suxibuzone

{{Short description|Analgesic drug used for joint and muscular pain}}

{{Use dmy dates|date=February 2022}}{{Use British English|date=February 2022}}

{{Infobox drug

|Verifiedfields= changed

|Watchedfields = changed

|verifiedrevid = 408916457

|drug_name=

|INN =

|type =

|image = Suxibuzone.png

|image_class = skin-invert-image

|alt = Two-dimensional monochrome diagram showing the structure of the molecule of Suxibuzone, uing the hexagonal style to depict a chemical compound.

|caption = Suxibuzone molecule

|tradename=

|Drugs.com= {{Drugs.com|international|suxibuzone}}

|IUPAC_name= 4-[ [4-butyl-3,5-dioxo-1,2-di(phenyl)pyrazolidin-4-yl]methoxy]-4-oxobutanoic acid

|licence_EU=

|DailyMedID=

|licence_US=

|pregnancy_AU=

|pregnancy_US=

|pregnancy_category=

|legal_AU=

|legal_CA=

|legal_UK=

|legal_US=

|legal_status=

|routes_of_administration=

|bioavailability=

|protein_bound=

|metabolism=

|elimination_half-life=

|excretion=

|CAS_number_Ref= {{Cascite|correct|CAS}}

|CAS_number = 27470-51-5

|ATC_prefix= M02

|ATC_suffix= AA22

|ATC_supplemental= {{ATCvet|M01|AA90}}

|PubChem= 5362

|DrugBank_Ref= {{Drugbankcite|correct|drugbank}}

|DrugBank =

|UNII_Ref= {{Fdacite|correct|FDA}}

|UNII = 86TDZ5WP2B

|KEGG_Ref= {{Keggcite|correct|kegg}}

|KEGG = D01289

|ChEMBL_Ref= {{Ebicite|changed|EBI}}

|ChEMBL = 1414320

|ChemSpiderID_Ref= {{Chemspidercite|changed|chemspider}}

|ChemSpiderID = 5169

|smiles= O=C(O)CCC(=O)OCC2(C(=O)N(c1ccccc1)N(C2=O)c3ccccc3)CCCC

|StdInChI_Ref= {{Stdinchicite|changed|chemspider}}

|StdInChI= 1S/C24H26N2O6/c1-2-3-16-24(17-32-21(29)15-14-20(27)28)22(30)25(18-10-6-4-7-11-18)26(23(24)31)19-12-8-5-9-13-19/h4-13H,2-3,14-17H2,1H3,(H,27,28)

|StdInChIKey_Ref= {{Stdinchicite|changed|chemspider}}

|StdInChIKey = ONWXNHPOAGOMTG-UHFFFAOYSA-N

|C=24|H=26|N=2|O=6

}}

Suxibuzone is an analgesic used for joint and muscular pain. It is a prodrug of the non-steroidal anti-inflammatory drug (NSAID) phenylbutazone,{{Cite journal|vauthors=Yasuda Y, Shindo T, Mitani N, Ishida N, Oono F, Kageyama T|date=1982|title=Comparison of the absorption, excretion, and metabolism of suxibuzone and phenylbutazone in humans|journal=Journal of Pharmaceutical Sciences|volume=71|issue=5|pages=565–72|pmid=7097505|doi=10.1002/jps.2600710521}} and is commonly used in horses.{{Cite journal|vauthors=Sabaté D, Homedes J, Salichs M, Sust M, Monreal L|date=2009|title=Multicentre, controlled, randomised and blinded field study comparing efficacy of suxibuzone and phenylbutazone in lame horses|journal=Equine Veterinary Journal|volume=41|issue=7|pages=700–5|pmid=19927590|doi=10.2746/042516409X464807}}