rs7341475
{{Infobox single nucleotide polymorphism
| rsid = 7341475
| gene = RELN
| chromosome = 7
| region = Intron 4
| szgene_geneid = 18
| szgene_polyid = 5691
}}
In genetics, rs7341475 is a single nucleotide polymorphism (SNP) in the RELN gene that codes the reelin protein. The gene RELN is mapped to human chromosome 7 (7q22.1). The SNP rs7341475 is located in the fourth intron of RELN. The gene RELN has many more SNPs among its 65 exons and 64 introns, — even in intron 4 there are tens of SNPs.{{Cite web
| url = https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?showRare=on&chooseRs=all&go=Go&locusId=5649
| title = SNP linked to Gene RELN
| publisher = NCBI
| accessdate = 2008-09-09
}}
The SNP has been investigated for a possible link to schizophrenia.
A 2008 genome-wide association study pointed to that a variant of the SNP could elevate the risk for schizophrenia among women.{{Cite journal
| author = Sagiv Shifman, Martina Johannesson, Michal Bronstein, Sam X. Chen, David A. Collier, Nicholas J. Craddock, Kenneth S. Kendler, Tao Li, Michael O'Donovan, F. Anthony O'Neill, Michael J. Owen, Dermot Walsh, Daniel R. Weinberger, Cuie Sun, Jonathan Flint & Ariel Darvasi
| title = Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women
| journal = PLOS Genetics
| volume = 4
| issue = 2
| pages = e28
|date=February 2008
| doi = 10.1371/journal.pgen.0040028
| pmid = 18282107
| pmc = 2242812
| doi-access = free
}} News:
- {{Cite news
|url = http://www.mentalhelp.net/poc/view_doc.php?type=news&id=108022&cn=7
|author = Eric Metcalf
|title = Genetic Variant Found for Women's Schizophrenia
|publisher = MentalHelp.net
|date = 2008-02-19
|accessdate = 2008-09-09
|url-status = dead
|archiveurl = https://web.archive.org/web/20110716061326/http://www.mentalhelp.net/poc/view_doc.php?type=news&id=108022&cn=7
|archivedate = 2011-07-16
}}
- {{Cite news
|url = http://www.psychiatrymatters.md/headlines/fullpage.asp?C=45637397004821296296&xml=/headlines/2008/02_february/week_08/gene_variant_linked_to_female_schizophrenia.xml
|title = Gene variant linked to female schizophrenia
|publisher = PsychiatryMatters.md
|date = 2008-02-25
|accessdate = 2008-09-09
|url-status = dead
|archiveurl = https://archive.today/20130219030028/http://www.psychiatrymatters.md/headlines/fullpage.asp?C=45637397004821296296&xml=/headlines/2008/02_february/week_08/gene_variant_linked_to_female_schizophrenia.xml
|archivedate = 2013-02-19
}}
A 2015 publication reported a meta-analysis across five studies concluding a slight effect of the SNP.{{Cite Q | Q40444084 }}