shearinine

image:Shearinine A,D,E,F.png

Shearinines A,D,E,and F, are marine fungal isolates with anticancer activity in vitro. They were isolated from a stain of Penicillium janthinellum Biourge. Their potential anticancer activity has been suggested by their induction of apoptosis in HL-60 cells.{{cite journal | title=Indole alkaloids produced by a marine fungus isolate of Penicillium janthinellum Biourge |vauthors=Smetanina OF, etal | journal=J Nat Prod |date=Jun 2007 | volume=70 | issue=6 | pages=906–9. | doi=10.1021/np060396d | PMID=17555349}} Shearinines D, E and G have also been found to block activity on large-conductance calcium-activated potassium channels.{{cite journal | title=Shearinines D–K, new indole triterpenoids from an endophytic Penicillium sp. (strain HKI0459) with blocking activity on large-conductance calcium-activated potassium channels | author=Xu, Minjuan| journal=Tetrahedron |date=Jan 2007 | volume=63 | issue=2 | pages=435–444 | doi=10.1016/j.tet.2006.10.050|display-authors=etal}}