synthetic ribosome

Synthetic ribosomes are artificial small-molecules that can synthesize peptides in a sequence-specific matter.{{cite journal |title=Synthetic ribosomes |pmc=3609622 | pmid=23324614 |doi=10.4161/bioe.23640 |volume=4 |issue=2 |year=2013 |journal=Bioengineered |pages=63–4 | last1 = Sleator | first1 = RD}}

David Alan Leigh's lab built synthetic ribosome using a chemical structure based on a rotaxane.{{cite journal |title= Sequence-specific peptide synthesis by an artificial small-molecule machine| pmid=23307739 | doi=10.1126/science.1229753 | volume=339 | issue=6116 | journal=Science | pages=189–93 | last1 = Lewandowski | first1 = B | last2 = De Bo | first2 = G | last3 = Ward | first3 = JW | last4 = Papmeyer | first4 = M | last5 = Kuschel | first5 = S | last6 = Aldegunde | first6 = MJ | last7 = Gramlich | first7 = PM | last8 = Heckmann | first8 = D | last9 = Goldup | first9 = SM | last10 = D'Souza | first10 = DM | last11 = Fernandes | first11 = AE | last12 = Leigh | first12 = DA| year=2013 | url=https://www.research.manchester.ac.uk/portal/en/publications/sequencespecific-peptide-synthesis-by-an-artificial-smallmolecule-machine(dc7b8f29-3915-46cd-93a5-1b2419ee7466).html }}

The Cédric Orelle research group created ribosomes with tethered and inseparable subunits (or Ribo-T).{{cite journal |title=Protein synthesis by ribosomes with tethered subunits |doi=10.1038/nature14862 |pmid=26222032 |volume=524 |issue=7563 |journal=Nature |pages=119–124|year=2015 |last1=Orelle |first1=Cédric |last2=Carlson |first2=Erik D. |last3=Szal |first3=Teresa |last4=Florin |first4=Tanja |last5=Jewett |first5=Michael C. |last6=Mankin |first6=Alexander S. |url=https://zenodo.org/record/894862 }}