sumatriptan/naproxen
{{Short description|Pharmaceutical product}}
{{Use dmy dates|date=June 2022}}
{{Infobox drug
| type = combo
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| component1 = Sumatriptan
| class1 = Triptan
| component2 = Naproxen
| class2 = Nonsteroidal anti-inflammatory drug (NSAID)
| tradename = Treximet, Suvexx, others
| Drugs.com = {{drugs.com|monograph|sumatriptan}}
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| DailyMedID = Sumatriptan naproxen
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| routes_of_administration = By mouth
| ATC_prefix = N02
| ATC_suffix = CC51
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| legal_CA = Rx-only
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| legal_US = Rx-only
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| KEGG = D11577
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Sumatriptan/naproxen, sold under the brand name Treximet among others, is a fixed-dose combination medication used to treat migraines. It is taken by mouth. It contains sumatriptan, as the succinate, a serotonin 5-hydroxytryptamine (5-HT) 1b/1d receptor agonist (triptan); and naproxen as the sodium salt, a member of the arylacetic acid group of nonsteroidal anti-inflammatory drugs (NSAIDs).
Medical uses
Sumatriptan/naproxen is indicated for the acute treatment of migraine with or without aura in people twelve years of age and older.
A Cochrane review in 2020 found that the combination of sumatriptan plus naproxen was better than placebo for relieving acute migraine attacks in adults. When the starting headache intensity was mild, 5 in 10 (50%) of people treated with the combination were pain-free at two hours compared with about 2 in 10 (18%) with placebo. Almost 6 in 10 (58%) people with moderate or severe pain who were treated with the combination had pain reduced to mild or none at two hours, compared with 3 in 10 (27%) with placebo. The combination was also better than the same dose of either drug given alone in these people. Results were 5 in 10 (52%) people with sumatriptan alone or about 4 in 10 (44%) with naproxen alone.{{cite journal | vauthors = Law S, Derry S, Moore RA | title = Sumatriptan plus naproxen for the treatment of acute migraine attacks in adults | journal = The Cochrane Database of Systematic Reviews | volume = 4 | issue = 4 | pages = CD008541 | date = April 2016 | pmid = 27096438 | doi = 10.1002/14651858.CD008541.pub3 | pmc = 6485397 }}
Side effects
Some of the listed side effects include dizziness, nausea, sleepiness, dry mouth, pain in neck, throat or jaw, numbness or tingling.{{cite web | url = https://www.drugs.com/treximet.html | title = Treximet | work = Drugs.com }}
References
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External links
- {{cite web | url = https://druginfo.nlm.nih.gov/drugportal/name/sumatriptan%20mixture%20with%20naproxen | publisher = U.S. National Library of Medicine | work = Drug Information Portal | title = Naproxen sodium mixture with sumatriptan succinate }}
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