spindle cell lipoma
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| caption = Photomicrograph of a spindle cell lipoma.
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| field = Dermatology
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Spindle cell lipoma is an asymptomatic, slow-growing subcutaneous tumor that has a predilection for the posterior back, neck, and shoulders of older men.James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. {{ISBN|0-7216-2921-0}}.{{rp|625}}{{cite book |author=Rapini, Ronald P. |author2=Bolognia, Jean L. |author3=Jorizzo, Joseph L. |title=Dermatology: 2-Volume Set |publisher=Mosby |location=St. Louis |year=2007 |isbn=978-1-4160-2999-1 }}
Signs and symptoms
Spindle cell lipoma is most frequently located in the upper back, shoulder, or posterior neck subcutaneous layer.{{cite journal | last1=Seo | first1=Bommie Florence | last2=Kang | first2=In Sook | last3=Oh | first3=Deuk Young | title=Spindle Cell Lipoma: A Rare, Misunderstood Entity | journal=Archives of Craniofacial Surgery | publisher=Korean Cleft Palate-Craniofacial Association | volume=15 | issue=2 | year=2014 | pages=102–104 | issn=2287-1152 | doi=10.7181/acfs.2014.15.2.102 | pmid=28913200 | pmc=5556811 }} Nonetheless, reports of it occurring in the mediastinum, hypopharynx, larynx, anterior neck, suprasellar region, esophagus, nasal vestibule, tongue, floor of mouth, vallecula, parotid gland, and breast have been made.{{cite journal | last1=D'Antonio | first1=Antonio | last2=Mottola | first2=Giampiero | last3=Caleo | first3=Alessia | last4=Addesso | first4=Maria | last5=Boscaino | first5=Amedeo | title=Spindle Cell Lipoma of the Larynx | journal=Ear, Nose & Throat Journal | publisher=SAGE Publications | volume=92 | issue=6 | year=2013 | issn=0145-5613 | doi=10.1177/014556131309200613 | pages=E9–E11| pmid=23780614 }} The tumor is said to have an average diameter of 4 to 5 cm and is growing slowly. Usually, the tumor is painless and solitary. There have been documented rare instances of numerous lesions, including family occurrences.{{cite journal | last1=Fanburg-Smith | first1=Julie C. | last2=Devaney | first2=Kenneth O. | last3=Miettinen | first3=Markku | last4=Weiss | first4=Sharon W. | title=Multiple Spindle Cell Lipomas | journal=The American Journal of Surgical Pathology | publisher=Ovid Technologies (Wolters Kluwer Health) | volume=22 | issue=1 | year=1998 | issn=0147-5185 | doi=10.1097/00000478-199801000-00005 | pages=40–48| pmid=9422314 }}
Causes
Diagnosis
The diagnosis of spindle cell lipoma is mainly made in conjunction with clinical presentation and after other malignant tumors have been ruled out using cytologic, histologic, and cytogenetic evidence.{{cite journal | last1=Machol | first1=Jacques A. | last2=Cusic | first2=Jenna G. | last3=OʼConnor | first3=Elizabeth A. | last4=Sanger | first4=James R. | last5=Matloub | first5=Hani S. | title=Spindle Cell Lipoma of the Neck | journal=Plastic and Reconstructive Surgery — Global Open | publisher=Ovid Technologies (Wolters Kluwer Health) | volume=3 | issue=11 | year=2015 | issn=2169-7574 | doi=10.1097/gox.0000000000000405 | page=e550| pmid=26893975 | pmc=4727702 }}
According to histology, the lesion is made up of tiny, homogeneous spindle cells and mature adipocytes combined with eosinophilic collagen bundles inside a myxoidstroma. According to immunohistochemical staining, the spindle cells are positive for CD34 but negative for S-100 protein.
See also
References
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Further reading
- {{cite journal | last=Meyer | first=Anders | title=The broadening spectrum of spindle cell lipoma and related tumors: A review | journal=Human Pathology Reports | publisher=Elsevier BV | volume=28 | year=2022 | issn=2772-736X | doi=10.1016/j.hpr.2022.300646 | page=300646 | ref=none| doi-access=free }}
- {{cite journal | last1=Ko | first1=Jennifer S. | last2=Daniels | first2=Brianne | last3=Emanuel | first3=Patrick O. | last4=Elson | first4=Paul | last5=Khachaturov | first5=Vadim | last6=McKenney | first6=Jesse K. | last7=Goldblum | first7=John R. | last8=Billings | first8=Steven D. | title=Spindle Cell Lipomas in Women: A Report of 53 Cases | journal=American Journal of Surgical Pathology | volume=41 | issue=9 | date=2017 | issn=0147-5185 | doi=10.1097/PAS.0000000000000915 | pages=1267–1274 | pmid=28719462 | ref=none}}
External links
- [https://my.clevelandclinic.org/health/diseases/24326-spindle-cell-lipoma Cleveland Clinic]
- [https://dermnetnz.org/topics/spindle-cell-lipoma-pathology DermNet]
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| ICD11 = {{ICD11|XH4E98}}
| ICD10 = {{ICD10|D17.9}}
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{{Soft tissue tumors and sarcomas}}