tetanic stimulation

{{Short description|High frequency neuron stimulation}}

In neurobiology, a tetanic stimulation consists of a high-frequency sequence of individual stimulations of a neuron.{{Citation needed|date=February 2020|reason=The original source is now broken}} It is associated with potentiation.

High-frequency stimulation causes an increase in release called post-tetanic potentiation (Kandel 2003).{{fact|date=October 2014}} This presynaptic event is caused by calcium influx. Calcium-protein interactions then produce a change in vesicle exocytosis. The result of these changes is to make the postsynaptic cell more likely to fire an action potential.

Tetanic stimulation is used in medicine to detect a non-depolarizing block or a depolarizing block on the neuromuscular junction.{{cite web|last=Livingston|first=Churchill|title=Chapter 36:Tetanic stimulation|url=http://web.squ.edu.om/med-Lib/MED_CD/E_CDs/anesthesia/site/content/v03/030471r00.HTM|publisher=Sultan Qaboos University}} Lower elicitations of tetanic stimulation in aged muscles were shown to be caused by lower levels of anaerobic energy provision in skeletal muscles.