proteinase 3

PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown, but, in human neutrophils, proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the target of anti-neutrophil cytoplasmic antibodies (ANCAs) of the c-ANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease granulomatosis with polyangiitis.{{cite journal | vauthors = Hilhorst M, van Paassen P, Tervaert JW | title = Proteinase 3-ANCA Vasculitis versus Myeloperoxidase-ANCA Vasculitis | journal = Journal of the American Society of Nephrology | volume = 26 | issue = 10 | pages = 2314–27 | date = October 2015 | pmid = 25956510 | pmc = 4587702 | doi = 10.1681/ASN.2014090903 }}

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• {{cite journal | vauthors = Martin KR, Witko-Sarsat V | title = Proteinase 3: the odd one out that became an autoantigen | journal = Journal of Leukocyte Biology | volume = 102 | issue = 3 | pages = 689–698 | date = September 2017 | pmid = 28546501 | doi = 10.1189/jlb.3MR0217-069R | doi-access = free }}
• {{cite journal | vauthors = van der Helm-van Mil AH, Huizinga TW, de Vries RR, Toes RE | title = Emerging patterns of risk factor make-up enable subclassification of rheumatoid arthritis | journal = Arthritis and Rheumatism | volume = 56 | issue = 6 | pages = 1728–35 | date = June 2007 | pmid = 17534941 | doi = 10.1002/art.22716 | doi-access = }}
• {{cite journal | vauthors = Kettritz R | title = Neutral serine proteases of neutrophils | journal = Immunological Reviews | volume = 273 | issue = 1 | pages = 232–48 | date = September 2016 | pmid = 27558338 | doi = 10.1111/imr.12441 | s2cid = 29724551 }}
• {{cite journal | vauthors = Zimmer M, Medcalf RL, Fink TM, Mattmann C, Lichter P, Jenne DE | title = Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 89 | issue = 17 | pages = 8215–9 | date = September 1992 | pmid = 1518849 | pmc = 49888 | doi = 10.1073/pnas.89.17.8215 | bibcode = 1992PNAS...89.8215Z | doi-access = free }}
• {{cite journal | vauthors = Cornec D, Cornec-Le Gall E, Fervenza FC, Specks U | title = ANCA-associated vasculitis - clinical utility of using ANCA specificity to classify patients | journal = Nature Reviews. Rheumatology | volume = 12 | issue = 10 | pages = 570–9 | date = October 2016 | pmid = 27464484 | doi = 10.1038/nrrheum.2016.123 | s2cid = 22205737 }}
• {{cite journal | vauthors = Rao NV, Wehner NG, Marshall BC, Gray WR, Gray BH, Hoidal JR | title = Characterization of proteinase-3 (PR-3), a neutrophil serine proteinase. Structural and functional properties | journal = The Journal of Biological Chemistry | volume = 266 | issue = 15 | pages = 9540–8 | date = May 1991 | doi = 10.1016/S0021-9258(18)92854-1 | pmid = 2033050 | doi-access = free }}
• {{cite journal | vauthors = Ohlsson K, Linder C, Rosengren M | title = Monoclonal antibodies specific for neutrophil proteinase 4. Production and use for isolation of the enzyme | journal = Biological Chemistry Hoppe-Seyler | volume = 371 | issue = 7 | pages = 549–55 | date = July 1990 | pmid = 2121162 | doi = 10.1515/bchm3.1990.371.2.549 }}
• {{cite journal | vauthors = Campanelli D, Melchior M, Fu Y, Nakata M, Shuman H, Nathan C, Gabay JE | title = Cloning of cDNA for proteinase 3: a serine protease, antibiotic, and autoantigen from human neutrophils | journal = The Journal of Experimental Medicine | volume = 172 | issue = 6 | pages = 1709–15 | date = December 1990 | pmid = 2258701 | pmc = 2188764 | doi = 10.1084/jem.172.6.1709 }}
• {{cite journal | vauthors = Goldschmeding R, Dolman KM, van den Ende ME, van der Meer-Gerritsen CH, Sonnenberg A, von dem Borne AE | title = The relation of 29 kD C-ANCA antigen to proteinase 3 | journal = APMIS | volume = 98 | issue = S19 | pages = 26–7 | year = 1991 | pmid = 2285532 | doi = 10.1111/j.1600-0463.1990.tb05713.x | s2cid = 37665338 }}
• {{cite journal | vauthors = Wilde CG, Snable JL, Griffith JE, Scott RW | title = Characterization of two azurphil granule proteases with active-site homology to neutrophil elastase | journal = The Journal of Biological Chemistry | volume = 265 | issue = 4 | pages = 2038–41 | date = February 1990 | doi = 10.1016/S0021-9258(19)39936-3 | pmid = 2404977 | doi-access = free }}
• {{cite journal | vauthors = Gabay JE, Scott RW, Campanelli D, Griffith J, Wilde C, Marra MN, Seeger M, Nathan CF | title = Antibiotic proteins of human polymorphonuclear leukocytes | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 86 | issue = 14 | pages = 5610–4 | date = July 1989 | pmid = 2501794 | pmc = 297672 | doi = 10.1073/pnas.86.14.5610 | bibcode = 1989PNAS...86.5610G | doi-access = free }}
• {{cite journal | vauthors = Bories D, Raynal MC, Solomon DH, Darzynkiewicz Z, Cayre YE | title = Down-regulation of a serine protease, myeloblastin, causes growth arrest and differentiation of promyelocytic leukemia cells | journal = Cell | volume = 59 | issue = 6 | pages = 959–68 | date = December 1989 | pmid = 2598267 | doi = 10.1016/0092-8674(89)90752-6 | doi-access = free }}
• {{cite journal | vauthors = Pontremoli S, Melloni E, Michetti M, Sacco O, Sparatore B, Salamino F, Damiani G, Horecker BL | title = Cytolytic effects of neutrophils: role for a membrane-bound neutral proteinase | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 83 | issue = 6 | pages = 1685–9 | date = March 1986 | pmid = 3513185 | pmc = 323148 | doi = 10.1073/pnas.83.6.1685 | bibcode = 1986PNAS...83.1685P | doi-access = free }}
• {{cite journal | vauthors = Sugimori T, Cooley J, Hoidal JR, Remold-O'Donnell E | title = Inhibitory properties of recombinant human monocyte/neutrophil elastase inhibitor | journal = American Journal of Respiratory Cell and Molecular Biology | volume = 13 | issue = 3 | pages = 314–22 | date = September 1995 | pmid = 7654387 | doi = 10.1165/ajrcmb.13.3.7654387 }}
• {{cite journal | vauthors = Brunini F, Page TH, Gallieni M, Pusey CD | title = The role of monocytes in ANCA-associated vasculitides | journal = Autoimmunity Reviews | volume = 15 | issue = 11 | pages = 1046–1053 | date = November 2016 | pmid = 27491570 | doi = 10.1016/j.autrev.2016.07.031 | url = https://air.unimi.it/retrieve/handle/2434/428376/703044/ROLE%20OF%20MONOCYTES%20IN%20AAV%2c%20Brunini%20et%20al%2c%2015.03.2016-1.pdf | hdl = 10044/1/39150 | hdl-access = free }}

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• {{MeshName|Proteinase+3}}

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{{Granule contents}}

{{Serine endopeptidases}}

{{Enzymes}}

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Category:EC 3.4.21

Category:Genes on human chromosome 19