rs16891982

{{Short description|SNP in the SLC45A2 gene}}

{{Infobox single nucleotide polymorphism|rsid=rs16891982|name_1=F374L|name_2=c.1122C>G|name_3=|gene=SLC45A2|chromosome=5|region=Exon 5{{cite journal |title=The Interplay between Natural Selection and Susceptibility to Melanoma on Allele 374F of SLC45A2 Gene in a South European Population |journal=PLOS ONE |date=5 August 2014 |volume=9 |issue=8 |pages=e104367 |doi=10.1371/journal.pone.0104367 |issn=1932-6203|doi-access=free |last1=López |first1=Saioa |last2=García |first2=Óscar |last3=Yurrebaso |first3=Iñaki |last4=Flores |first4=Carlos |last5=Acosta-Herrera |first5=Marialbert |last6=Chen |first6=Hua |last7=Gardeazabal |first7=Jesús |last8=Careaga |first8=Jesús María |last9=Boyano |first9=María Dolores |last10=Sánchez |first10=Ana |last11=Ratón-Nieto |first11=Juan Antonio |last12=Sevilla |first12=Arrate |last13=Smith-Zubiaga |first13=Isabel |last14=De Galdeano |first14=Alicia García |last15=Martinez-Cadenas |first15=Conrado |last16=Izagirre |first16=Neskuts |last17=de la Rúa |first17=Concepción |last18=Alonso |first18=Santos |pmid=25093503 |pmc=4122405 |bibcode=2014PLoSO...9j4367L }}|alfred=|alzgene_geneid=|alzgene_polyid=|pdgene_geneid=|pdgene_polyid=|szgene_geneid=|szgene_polyid=}}

In genetics, rs16891982, also known as F374L, is the name for a single nucleotide polymorphism found in the SLC45A2 gene. The SNP consists of two alleles: C (cytosine) and G (guanine).{{Cite web |title=rs16891982 - SNPedia |url=https://www.snpedia.com/index.php/Rs16891982 |access-date=2022-10-01 |website=www.snpedia.com}} It is associated with skin tone and hair/eye color. It is a type of missense mutation.

C allele homozygosity is associated with black hair in people of European descent, although those with this genotype are usually of non-European descent.

C/G allele heterozygosity is associated with black hair in people of European descent

G allele homozygosity is associated with light skin, hair, and eye color (European ancestry),{{Cite journal |last1=Reis |first1=Larissa B. |last2=Bakos |first2=Renato M. |last3=Vianna |first3=Fernanda S. L. |last4=Macedo |first4=Gabriel S. |last5=Jacovas |first5=Vanessa C. |last6=Ribeiro-dos-Santos |first6=André M. |last7=Santos |first7=Sidney |last8=Bakos |first8=Lúcio |last9=Ashton-Prolla |first9=Patricia |date=2020-11-09 |title=Skin pigmentation polymorphisms associated with increased risk of melanoma in a case-control sample from southern Brazil |journal=BMC Cancer |volume=20 |issue=1 |pages=1069 |doi=10.1186/s12885-020-07485-x |pmid=33167923 |pmc=7650158 |issn=1471-2407 |doi-access=free }}{{Cite journal |last1=Siewierska-Górska |first1=A. |last2=Sitek |first2=A. |last3=Żądzińska |first3=E. |last4=Bartosz |first4=G. |last5=Strapagiel |first5=D. |date=2017-03-01 |title=Association of five SNPs with human hair colour in the Polish population |url=https://www.biorxiv.org/content/biorxiv/early/2016/11/12/087429.full.pdf |journal=HOMO |language=en |volume=68 |issue=2 |pages=134–144 |doi=10.1016/j.jchb.2017.02.002 |pmid=28242083 |issn=0018-442X}} those with this genotype also have a slightly higher susceptibility to melanoma.{{Cite web |title=rs16891982 RefSNP Report - dbSNP - NCBI |url=https://www.ncbi.nlm.nih.gov/snp/rs16891982#clinical_significance |access-date=2022-10-01 |website=www.ncbi.nlm.nih.gov}}