pseudopelletierine

{{short description|Chemical compound}}

{{Chembox

| Verifiedfields = changed

| Watchedfields = changed

| verifiedrevid = 424798005

| ImageFile = pseudopelletierine.png

| ImageSize = 120px

| IUPACName = 9-Methyl-9-azabicyclo[3.3.1]nonan-3-one

| OtherNames = Pseudopunicine; Granatonine; Pseudopelletrierin; Granatan-3-one; Pseudopelletierin; psi-Pelletierine; 9-Methyl-3-granatanone

|Section1={{Chembox Identifiers

| CASNo_Ref = {{cascite|correct|??}}

| CASNo = 552-70-5

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = USN3FV3Z9X

| ChEBI_Ref = {{ebicite|changed|EBI}}

| ChEBI = 8607

| PubChem = 11096

| SMILES = CN1C2CCCC1CC(=O)C2

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|Section2={{Chembox Properties

| C=9 | H=15 | N=1 | O=1

| Appearance = Colorless (yellows on exposure)

| Density =

| MeltingPtC = 54

| BoilingPt = Sublimes at 40 °C (0.3 mmHg)

| Solubility = }}

|Section3={{Chembox Hazards

| MainHazards =

| FlashPt =

| AutoignitionPt = }}

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Pseudopelletierine is the main alkaloid derived from the root-bark of the pomegranate tree (Punica granatum), along with at least three other alkaloids: pelletierine, isopelletierine, and methylpelletierine (C9H17ON), which yield 1.8, 0.52, 0.01, and 0.20 grams per kilogram of raw bark.

It is a homolog of tropinone, and can be synthesized in a manner analogous to the classical Robinson tropinone synthesis, using glutaraldehyde (rather than succinaldehyde), acetonedicarboxylic acid, and methylammonium chloride.{{cite journal|journal=Organic Syntheses|volume= 37|page=73|year=1957|doi=10.15227/orgsyn.037.0073|title=Pseudopelletierine|author=Arthur C. Cope |author2=Hugh L. Dryden Jr. |author3=Charles F. Howell }} It was the starting material for Willstätter's 10-step synthesis of cyclooctatetraene, which was achieved after oxidation and several Hoffman elimination steps.

References