sauvagine

{{Short description|Neuropeptide}}

{{Infobox nonhuman protein

| Name = Sauvagine

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| Organism = Phyllomedusa sauvagei

| TaxID = 8395

| Symbol = N/A

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| CAS_number = 74434-59-6

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| UniProt = P01144

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Sauvagine is a neuropeptide from the corticotropin-releasing factor (CRF) family of peptides and is orthologous to the mammalian hormone, urocortin 1, and the teleost fish hormone, urotensin 1.{{cite journal | vauthors = Lovejoy DA, de Lannoy L | s2cid = 24576375 | title = Evolution and phylogeny of the corticotropin-releasing factor (CRF) family of peptides: expansion and specialization in the vertebrates | journal = Journal of Chemical Neuroanatomy | volume = 54 | pages = 50–6 | date = December 2013 | pmid = 24076419 | doi = 10.1016/j.jchemneu.2013.09.006 }} It is 40 amino acids in length,{{cite journal | vauthors = Montecucchi PC, Henschen A | title = Amino acid composition and sequence analysis of sauvagine, a new active peptide from the skin of Phyllomedusa sauvagei | journal = International Journal of Peptide and Protein Research | volume = 18 | issue = 2 | pages = 113–20 | date = August 1981 | pmid = 7309372 | doi = 10.1111/j.1399-3011.1981.tb02047.x}} and has the sequence XGPPISIDLSLELLRKMIEIEKQEKEKQQAANNRLLLDTI-NH2, with a pyrrolidone carboxylic acid modification at the N-terminal and amidation of the C-terminal isoleucine residue. It was originally isolated from the skin of the frog Phyllomedusa sauvagii. Given its relation to other CRF-related peptides, it exerts similar physiological effects as corticotropin-releasing hormone.{{cite journal | vauthors = Falaschi P, D'Urso R, Negri L, Rocco A, Montecucchi PC, Henschen A, Melchiorri P, Erspamer V | title = Potent in vivo and in vitro prolactin inhibiting activity of sauvagine, a frog skin peptide | journal = Endocrinology | volume = 111 | issue = 2 | pages = 693–5 | date = August 1982 | pmid = 7094889 | doi = 10.1210/endo-111-2-693 }}{{cite journal | vauthors = Brown MR, Fisher LA, Spiess J, Rivier J, Rivier C, Vale W | s2cid = 22063430 | title = Comparison of the biologic actions of corticotropin-releasing factor and sauvagine | journal = Regulatory Peptides | volume = 4 | issue = 2 | pages = 107–14 | date = July 1982 | pmid = 6289384 | doi = 10.1016/0167-0115(82)90101-X }}

Sauvagine belongs to the corticotropin-releasing factor (CRF) family that also includes CRF, urocortin l/urotensin l, urocortin II and urocortin III.{{cite journal | vauthors = Fekete EM, Zorrilla EP | title = Physiology, pharmacology, and therapeutic relevance of urocortins in mammals: ancient CRF paralogs | journal = Frontiers in Neuroendocrinology | volume = 28 | issue = 1 | pages = 1–27 | date = April 2007 | pmid = 17083971 | pmc = 2730896 | doi = 10.1016/j.yfrne.2006.09.002 }}