sarcoglycan

{{Pfam_box

| Symbol = Sarcoglycan_1

| Name = Sarcoglycan beta/gamma/delta

| image =

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| Pfam = PF04790

| InterPro = IPR006875

| SMART =

| PROSITE =

| SCOP =

| TCDB =

| OPM family =

| OPM protein =

| PDB =

| Membranome superfamily = 117

}}

{{Pfam_box

| Symbol = Sarcoglycan_2

| Name = Sarcoglycan alpha/epsilon

| image =

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| Pfam = PF05510

| InterPro = IPR008908

| SMART =

| PROSITE =

| SCOP =

| TCDB =

| OPM family =

| OPM protein =

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}}

The sarcoglycans are a family of transmembrane proteins{{MeshName|Sarcoglycans}} (α, β, γ, δ or ε) involved in the protein complex responsible for connecting the muscle fibre cytoskeleton to the extracellular matrix, preventing damage to the muscle fibre sarcolemma through shearing forces.

The dystrophin glycoprotein complex (DGC) is a membrane-spanning complex that links the interior cytoskeleton to the extracellular matrix in muscle. The sarcoglycan complex is a subcomplex within the DGC and is composed of six muscle-specific, transmembrane proteins (alpha-, beta-, gamma-, delta-, epsilon-,and zeta-sarcoglycan).{{cite web |title=SGCZ sarcoglycan zeta [Homo sapiens (human)] - Gene - NCBI |url=https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=137868 |website=www.ncbi.nlm.nih.gov |access-date=1 December 2021}} The sarcoglycans are asparagine-linked glycosylated proteins with single transmembrane domains.{{cite journal | vauthors = Chockalingam PS, Cholera R, Oak SA, Zheng Y, Jarrett HW, Thomason DB | title = Dystrophin-glycoprotein complex and Ras and Rho GTPase signaling are altered in muscle atrophy | journal = American Journal of Physiology. Cell Physiology | volume = 283 | issue = 2 | pages = C500-11 | date = August 2002 | pmid = 12107060 | doi = 10.1152/ajpcell.00529.2001 }}{{cite journal | vauthors = Wheeler MT, Zarnegar S, McNally EM | title = Zeta-sarcoglycan, a novel component of the sarcoglycan complex, is reduced in muscular dystrophy | journal = Human Molecular Genetics | volume = 11 | issue = 18 | pages = 2147–54 | date = September 2002 | pmid = 12189167 | doi = 10.1093/hmg/11.18.2147 | doi-access = free }}

The disorders caused by the mutations of the sarcoglycans are called sarcoglycanopathies. Mutations in the α, β, γ or δ genes (not ε) encoding these proteins can lead to the associated limb-girdle muscular dystrophy.