plakophilin

Plakophilin are proteins of the cytoskeleton.{{MeshName|Plakophilins}} They are involved in regulating the adhesive activity of cadherin.{{cite journal | vauthors = Kline CF, Mohler PJ | title = Evolving form to fit function: cardiomyocyte intercalated disc and transverse-tubule membranes | journal = Current Topics in Membranes | volume = 72 | pages = 121–58 | date = 2013-01-01 | pmid = 24210429 | doi = 10.1016/b978-0-12-417027-8.00004-0 | url = http://www.sciencedirect.com/science/article/pii/B9780124170278000040 | access-date = 2020-10-22 | publisher = Academic Press | series = Functional Organization of Vertebrate Plasma Membrane | veditors = Bennett V | url-access = subscription }}

The three types of plakophilin proteins found in humans are PKP1, PKP2, and PKP3; all exhibiting dual localization in the nucleus as well as desmosomes.{{cite book |title=Encyclopedia of Cancer |publisher=Springer, Berlin, Heidelberg |isbn=978-3-642-16483-5 |page=252 |edition=2011 |doi=10.1007/978-3-642-16483-5 |year=2011 |s2cid=27502611 | veditors = Schwab M }}{{cite journal | vauthors = Miller RK, Hong JY, Muñoz WA, McCrea PD | title = Beta-catenin versus the other armadillo catenins: assessing our current view of canonical Wnt signaling | journal = Progress in Molecular Biology and Translational Science | volume = 116 | pages = 387–407 | date = January 2013 | pmid = 23481204 | pmc = 3752792 | doi = 10.1016/b978-0-12-394311-8.00017-0 | publisher = Academic Press | series = The Molecular Biology of Cadherins | veditors = van Roy F }}

Genes include:

• PKP1
• PKP2
• PKP3