sodium calcium edetate
{{Short description|Chemical compound}}
{{cs1 config|name-list-style=vanc}}
{{About|the medication|the chemical|Ethylenediaminetetraacetic acid}}
{{use dmy dates|date=July 2020}}
{{Infobox drug
|type =
|IUPAC_name = Calcium disodium 2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate
|image = Sodium calcium edetate.svg
|image_class = skin-invert-image
|synonyms = calcium disodium EDTA, edetate calcium disodium, sodium calcium edetate
|tradename = Calcium disodium versenate, others
|Drugs.com = {{Drugs.com|monograph|edetate-calcium-disodium}}
|pregnancy_AU =
|pregnancy_US = B
|routes_of_administration = IV, IM
|legal_AU =
|legal_CA =
|legal_DE =
|legal_NZ =
| legal_UK =
|legal_US =
|legal_UN =
|legal_status =
|CAS_number = 62-33-9
|ChEBI = 4757
|UNII_Ref = {{fdacite|correct|FDA}}
|UNII = 8U5D034955
|class = chelating agent
|ATC_prefix = V03
|ATC_suffix = AB03
|PubChem = 6093170
|DrugBank = DB00974
|ChemSpiderID = 5883
|SMILES = C(CN(CC(=O)[O-])CC(=O)[O-])N(CC(=O)[O-])CC(=O)[O-].[Na+].[Na+].[Ca+2]
|StdInChI = 1S/C10H16N2O8.Ca.2Na/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;/q;+2;2*+1/p-4
|StdInChIKey = SHWNNYZBHZIQQV-UHFFFAOYSA-J
| C = 10
| H = 12
| Ca = 1
| N = 2
| Na = 2
| O = 8
}}
Sodium calcium edetate (sodium calcium EDTA), also known as edetate calcium disodium among other names, is a medication primarily used to treat lead poisoning, including both short-term and long-term lead poisoning. Sodium calcium edetate came into medical use in the United States in 1953.
Chelation agent
Sodium calcium edetate is in the chelating agent family of medication. It is a salt of edetate with two sodium atoms and one calcium atom.{{cite book | vauthors = Kasture AV |title=Pharmaceutical Chemistry |volume=I |year=2008 |publisher=Pragati Books Pvt. Ltd. |isbn=9788185790121 |page=16.11 |url=https://books.google.com/books?id=ZkoJsQIhDWkC&pg=SA16-PA11 |language=en |url-status=live |archive-url=https://web.archive.org/web/20170116152923/https://books.google.ca/books?id=ZkoJsQIhDWkC&pg=SA16-PA11 |archive-date=2017-01-16}}
It works by binding to a number of heavy metals, which renders them almost inert and allows them to leave the body in the urine.
Edetate disodium (Endrate) is a different formulation which does not have the same effects.
=Medical use=
Sodium calcium edetate's primary use is to treat lead poisoning,
for which it is an alternative to succimer.
It is given by slow injection into a vein or into a muscle.{{cite book |title=WHO Model Formulary 2008 |year=2009 |isbn=9789241547659 |veditors=Stuart MC, Kouimtzi M, Hill SR |author-link=World Health Organization |publisher=World Health Organization |hdl=10665/44053 |hdl-access=free |pages=59, 62, 65}}
For lead encephalopathy sodium calcium edetate is typically used together with dimercaprol.
It may also be used to treat plutonium poisoning.{{cite book | vauthors = Flanagan R, Jones A, Maynard RL |title=Antidotes: Principles and Clinical Applications |year=2003 |publisher=CRC Press |isbn=9780203485071 |page=47 |url=https://books.google.com/books?id=Ux0-AAAAIAAJ&pg=PA47 |language=en |url-status=live |archive-url=https://web.archive.org/web/20170116151507/https://books.google.ca/books?id=Ux0-AAAAIAAJ&pg=PA47 |archive-date=2017-01-16}}
It does not appear to be useful for poisoning by tetra-ethyl lead.
= Side effects =
Common side effects include pain at the site of injection.{{cite web |title=Edetate Calcium Disodium |url=https://www.drugs.com/monograph/edetate-calcium-disodium.html |publisher=The American Society of Health-System Pharmacists |access-date=8 January 2017 |url-status=live |archive-url=https://web.archive.org/web/20170116204307/https://www.drugs.com/monograph/edetate-calcium-disodium.html |archive-date=16 January 2017}} Other side effects may include kidney problems, diarrhea, fever, muscle pains, and low blood pressure. Benefits when needed in pregnancy are likely greater than the risks.
History
Sodium calcium edetate came into medical use in the United States in 1953. It is on the World Health Organization's List of Essential Medicines.{{cite book |title=World Health Organization model list of essential medicines: 21st list 2019 |year=2019 |publisher=World Health Organization |location=Geneva,CH |hdl=10665/325771 |hdl-access=free |id=WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO |last1=Organization |first1=World Health }}
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