talsupram

{{Short description|Chemical compound}}

{{cs1 config|name-list-style=vanc|display-authors=6}}

{{Drugbox

| IUPAC_name = 3-(3,3-dimethyl-1-phenyl-2-benzothiophen-1-yl)-N-methyl-propan-1-amine

| image = Talsupram.svg

| tradename =

| pregnancy_category =

| legal_status = Uncontrolled

| routes_of_administration = Oral

| bioavailability =

| metabolism =

| elimination_half-life =

| excretion =

| CAS_number = 21489-20-3

| ATC_prefix = none

| ATC_suffix =

| PubChem = 33014

| ChemSpiderID = 30557

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = C6Z73MW6CR

| C=20 | H=25 | N=1 | S=1

}}

Talsupram (Lu 5-005 or Lu 5-003{{cite journal | vauthors = Carlsson A, Fuxe K, Hamberger B, Malmfors T | title = Effect of a new series of bicyclic compounds with potential thymoleptic properties on the reserpine-resistant uptake mechanism of central and peripheral monoamine neurones in vivo and in vitro | journal = British Journal of Pharmacology | volume = 36 | issue = 1 | pages = 18–28 | date = May 1969 | pmid = 5768100 | pmc = 1703539 | doi = 10.1111/j.1476-5381.1969.tb08299.x | doi-access = free | oclc = 6895508396 }}) is a selective norepinephrine reuptake inhibitor (NRI) which was investigated as an antidepressant in the 1960s and 1970s but was never marketed.{{cite journal | vauthors = Pawłowski L, Mazela H | title = Effects of antidepressant drugs, selective noradrenaline-or 5-hydroxytryptamine uptake inhibitors, on apomorphine-induced hypothermia in mice | journal = Psychopharmacology | volume = 88 | issue = 2 | pages = 240–246 | date = June 1986 | pmid = 3006113 | doi = 10.1007/BF00652248 | s2cid = 1732297 | oclc = 5653283278 }}{{cite journal | vauthors = McConathy J, Owens MJ, Kilts CD, Malveaux EJ, Camp VM, Votaw JR, Nemeroff CB, Goodman MM | title = Synthesis and biological evaluation of [11C]talopram and [11C]talsupram: candidate PET ligands for the norepinephrine transporter | journal = Nuclear Medicine and Biology | volume = 31 | issue = 6 | pages = 705–718 | date = August 2004 | pmid = 15246361 | doi = 10.1016/j.nucmedbio.2003.05.001 }}{{cite journal | vauthors = Kelliher P, Kelly JP, Leonard BE, Sánchez C | title = Effects of acute and chronic administration of selective monoamine re-uptake inhibitors in the rat forced swim test | journal = Psychoneuroendocrinology | volume = 28 | issue = 3 | pages = 332–347 | date = April 2003 | pmid = 12573300 | doi = 10.1016/S0306-4530(02)00026-4 | s2cid = 23452713 }} Along with talopram, it is structurally related to the selective serotonin reuptake inhibitor (SSRI) citalopram.{{cite web |url=http://www.healyprozac.com/Book/Introduction.doc |format=DOC |title=The SSRI Issues |website=healyprozac.com |access-date=January 3, 2024}}