=Wu|first22=Yan |last23=Ye|first23=Yang |last24=Xu|first24=Ye-Chun|journal=Acta Pharmacologica Sinica|volume=41|issue=9|pages=1167–1177|pmid=32737471|pmc=7393338}}

Notes

{{reflist}}

  • {{cite journal |vauthors=Zhang Q, Wei X, Wang J |title=Phillyrin produced by Colletotrichum gloeosporioides, an endophytic fungus isolated from Forsythia suspensa |journal=Fitoterapia |volume=83 |issue=8 |pages=1500–5 |date=December 2012 |pmid=22960349 |doi=10.1016/j.fitote.2012.08.017}}
  • {{cite journal |vauthors=Zhao Y, Li F, Yang J, An X, Zhou M |title=[Effect of phillyrin on the anti-obesity in nutritive obesity mice] |language=Chinese |journal=Zhong Yao Cai |volume=28 |issue=2 |pages=123–4 |date=February 2005 |pmid=15981888}}
  • Preparative isolation and purification of phillyrin from the medicinal plant Forsythia suspensa by high-speed counter-current chromatography

HB Li, F Chen - Journal of Chromatography A, 2005.

  • Ultrasound-assisted extraction of phillyrin from Forsythia suspensa. EQ Xia, XX Ai, SY Zang, TT Guan, XR Xu, HB Li - Ultrasonics Sonochemistry, 2011

Category:Lignan glucosides

Category:Colletotrichum

Category:Oxygen heterocycles

Category:Methoxy compounds

]