tAP1

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease.{{cite web | title = Entrez Gene: TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6890}}

• ATP-binding cassette transporter

TAP1 has been shown to interact with:

• HLA-A, and
• Tapasin.{{cite journal | vauthors = Paulsson KM, Kleijmeer MJ, Griffith J, Jevon M, Chen S, Anderson PO, Sjogren HO, Li S, Wang P | title = Association of tapasin and COPI provides a mechanism for the retrograde transport of major histocompatibility complex (MHC) class I molecules from the Golgi complex to the endoplasmic reticulum | journal = J. Biol. Chem. | volume = 277 | issue = 21 | pages = 18266–18271 | date = May 2002 | pmid = 11884415 | doi = 10.1074/jbc.M201388200 | doi-access = free }}{{cite journal | vauthors = Raghuraman G, Lapinski PE, Raghavan M | title = Tapasin interacts with the membrane-spanning domains of both TAP subunits and enhances the structural stability of TAP1 x TAP2 Complexes | journal = J. Biol. Chem. | volume = 277 | issue = 44 | pages = 41786–41794 | date = Nov 2002 | pmid = 12213826 | doi = 10.1074/jbc.M207128200 | doi-access = free }}

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• {{cite journal | vauthors = Townsend A, Trowsdale J | title = The transporters associated with antigen presentation | journal = Semin. Cell Biol. | volume = 4 | issue = 1 | pages = 53–61 | year = 1993 | pmid = 8453065 | doi = 10.1006/scel.1993.1007 }}
• {{cite journal | vauthors = Schölz C, Tampé R | title = The intracellular antigen transport machinery TAP in adaptive immunity and virus escape mechanisms | journal = J. Bioenerg. Biomembr. | volume = 37 | issue = 6 | pages = 509–515 | year = 2006 | pmid = 16691491 | doi = 10.1007/s10863-005-9500-1 | s2cid = 28129678 }}
• {{cite journal | vauthors = Beck S, Kelly A, Radley E, Khurshid F, Alderton RP, Trowsdale J | title = DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing | journal = J. Mol. Biol. | volume = 228 | issue = 2 | pages = 433–441 | year = 1992 | pmid = 1453454 | doi = 10.1016/0022-2836(92)90832-5 }}
• {{cite journal | vauthors = Colonna M, Bresnahan M, Bahram S, Strominger JL, Spies T | title = Allelic variants of the human putative peptide transporter involved in antigen processing | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 89 | issue = 9 | pages = 3932–3936 | year = 1992 | pmid = 1570316 | pmc = 525605 | doi = 10.1073/pnas.89.9.3932 | bibcode = 1992PNAS...89.3932C | doi-access = free }}
• {{cite journal | vauthors = Trowsdale J, Hanson I, Mockridge I, Beck S, Townsend A, Kelly A | title = Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters | journal = Nature | volume = 348 | issue = 6303 | pages = 741–744 | year = 1991 | pmid = 2259383 | doi = 10.1038/348741a0 | s2cid = 4279033 }}
• {{cite journal | vauthors = Spies T, Bresnahan M, Bahram S, Arnold D, Blanck G, Mellins E, Pious D, DeMars R | title = A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway | journal = Nature | volume = 348 | issue = 6303 | pages = 744–747 | year = 1991 | pmid = 2259384 | doi = 10.1038/348744a0 | s2cid = 31875999 }}
• {{cite journal | vauthors = Cerundolo V, Alexander J, Anderson K, Lamb C, Cresswell P, McMichael A, Gotch F, Townsend A | title = Presentation of viral antigen controlled by a gene in the major histocompatibility complex | journal = Nature | volume = 345 | issue = 6274 | pages = 449–452 | year = 1990 | pmid = 2342577 | doi = 10.1038/345449a0 | bibcode = 1990Natur.345..449C | s2cid = 20178053 | doi-access = free }}
• {{cite journal | vauthors = Szafer F, Oksenberg JR, Steinman L | title = New allelic polymorphisms in TAP genes | journal = Immunogenetics | volume = 39 | issue = 5 | pages = 374 | year = 1994 | pmid = 8168860 | doi = 10.1007/BF00189240 | s2cid = 23485390 }}
• {{cite journal | vauthors = Jackson DG, Capra JD | title = TAP1 alleles in insulin-dependent diabetes mellitus: a newly defined centromeric boundary of disease susceptibility | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 90 | issue = 23 | pages = 11079–11083 | year = 1994 | pmid = 8248212 | pmc = 47925 | doi = 10.1073/pnas.90.23.11079 | doi-access = free }}
• {{cite journal | vauthors = Glynne R, Kerr LA, Mockridge I, Beck S, Kelly A, Trowsdale J | title = The major histocompatibility complex-encoded proteasome component LMP7: alternative first exons and post-translational processing | journal = Eur. J. Immunol. | volume = 23 | issue = 4 | pages = 860–866 | year = 1993 | pmid = 8458375 | doi = 10.1002/eji.1830230414 | s2cid = 44733094 }}
• {{cite journal | vauthors = Beck S, Abdulla S, Alderton RP, Glynne RJ, Gut IG, Hosking LK, Jackson A, Kelly A, Newell WR, Sanseau P, Radley E, Thorpe KL, Trowsdale J | title = Evolutionary dynamics of non-coding sequences within the class II region of the human MHC | journal = J. Mol. Biol. | volume = 255 | issue = 1 | pages = 1–13 | year = 1996 | pmid = 8568858 | doi = 10.1006/jmbi.1996.0001 }}
• {{cite journal | vauthors = Chen HL, Gabrilovich D, Tampé R, Girgis KR, Nadaf S, Carbone DP | title = A functionally defective allele of TAP1 results in loss of MHC class I antigen presentation in a human lung cancer | journal = Nat. Genet. | volume = 13 | issue = 2 | pages = 210–213 | year = 1996 | pmid = 8640228 | doi = 10.1038/ng0696-210 | s2cid = 20367760 }}
• {{cite journal | vauthors = Ahn K, Meyer TH, Uebel S, Sempé P, Djaballah H, Yang Y, Peterson PA, Früh K, Tampé R | title = Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47 | journal = EMBO J. | volume = 15 | issue = 13 | pages = 3247–3255 | year = 1996 | pmid = 8670825 | pmc = 451885 | doi = 10.1002/j.1460-2075.1996.tb00689.x}}
• {{cite journal | vauthors = Lewis JW, Neisig A, Neefjes J, Elliott T | title = Point mutations in the alpha 2 domain of HLA-A2.1 define a functionally relevant interaction with TAP | journal = Curr. Biol. | volume = 6 | issue = 7 | pages = 873–883 | year = 1997 | pmid = 8805302 | doi = 10.1016/S0960-9822(02)00611-5 | doi-access = free }}
• {{cite journal | vauthors = Nijenhuis M, Hämmerling GJ | title = Multiple regions of the transporter associated with antigen processing (TAP) contribute to its peptide binding site | journal = J. Immunol. | volume = 157 | issue = 12 | pages = 5467–5477 | year = 1997 | doi = 10.4049/jimmunol.157.12.5467 | pmid = 8955196 | doi-access = free }}
• {{cite journal | vauthors = Gobin SJ, Wilson L, Keijsers V, Van den Elsen PJ | title = Antigen processing and presentation by human trophoblast-derived cell lines | journal = J. Immunol. | volume = 158 | issue = 8 | pages = 3587–3592 | year = 1997 | doi = 10.4049/jimmunol.158.8.3587 | pmid = 9103419 | doi-access = free }}
• {{cite journal | vauthors = Ahn K, Gruhler A, Galocha B, Jones TR, Wiertz EJ, Ploegh HL, Peterson PA, Yang Y, Früh K | title = The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP | journal = Immunity | volume = 6 | issue = 5 | pages = 613–621 | year = 1997 | pmid = 9175839 | doi = 10.1016/S1074-7613(00)80349-0 | doi-access = free }}

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• {{MeshName|TAP1+protein,+human}}

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{{ABC transporters}}

{{NLM content}}

Category:ATP-binding cassette transporters

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