tobramycin/dexamethasone
{{Short description|Pharmaceutical preparation}}
{{Drugbox
| Verifiedfields = changed
| verifiedrevid = 477865033
| type = combo
| component1 = Tobramycin
| class1 = Aminoglycoside antibiotic
| component2 = Dexamethasone
| class2 = Glucocorticoid
| tradename = Tobradex
| Drugs.com = {{drugs.com|ppa|tobramycin-and-dexamethasone}}
| pregnancy_AU =
| pregnancy_US = C
| pregnancy_category =
| routes_of_administration = Eye drops, topical
| ATCvet =
| ATC_prefix = S01
| ATC_suffix = CA01
| legal_AU =
| legal_CA =
| legal_UK =
| legal_US = Rx-only
| legal_status =
| CAS_number_Ref = {{cascite|correct|CAS}}
| CAS_number = 32986-56-4
| CAS_number2_Ref = {{cascite|correct|CAS}}
| CAS_number2 = 50-02-2
| PubChem =
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB00684
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
| ChemSpiderID = 10123949
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = VZ8RRZ51VK
| UNII2_Ref = {{fdacite|correct|FDA}}
| UNII2 = 7S5I7G3JQL
| KEGG_Ref = {{keggcite|changed|kegg}}
| KEGG = D11178
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 28864
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 1747
}}
Tobramycin/dexamethasone, sold under the brand name Tobradex, is a fixed-dose combination medication in the form of eye drops and eye ointment, marketed by Alcon. The active ingredients are tobramycin (an antibiotic) and dexamethasone (a corticosteroid). It is prescribed for the treatment of pink eye in combination with bacterial infections.
Contraindications
It is contraindicated with herpetic and other viral eye infections. Other contraindications include fungal and mycobacterial infections because tobramycin is inactive against those, and the corticoid acts as an immunosuppressive agent, preventing the body's immune system from dealing with the infection. The drops are also contraindicated in patients with corneal lesions.{{cite book|title=Austria-Codex|at=Tobradex-Augentropfen| veditors = Haberfeld H |publisher=Österreichischer Apothekerverlag|location=Vienna|year=2009|edition=2009/2010|isbn=978-3-85200-196-8|language=German}}{{cite web | title=Tobradex- tobramycin and dexamethasone ointment | website=DailyMed | date=24 April 2020 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5538d748-215c-4e3e-b940-ac9baf07d8a1 | access-date=24 September 2020}}{{cite web | title=Tobradex- tobramycin and dexamethasone suspension/ drops | website=DailyMed | date=24 April 2020 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=22b59456-d26a-4f23-b052-3d73e00181eb | access-date=24 September 2020}}{{cite web | title=Tobradex ST- tobramycin / dexamethasone suspension/ drops | website=DailyMed | date=9 September 2019 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d1d48422-8cfc-4e9e-a7f8-56c274d8eb83 | access-date=24 September 2020}}
Side effects
Similarly to other corticosteroid eye drops, side effects include hypersensitivity and, especially after long-term use, secondary eye infections, cataract (clouding of the eye lens) and increased intraocular pressure, leading to glaucoma. Consequently, the drug should not be applied longer than 24 days{{cite journal | vauthors = Faschinger C | date = 3 January 2011 | journal = Österreichische Apothekerzeitung | title = TobraDex | issue = 1/2011 | pages = 13 | language = German }}{{cite book|title=Arzneistoff-Profile| veditors = Dinnendahl V, Fricke U |publisher=Govi Pharmazeutischer Verlag|location=Eschborn, Germany|year=2010|edition=23|volume=2|isbn=978-3-7741-9846-3|language=German}}
Interactions
Anticholinergic eye drops potentiate the risk of increased intraocular pressure. Systemic aminoglycoside antibiotics increase toxicity for ears, nerves and kidney.
Brand names
Tobrason is a brand name in Jordan.{{cite web | title = Jordanian Food and Drug Administration | url = http://www.jfda.jo/}}{{failed verification|date=September 2020}}
References
{{reflist}}
External links
- {{cite web | url = https://druginfo.nlm.nih.gov/drugportal/name/dexamethasone%20mixture%20with%20tobramycin | publisher = U.S. National Library of Medicine | work = Drug Information Portal | title = Dexamethasone mixture with tobramycin }}
{{AminoglycosideAntiBiotics}}
{{Corticosteroids}}
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{{DEFAULTSORT:Tobramycin Dexamethasone}}