replicative transposition

Replicative transposition is a mechanism of transposition in molecular biology, proposed by James A. Shapiro in 1979,{{citation|last=Shapiro|first=J. A.|authorlink=James A. Shapiro|year=1979|title=Molecular model for the transposition and replication of bacteriophage Mu and other transposable elements|journal=Proceedings of the National Academy of Sciences of the United States of America|volume=76|pages=1933–1937|pmid=287033|url=http://www.pnas.org/content/76/4/1933.full.pdf|doi=10.1073/pnas.76.4.1933|pmc=383507|issue=4|doi-access=free}}. in which the transposable element is duplicated during the reaction, so that the transposing entity is a copy of the original element. In this mechanism, the donor and receptor DNA sequences form a characteristic intermediate "theta" configuration, sometimes called a "Shapiro intermediate".{{citation|title=Lateral DNA transfer: mechanisms and consequences|first=Frederic|last=Bushman|publisher=CSHL Press|year=2002|isbn=978-0-87969-621-4|page=46|url=https://books.google.com/books?id=8oIaOGHURroC&pg=PA46}}. Replicative transposition is characteristic to retrotransposons and occurs from time to time in class II transposons.{{citation|first1=George|last1=Chaconas|first2=Rasika M.|last2=Harshey|year=2002|contribution=Transposition of phage Mu DNA|title=Mobile DNA II|editor1-first=N. L.|editor1-last=Craig|editor2-first=R.|editor2-last=Craigie|editor3-first=M.|editor3-last=Gellert|editor4-first=A. M.|editor4-last=Lambowitz|pages=384–402|publisher=American Society for Microbiology|isbn=9781555812096|url=https://books.google.com/books?id=vRan2aXjiVcC&pg=PA384}}.