supralingual administration

{{Short description|A route of administration of a drug by placing it above tongue}}

Supralingual, from the Latin for "above the tongue" (supra + lingual), refers to the pharmacological route of administration by which substances diffuse into the blood through tissues above the tongue.{{cite journal | last1=Panzner | first1=Petr | last2=Petráš | first2=Mark | last3=Sýkora | first3=Tomáš | last4=Lesná | first4=Ivana Králová | last5=Liška | first5=Martin | title=Both sublingual and supralingual routes of administration are effective in long-term allergen-specific immunotherapy | journal=Allergy and Asthma Proceedings | volume=32 | issue=2 | date=2011 | issn=1539-6304 | pmid=21439167 | doi=10.2500/aap.2011.32.3423 | pages=142–150 | url=https://pubmed.ncbi.nlm.nih.gov/21439167 | access-date=2025-06-20}}{{cite journal | last1=Loprete | first1=Luca | last2=Leuratti | first2=Chiara | last3=Frangione | first3=Valeria | last4=Radicioni | first4=Milko | title=Pharmacokinetics of a Novel Sildenafil Orodispersible Film Administered by the Supralingual and the Sublingual Route to Healthy Men | journal=Clinical Drug Investigation | volume=38 | issue=8 | date=2018 | issn=1173-2563 | pmid=29909432 | pmc=6061399 | doi=10.1007/s40261-018-0665-x | doi-access=free | pages=765–772 | url=https://link.springer.com/content/pdf/10.1007/s40261-018-0665-x.pdf | access-date=2025-06-20}}{{cite journal | last1=Bartlett | first1=Jeremy A. | last2=van der Voort Maarschalk | first2=Kees | title=Understanding the oral mucosal absorption and resulting clinical pharmacokinetics of asenapine | journal=AAPS PharmSciTech | volume=13 | issue=4 | date=2012 | issn=1530-9932 | pmid=22936407 | pmc=3513449 | doi=10.1208/s12249-012-9839-7 | doi-access=free | pages=1110–1115 | quote=Oral mucosal (e.g. sub- or supralingual or buccal) administration of drugs is often the route of administration of choice when the drug shows a large first-pass effect after oral delivery.}}It is often the route of administration of choice when one would like the drug to bypass or alleviate the first-pass effect on the drug after oral delivery.