toxic heavy metal

The International Union of Pure and Applied Chemistry (IUPAC), which standardizes nomenclature, says the term “heavy metals” is both meaningless and misleading".{{sfn|Duffus|2002}} The IUPAC report focuses on the legal and toxicological implications of describing "heavy metals" as toxins when there is no scientific evidence to support a connection. The density implied by the adjective "heavy" has almost no biological consequences and pure metals are rarely the biologically active substance.{{sfn|Duffus|2002|p=795}}

This characterization has been echoed by numerous reviews.{{sfn|Ali|Khan|2018}} {{sfn|Nieboer|Richardson|1980}}{{sfn|Baldwin|Marshall|1999}} The most widely used toxicology textbook, Casarett and Doull’s toxicology{{sfn|Goyer|Clarkson|1996|p=839}} uses "toxic metal" not "heavy metals".{{sfn|Duffus|2002|p=795}} Nevertheless many scientific and science related articles continue to use "heavy metal" as a term for toxic substances.{{sfn|Pourret|Bollinger|Hursthouse|2021}}

{{Periodic table (micro)|title=|caption=Major toxic metals|mark= As, Be, Cd, Cr,Pb, Hg, Ni}}

Metals with multiple toxic effects include arsenic (As), beryllium (Be), cadmium (Cd), chromium (Cr), lead (Pb), mercury (Hg), and nickel (Ni).{{sfn|Goyer|Clarkson|1996|p=818}}

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{{Periodic table (micro)|title=|caption=Essential but potentially toxic elements|mark= Co, Cu, Fe, Mg, Mn, Mo, Se, Zn}}

Elements that are nutritionally essential for animal or plant life but which are considered toxic metals in high doses or other forms include cobalt (Co), copper (Cu), iron (Fe), magnesium (Mg), manganese (Mn), molybdenum (Mo), selenium (Se), and zinc (Zn).{{sfn|Goyer|Clarkson|1996|p=839}}

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File:Tetraethyllead-3D-balls.png is one of the most significant heavy metal contaminants in recent use.{{sfn|Wright|Welbourn|2002|p=288}}]]

Toxic metals are found naturally in the earth, and become concentrated as a result of human activities, or, in some cases geochemical processes, such as accumulation in peat soils that are then released when drained for agriculture.{{sfn|Qureshi|Richards|McBrideBaveye|2003}} Common sources include fertilisers;{{sfn|Wilson|1997}} aging water supply infrastructure;{{sfn|Harvey| Handley|Taylor|2015}} and microplastics floating in the world's oceans.{{sfn|Howell|Lavers|Paterson|Garrett|2012}}{{sfn|Cole|Lindeque|Halsband|Galloway|2011|p=2589‒2590}} Arsenic is thought to be used in connection with coloring dyes.{{sfn|Finch|Hillyer|Leopold|2015}} Rat poison used in grain and mash stores may be another source of the arsenic.{{sfn|Aggrawal|2014|p=680}}

The geographical extent of sources may be very large. For example, up to one-sixth of China's arable land might be affected by heavy metal contamination.{{sfn|Hillman|Abbot|Yu|Bain|2015|p=3349}}

Lead is the most prevalent heavy metal contaminant.{{sfn|DiMaio|DiMaio|2001|p=527}} As a component of tetraethyl lead, {{chem|(CH|3|CH|2|)|4|Pb}}, it was used extensively in gasoline during the 1930s–1970s.{{sfn|Lovei|1998|p=15}} Lead levels in the aquatic environments of industrialised societies have been estimated to be two to three times those of pre-industrial levels.{{sfn|Perry|Vanderklein|1996|p=336}} Although the use of leaded gasoline was largely phased out in North America by 1996, soils next to roads built before this time retain high lead concentrations. Lead (from lead(II) azide or lead styphnate used in firearms) gradually accumulates at firearms training grounds, contaminating the local environment and exposing range employees to a risk of lead poisoning.{{sfn|Houlton|2014|p=50}}

Toxic metals enter plant, animal and human tissues via air inhalation, diet, and manual handling. Welding, galvanizing, brazing, and soldering exposes workers to fumes that may be inhaled and result in metal fume fever.{{sfn|Kaye|Young|O'Sullivan|2002}} Motor vehicle emissions are a major source of airborne contaminants including arsenic, cadmium, cobalt, nickel, lead, antimony, vanadium, zinc, platinum, palladium and rhodium.{{sfn|Balasubramanian|He|Wang|2009|p=476}} Water sources (groundwater, lakes, streams and rivers) can be polluted by toxic metals leaching from industrial and consumer waste; acid rain can exacerbate this process by releasing toxic metals trapped in soils.{{sfn|Worsztynowicz|Mill|1995|p=361}} Transport through soil can be facilitated by the presence of preferential flow paths (macropores) and dissolved organic compounds.{{sfn|Camobreco|Richards|Steenhuis|Peverly|1996}} Plants are exposed to toxic metals through the uptake of water; animals eat these plants; ingestion of plant- and animal-based foods are the largest sources of toxic metals in humans.{{sfn|Radojevic|Bashkin|1999|p=406}} Absorption through skin contact, for example from contact with soil, or metal containing toys and jewelry,{{sfn|Guney|Zagury|2014}} is another potential source of toxic metal contamination.{{sfn|Qu|Ma|Yang|Lie|2014|p=144}} Toxic metals can bioaccumulate in organisms as they are hard to metabolize.{{sfn|Pezzarossa|Gorini|Petruzelli|2011|p=94}}

Toxic metals "can bind to vital cellular components, such as structural proteins, enzymes, and nucleic acids, and interfere with their functioning".{{sfn|Landis|Sofield|Yu|2000|p=269}} Symptoms and effects can vary according to the metal or metal compound, and the dose involved. Broadly, long-term exposure to toxic heavy metals can have carcinogenic, central and peripheral nervous system, and circulatory effects. For humans, typical presentations associated with exposure to any of the "classical"{{sfn|Nielen|Marvin|2008|p=10}} toxic heavy metals, or chromium (another toxic heavy metal) or arsenic (a metalloid), are shown in the table.{{sfn|Adal|Wiener|2023}}

The toxic effects of arsenic, mercury and lead were known to the ancients but methodical studies of the overall toxicity of heavy metals appear to date from only 1868. In that year, Wanklyn and Chapman speculated on the adverse effects of the heavy metals "arsenic, lead, copper, zinc, iron and manganese" in drinking water. They noted an "absence of investigation" and were reduced to "the necessity of pleading for the collection of data".{{sfn|Wanklyn|Chapman|1868|pp=73–78}}{{sfn|Cameron|1871|p=484}} In 1884, Blake described an apparent connection between toxicity and the atomic weight of an element.{{sfn|Blake| 1884}} The following sections provide historical thumbnails for the "classical" toxic heavy metals (arsenic, mercury and lead) and some more recent examples (chromium and cadmium).

File:Orpiment mineral.jpg, a toxic arsenic mineral used in the tanning industry to remove hair from hides.]]

{{main|Arsenic poisoning}}

Arsenic, as realgar ({{chem|As|4|S|4}}) and orpiment ({{chem|As|2|S|3}}), was known in ancient times. Strabo (64–50 BCE – c. AD 24?), a Greek geographer and historian,{{sfn|Dueck|2000|pp=1–3, 46, 53}} wrote that only slaves were employed in realgar and orpiment mines since they would inevitably die from the toxic effects of the fumes given off from the ores. Arsenic-contaminated beer poisoned over 6,000 people in the Manchester area of England in 1900, and is thought to have killed at least 70 victims.{{sfn|Dyer|2009}} Clare Luce, American ambassador to Italy from 1953 to 1956, suffered from arsenic poisoning. Its source was traced to flaking arsenic-laden paint on the ceiling of her bedroom. She may also have eaten food contaminated by arsenic in flaking ceiling paint in the embassy dining room.{{sfn|Whorton|2011|p=356}} Ground water contaminated by arsenic, as of 2014, "is still poisoning millions of people in Asia".{{sfn|Notman|2014}}

{{see also|Mercury in fish|Mercury poisoning}}

File:Saint Isaac's Cathedral in SPB.jpeg, in Saint Petersburg, Russia. The gold-mercury amalgam used to gild its dome caused numerous casualties among the workers involved.]]

The first emperor of unified China, Qin Shi Huang, it is reported, died of ingesting mercury pills that were intended to give him eternal life.{{sfn|Zhao|Zhu|Sui|2006}} The phrase "mad as a hatter" is likely a reference to mercury poisoning among milliners (so-called "mad hatter disease"), as mercury-based compounds were once used in the manufacture of felt hats in the 18th and 19th century.{{sfn|Waldron|1983}} Historically, gold amalgam (an alloy with mercury) was widely used in gilding, leading to numerous casualties among the workers. It is estimated that during the construction of Saint Isaac's Cathedral alone, 60 workers died from the gilding of the main dome.{{sfn|Emsley|2011|p=326}} Outbreaks of methylmercury poisoning occurred in several places in Japan during the 1950s due to industrial discharges of mercury into rivers and coastal waters. The best-known instances were in Minamata and Niigata. In Minamata alone, more than 600 people died due to what became known as Minamata disease. More than 21,000 people filed claims with the Japanese government, of which almost 3000 became certified as having the disease. In 22 documented cases, pregnant women who consumed contaminated fish showed mild or no symptoms but gave birth to infants with severe developmental disabilities.{{sfn|Davidson|Myers|Weiss|2004|p=1025}} Since the Industrial Revolution, mercury levels have tripled in many near-surface seawaters, especially around Iceland and Antarctica.{{sfn|New Scientist|2014|p=4}}

File:Dutch boy collier white lead.png paint advertisement, 1912.]]

{{Main|Lead poisoning}}

The adverse effects of lead were known to the ancients. In the 2nd century BC the Greek botanist Nicander described the colic and paralysis seen in lead-poisoned people.{{sfn|Pearce|2007}}{{sfn|Needleman|2004}} Dioscorides, a Greek physician who is thought to have lived in the 1st century CE,{{sfn|Rogers|2000|p=41}} wrote that lead "makes the mind give way". Lead was used extensively in Roman aqueducts from about 500 BC to 300 AD.{{sfn|Gilbert|Weiss|2006}} Julius Caesar's engineer, Vitruvius, reported, "water is much more wholesome from earthenware pipes than from lead pipes. For it seems to be made injurious by lead, because white lead is produced by it, and this is said to be harmful to the human body."{{sfn|Prioreschi|1998|p=279}} During the Mongol period in China (1271−1368 AD), lead pollution due to silver smelting in the Yunnan region exceeded contamination levels from modern mining activities by nearly four times.{{sfn|Hillman|Abbot|Yu|Bain|2015|pp=3353–3354}} In the 17th and 18th centuries, people in Devon were afflicted by a condition referred to as Devon colic; this was discovered to be due to the imbibing of lead-contaminated cider. In 2013, the World Health Organization estimated that lead poisoning resulted in 143,000 deaths, and "contribute[d] to 600,000 new cases of children with intellectual disabilities", each year.{{sfn|World Health Organization|2013}} In the U.S. city of Flint, Michigan, lead contamination in drinking water has been an issue since 2014. The source of the contamination has been attributed to "corrosion in the lead and iron pipes that distribute water to city residents".{{sfn|Torrice|2016}} In 2015, the lead concentration of drinking water in north-eastern Tasmania, Australia, reached a level over 50 times the prescribed national drinking water guidelines. The source of the contamination was attributed to "a combination of dilapidated drinking water infrastructure, including lead jointed pipelines, end-of-life polyvinyl chloride pipes and household plumbing".{{sfn|Harvey|Handley|Taylor|2015}}

File:Potassium-chromate-sample.jpg, a carcinogen, is used in the dyeing of fabrics, and as a tanning agent to produce leather.]]

Chromium(III) compounds and chromium metal are not considered a health hazard, while the toxicity and carcinogenic properties of chromium(VI) have been known since at least the late 19th century.{{sfn|Barceloux|1999}} In 1890, Newman described the elevated cancer risk of workers in a chromate dye company.{{sfn|Newman|1890}} Chromate-induced dermatitis was reported in aircraft workers during World War II.{{sfn|Haines|Nieboer|1988|p=504}} In 1963, an outbreak of dermatitis, ranging from erythema to exudative eczema, occurred amongst 60 automobile factory workers in England. The workers had been wet-sanding chromate-based primer paint that had been applied to car bodies.{{sfn|National Research Council|1974|p=68}} In Australia, chromium was released from the Newcastle Orica explosives plant on August 8, 2011. Up to 20 workers at the plant were exposed as were 70 nearby homes in Stockton. The town was only notified three days after the release and the accident sparked a major public controversy, with Orica criticised for playing down the extent and possible risks of the leak, and the state Government attacked for their slow response to the incident.{{sfn|Tovey|2011}}{{sfn|Jones|2011}}{{sfn|O'Brien|Aston|2011}}

File:Cadmium-crystal bar.jpg

{{main|Cadmium poisoning}}

Cadmium exposure is a phenomenon of the early 20th century, and onwards. In Japan in 1910, the Mitsui Mining & Smelting Company began discharging cadmium into the Jinzū River, as a byproduct of mining operations. Residents in the surrounding area subsequently consumed rice grown in cadmium-contaminated irrigation water. They experienced softening of the bones and kidney failure. The origin of these symptoms was not clear; possibilities raised at the time included "a regional or bacterial disease or lead poisoning".{{sfn|Vallero|Letcher|2013|p=240}} In 1955, cadmium was identified as the likely cause and in 1961 the source was directly linked to mining operations in the area.{{sfn|Vallero|Letcher|2013|pp=239–241}} In February 2010, cadmium was found in Walmart exclusive Miley Cyrus jewelry. Wal-Mart continued to sell the jewelry until May, when covert testing organised by Associated Press confirmed the original results.{{sfn|Pritchard|2010}} In June 2010 cadmium was detected in the paint used on promotional drinking glasses for the movie Shrek Forever After, sold by McDonald's Restaurants, triggering a recall of 12 million glasses.{{sfn|Mulvihill|Pritchard|2010}}

{{main|Chelation therapy}}

{{Further|Heavy metal detoxification}}

File:Metal-EDTA.svg.{{sfn|Csuros|1997}}]]

In humans, heavy metal poisoning is generally treated by the administration of chelating agents.{{sfn|Blann|Ahmed|2014|p=465}} These are chemical compounds, such as {{chem|link=Sodium calcium edetate|CaNa|2|EDTA}} (calcium disodium ethylenediaminetetraacetate) that convert heavy metals to chemically inert forms that can be excreted without further interaction with the body. Chelates are not without side effects and can also remove beneficial metals from the body. Vitamin and mineral supplements are sometimes co-administered for this reason{{sfn|American Cancer Society|2008}}{{sfn|National Capital Poison Center|2010}}

Soils contaminated by heavy metals can be remediated by one or more of the following technologies: isolation; immobilization; toxicity reduction; physical separation; or extraction. Isolation involves the use of caps, membranes or below-ground barriers in an attempt to quarantine the contaminated soil. Immobilization aims to alter the properties of the soil so as to hinder the mobility of the heavy contaminants. Toxicity reduction attempts to oxidise or reduce the toxic heavy metal ions, via chemical or biological means into less toxic or mobile forms. Physical separation involves the removal of the contaminated soil and the separation of the metal contaminants by mechanical means. Extraction is an on or off-site process that uses chemicals, high-temperature volatization, or electrolysis to extract contaminants from soils. The process or processes used will vary according to contaminant and the characteristics of the site.{{sfn|Evanko|Dzombak|1997|p=1, 14–40}}

Some elements otherwise regarded as toxic heavy metals are essential, in small quantities, for human health. These elements include vanadium, manganese, iron, cobalt, copper, zinc, selenium, strontium and molybdenum.{{sfn|Bánfalvi|2011|p=12}} A deficiency of these essential metals may increase susceptibility to heavy metal poisoning.{{sfn|Chowdhury|Chandra|1987}}

Selenium is the most toxic of the heavy metals that are essential for mammals.{{sfn|Selinger|1978|p=369}} Selenium is normally excreted and only becomes toxic when the intake exceeds the excretory capacity.{{sfn|Goyer|Clarkson|1996|p=846}}

• Bento Rodrigues dam disaster
• Heavy metal detoxification
• Kingston Fossil Plant coal fly ash slurry spill
• Light metal
• Metal toxicity

{{Reflist|30em}}

{{refbegin |30em}}

• {{cite web |vauthors=Adal A, Wiener SW |title=Heavy Metal Toxicity: Practice Essentials, Pathophysiology, Epidemiology |url=https://emedicine.medscape.com/article/814960-overview |date=10 March 2023 |website=eMedicine}}
• {{cite book |vauthors=Aggrawal A |year=2014 |title=Textbook of Forensic Medicine and Toxicology |publisher=Avichal Publishing Company |location=New Delhi |isbn=978-81-7739-419-1}}
• {{Cite journal |vauthors=Ali H, Khan E |date=2018-01-02 |title=What are heavy metals? Long-standing controversy over the scientific use of the term 'heavy metals' – proposal of a comprehensive definition |url=https://www.tandfonline.com/doi/full/10.1080/02772248.2017.1413652 |journal=Toxicological & Environmental Chemistry |language=en |volume=100 |issue=1 |pages=6–19 |doi=10.1080/02772248.2017.1413652 |bibcode=2018TxEC..100....6A |issn=0277-2248|url-access=subscription }}
• {{cite book |vauthors=Balasubramanian R, He J, Wang LK |chapter=Control, Management, and Treatment of Metal Emissions from Motor Vehicles |veditors=Wang LK, Chen JP, Hung YT, Shammas NK |title=Heavy Metals in the Environment |publisher=CRC Press |year=2009 |isbn=978-1420073164 |pages=475–490 }}
• {{cite journal |vauthors=Baldwin DR, Marshall WJ |title=Heavy metal poisoning and its laboratory investigation |journal=Annals of Clinical Biochemistry: International Journal of Laboratory Medicine |volume=36 |issue=3 |pages=267–300 |year=1999 |doi=10.1177/000456329903600301 |pmid=10376071 |citeseerx=10.1.1.528.7546 |s2cid=26671861 }}
• {{cite book |vauthors=Bánfalvi G |chapter=Heavy Metals, Trace Elements and their Cellular Effects |veditors=Bánfalvi G |title=Cellular Effects of Heavy Metals |url=https://archive.org/details/cellulareffectsh00banf |url-access=limited |publisher=Springer |year=2011 |isbn=9789400704275 |pages=[https://archive.org/details/cellulareffectsh00banf/page/n18 3]–28 }}
• {{cite journal |vauthors=Barceloux DG |title=Chromium |journal=Journal of Toxicology: Clinical Toxicology |volume=37 |issue=2 |pages=173–94 |year=1999 |doi=10.1081/CLT-100102418 |pmid=10382554}}
• {{cite journal |vauthors=Blake J |title=On the Connection Between Physiological Action and Chemical Constitution |journal=The Journal of Physiology |volume=5 |issue=1 |pages=36–44 |year=1884 |pmc=1484879 |pmid=16991361 |doi=10.1113/jphysiol.1884.sp000148}}
• {{cite book |vauthors=Blann A, Ahmed N |title=Blood Science: Principles and Pathology |date=2014 |publisher=John Wiley & Sons |isbn=978-1-118-35142-0 |url=https://books.google.com/books?id=_3l9AgAAQBAJ |language=en}}
• {{cite journal |vauthors=Brathwaite RL, Rabone SD |title=Heavy Metal Sulphide Deposits and Geochemical Surveys for Heavy Metals in New Zealand |journal=Journal of the Royal Society of New Zealand |volume=15 |issue=4 |pages=363–370 |year=1985 |doi=10.1080/03036758.1985.10421713 |doi-access=free |bibcode=1985JRSNZ..15..363B }}
• {{cite journal |vauthors=Cameron CA |title=Half-yearly Report on Public Health |journal=Dublin Quarterly Journal of Medical Science |volume=52 |issue=2 |pages=475–498 |year=1871 |doi=10.1007/BF02944536 }}
• {{cite journal |vauthors=Camobreco VJ, Richards BK, Steenhuis TS, Peverly JH, McBride MB |title=Movement of heavy metals through undisturbed and homogenized soil columns |journal=Soil Science |date=November 1996 |volume=161 |issue=11 |pages=740–750 |doi=10.1097/00010694-199611000-00003|bibcode=1996SoilS.161..740C }}
• {{cite journal |vauthors=Chowdhury BA, Chandra RK |title=Biological and health implications of toxic heavy metal and essential trace element interactions |journal=Progress in Food & Nutrition Science |volume=11 |issue=1 |pages=55–113 |year=1987 |pmid=3303135}}
• {{cite journal |vauthors=Cole M, Lindeque P, Halsband C, Galloway TS |title=Microplastics as contaminants in the marine environment: A review |journal=Marine Pollution Bulletin |volume=62 |issue=12 |year=2011 |pages=2588–2597 |doi=10.1016/j.marpolbul.2011.09.025 |pmid=22001295 |bibcode=2011MarPB..62.2588C |hdl=10871/19649 |hdl-access=free}}
• {{cite book |vauthors=Csuros M |title=Environmental Sampling and Analysis Lab Manual |publisher=Lewis |year=1997 |isbn=978-1566701785 }}
• {{cite journal |vauthors=Davidson PW, Myers GJ, Weiss B |title=Mercury exposure and child development outcomes |journal=Pediatrics |volume=113 |issue=4 Suppl |pages=1023–9 |year=2004 |pmid=15060195 |doi=10.1542/peds.113.S3.1023 |s2cid=6597018 }}
• {{cite news |vauthors=Dewan S |title=Tennessee Ash Flood Larger Than Initial Estimate |newspaper=New York Times |date=26 December 2008 |url=https://www.nytimes.com/2008/12/27/us/27sludge.html}}
• {{cite news |vauthors=Dewan S |title=Metal Levels Found High in Tributary After Spill |newspaper=New York Times |date=1 January 2009 |url=https://www.nytimes.com/2009/01/02/us/02sludge.html}}
• {{cite book |vauthors=DiMaio VJ, DiMaio D |title=Forensic Pathology |publisher=CRC Press |edition=2nd |year=2001 |isbn=978-0849300721 |url=https://archive.org/details/forensicpatholog0000dima }}
• {{cite book |vauthors=Dueck D |title=Strabo of Amasia: A Greek Man of Letters in Augustan Rome |publisher=Routledge |year=2000 |isbn=978-0415216722 }}
• {{cite journal |vauthors=Duffus JH |title=Heavy Metals"—A Meaningless Term? |journal=Pure and Applied Chemistry |volume=74 |issue=5 |pages=793–807 |year=2002 |doi=10.1351/pac200274050793 |s2cid=46602106 |doi-access=free }}
• {{cite journal |vauthors=Dyer P |title=The 1900 Arsenic Poisoning Epidemic |journal=Brewery History |issue=130 |pages=65–85 |year=2009 |url=http://www.breweryhistory.com/journal/archive/130/index.html}}
• {{cite book |vauthors=Emsley J |title=Nature's Building Blocks |publisher=Oxford University Press |year=2011 |isbn=9780199605637 }}
• {{cite journal |vauthors=Evanko CA, Dzombak DA |title=Remediation of Metals-Contaminated Soils and Groundwater |date=1997 |journal=Technology Evaluation Report |id=TE 97-0-1 |citeseerx=10.1.1.401.3768 }}
• {{cite journal |vauthors=Finch LE, Hillyer MM, Leopold MC |year=2015 |title=Quantitative Analysis of Heavy Metals in Children's Toys and Jewelry: A Multi-Instrument Multitechnique Exercise in Analytical Chemistry and Public Health |journal=Journal of Chemical Education |volume=92 |issue=5 |pages=849–854 |doi=10.1021/ed500647w |bibcode=2015JChEd..92..849F}}
• {{cite journal |vauthors=Gilbert SG, Weiss B |title=A Rationale for Lowering the Blood Lead Action Level from 10 to 2 μg/dL |journal=Neurotoxicology |volume=27 |issue=5 |pages=693–701 |year=2006 |doi=10.1016/j.neuro.2006.06.008 |pmid=16889836 |pmc=2212280 |bibcode=2006NeuTx..27..693G }}
• {{Cite book |vauthors=Goyer RA, Clarkson TW |title=Casarett and Doull's toxicology: the basic science of poisons 5 |publisher=McGraw-Hill |year=1996 |chapter=Toxic effects of metals}}
• {{cite journal |vauthors=Guney M, Zagury GJ |title=Bioaccessibility of As, Cd, Cu, Ni, Pb, and Sb in Toys and Low-Cost Jewelry|journal=Environmental Science & Technology|date=4 January 2014|volume=48|issue=2|pages=1238–1246|doi=10.1021/es4036122|pmid=24345102|bibcode=2014EnST...48.1238G|doi-access=free}}
• {{cite book |vauthors=Haines AT, Nieboer E |chapter=Chromium hypersensitivity |veditors=Nriagu JO, Nieboer E |title=Chromium in the Natural and Human Environments |publisher=Wiley |year=1988 |isbn=978-0471856436 |pages=497–532 }}
• {{cite journal |vauthors=Harvey PJ, Handley HK, Taylor MP |title=Identification of the sources of metal (lead) contamination in drinking waters in north-eastern Tasmania using lead isotopic compositions |journal=Environmental Science and Pollution Research |volume=22 |issue=16 |pages=12276–12288 |date=April 2015 |doi=10.1007/s11356-015-4349-2 |pmid=25895456 |bibcode=2015ESPR...2212276H |s2cid=46589151 }}
• {{cite journal |vauthors=Hawkes SJ |title=What is a "Heavy Metal"? |journal=Journal of Chemical Education |volume=74 |issue=11 |page=1374 |year=1997 |doi=10.1021/ed074p1374 |bibcode=1997JChEd..74.1374H }}
• {{cite journal |vauthors=Hillman AL, Abbot MB, Yu JQ, Bain DJ, Chiou-Peng TH |title=Environmental Legacy of Copper Metallurgy and Mongol Silver Smelting Recorded in Yunnan Lake Sediments |journal=Environmental Science & Technology |volume=49 |issue=6 |pages=3349–3357 |year=2015 |doi=10.1021/es504934r |pmid=25685905 |bibcode=2015EnST...49.3349H}}
• {{cite journal |vauthors=Houlton S |title=Boom! |journal=Chemistry World |volume=11 |issue=12 |pages=48–51 |year=2014 |url=http://www.rsc.org/chemistryworld/2014/12/boom-explosives}}
• {{cite web |vauthors=Howell N, Lavers J, Paterson D, Garrett R, Banati R |title=Trace metal distribution in feathers from migratory, pelagic birds |date=2012 |publisher=Australian Nuclear Science and Technology Organisation |url=http://www.ansto.gov.au/AboutANSTO/MediaCentre/News/ACS013097#sthash.wIvPum6r.dpuf |access-date=2014-05-03}}
• {{cite news |vauthors=Jones J |title=Stockton Residents Fume Over Fallout From Orica |newspaper=Newcastle Herald |date=11 August 2011 |url=https://www.newcastleherald.com.au/story/474460/stockton-residents-fume-over-orica-fallout/ |access-date=2014-05-16}}
• {{cite journal |vauthors=Kaye P, Young H, O'Sullivan I |doi=10.1136/emj.19.3.268 |pmid=11971851 |pmc=1725877 |title=Metal fume fever: A case report and review of the literature |journal=Emergency Medicine Journal |volume=19 |issue=3 |pages=268–9 |year=2002}}
• {{cite book |vauthors=Landis WG, Sofield RM, Yu MH |title=Introduction to Environmental Toxicology: Molecular Substructures to Ecological Landscapes |publisher=CRC Press |year=2000 |isbn=9781439804100 |edition=4th}}
• {{cite book |vauthors=Lovei M |title=Phasing Out Lead from Gasoline: Worldwide Experience and Policy Implications |publisher=The World Bank |series=World Bank Technical Paper |volume=397 |year=1998 |isbn=978-0821341575 |url=https://books.google.com/books?id=UQ-vhkW55-sC |issn=0253-7494}}
• {{cite news |vauthors=Mulvihill G, Pritchard J |title=McDonald's Recall: 'Shrek' Glasses Contain Toxic Metal Cadmium |date=4 June 2010 |work=Huffington Post |url=http://www.huffingtonpost.com/2010/06/04/mcdonalds-recall-shrek-glass-cadmium_n_600355.html}}
• {{cite journal |vauthors=Needleman H |title=Lead poisoning |journal=Annual Review of Medicine |volume=55 |pages=209–22 |year=2004 |doi=10.1146/annurev.med.55.091902.103653 |pmid=14746518 }}
• {{cite journal |vauthors=Newman D |title=A Case of Adeno-carcinoma of the Left Inferior Turbinated Body, and Perforation of the Nasal Septum, in the Person of a Worker in Chrome Pigments |journal=Glasgow Medical Journal |volume=33 |pages=469–470 |year=1890 }}
• {{Cite journal |vauthors=Nieboer E, Richardson DH |date=1980-01-01 |title=The replacement of the nondescript term 'heavy metals' by a biologically and chemically significant classification of metal ions |url=https://linkinghub.elsevier.com/retrieve/pii/0143148X80900178 |journal=Environmental Pollution Series B, Chemical and Physical |volume=1 |issue=1 |pages=3–26 |doi=10.1016/0143-148X(80)90017-8 |issn=0143-148X|url-access=subscription }}
• {{cite book |vauthors=Nielen MW, Marvin HJ |chapter=Challenges in Chemical Food Contaminants and Residue Analysis |veditors=Picó Y |title=Food Contaminants and Residue Analysis |publisher=Elsevier |year=2008 |isbn=978-0080931920 |pages=17–28 }}
• {{cite journal |vauthors=Notman N |title=Digging Deep for Safer Water |journal=Chemistry World |volume=11 |issue=4 |pages=54–57 |year=2014 |url=http://www.rsc.org/chemistryworld/2014/03/arsenic-asia-groundwater}}
• {{cite news |vauthors=O'Brien N, Aston H |title=The untold story of Orica's chemical leaks |newspaper=Sydney Morning Herald |date=13 November 2011 |url=http://www.smh.com.au/environment/the-untold-story-of-oricas-chemical-leaks-20111112-1ncup.html}}
• {{cite journal |vauthors=Pearce JM |title=Burton's Line in Lead Poisoning |journal=European Neurology |volume=57 |issue=2 |pages=118–9 |year=2007 |doi=10.1159/000098100 |pmid=17179719 |s2cid=41427430 |doi-access=free }}
• {{cite book |vauthors=Perry J, Vanderklein EL |title=Water Quality: Management of a Natural Resource |publisher=Blackwell Science |year=1996 |isbn=978-0865424692 }}
• {{cite book |vauthors=Pezzarossa B, Gorini F, Petruzelli G |chapter=Heavy Metal and Selenium Distribution and Bioavailability in Contaminated Sites: A Tool for Phytoremediation |veditors=Selim HM |title=Dynamics and Bioavailabiliy of Heavy Metals in the Rootzone |publisher=CRC Press |year=2011 |isbn=9781439826225 |pages=93–128 }}
• {{cite news |vauthors=Poovey B |title=Trial Starts on Damage Lawsuits in TVA Ash Spill |newspaper=Bloomberg Businessweek |date=15 September 2001 }}
• {{Cite journal |vauthors=Pourret O, Bollinger JC, Hursthouse A |date=June 2021 |title=Heavy metal: a misused term? |url=https://link.springer.com/10.1007/s11631-021-00468-0 |journal=Acta Geochimica |language=en |volume=40 |issue=3 |pages=466–471 |doi=10.1007/s11631-021-00468-0 |bibcode=2021AcGch..40..466P |issn=2096-0956}}
• {{cite book |vauthors=Prioreschi P |title=Roman Medicine |series=A History of Medicine |volume=III |publisher=Horatius Press |year=1998 |isbn=978-1888456035 }}
• {{cite news |vauthors=Pritchard J |title=Wal-Mart Pulls Miley Cyrus Jewelry After Cadmium Tests |newspaper=USA Today |date=19 May 2010 |url=https://www.usatoday.com/life/people/2010-05-19-miley-cyrus_N.htm?csp=34}}
• {{cite book |vauthors=Qu C, Ma Z, Yang J, Lie Y, Bi J, Huang L |chapter=Human Exposure Pathways of Heavy Metal in a Lead-Zinc Mining Area |veditors=Asrari E |title=Heavy Metal Contamination of Water and Soil: Analysis, assessment, and remediation strategies |publisher=Apple Academic Press |year=2014 |isbn=9781771880046 |pages=129–156 }}
• {{cite journal |vauthors=Qureshi S, Richards BK, McBride MB, Baveye P, Steenhuis TS |title=Temperature and Microbial Activity Effects on Trace Element Leaching from Metalliferous Peats |journal=Journal of Environmental Quality |date=2003 |volume=32 |issue=6 |pages=2067–75 |doi=10.2134/jeq2003.2067|pmid=14674528 |bibcode=2003JEnvQ..32.2067Q }}
• {{cite book |vauthors=Radojevic M, Bashkin VN |title=Practical Environmental Analysis |publisher=Royal Society of Chemistry |year=1999 |isbn=978-0854045945 }}
• {{cite book |vauthors=Rand GM, Wells PG, McCarty LS |chapter=Introduction to aquatic toxicology |veditors=Rand GM |title=Fundamentals Of Aquatic Toxicology: Effects, Environmental Fate And Risk Assessment |publisher=Taylor & Francis |edition=2nd |year=1995 |isbn=978-1560320906 |pages=3–70 }}
• {{cite book |vauthors=Rogers MJ |chapter=Text and Illustrations. Dioscorides and the Illuminated Herbal in the Arab Tradition |veditors=Contadini A |title=Arab Painting: Text and Image in Illustrated Arabic Manuscripts |publisher=Koninklijke Brill NV |location=Leiden |year=2000 |isbn=9789004186309 |pages=41–48 [41] }}
• {{cite book |vauthors=Selinger B |date=1978 |title=Chemistry in the Market Place |edition=2nd |publisher=Australian National University Press |location=Canberra |isbn=978-0-7081-0728-7}}
• {{cite book |vauthors=Sengupta AK |chapter=Principles of Heavy Metals Separation |veditors=Sengupta AK |title=Environmental Separation of Heavy Metals: Engineering Processes |publisher=Lewis |year=2002 |isbn=978-1566768849 }}
• {{cite book |vauthors=Srivastava S, Goyal P |title=Novel Biomaterials: Decontamination of Toxic Metals from Wastewater |publisher=Springer-Verlag |year=2010 |isbn=978-3-642-11329-1 }}
• {{cite journal |vauthors=Torrice M |title=How Lead Ended Up In Flint's Tap Water |journal=Chemical & Engineering News |volume=94 |issue=7 |pages=26–29 |url=http://cen.acs.org/articles/94/i7/Lead-Ended-Flints-Tap-Water.html|year=2016 |doi=10.1021/cen-09407-scitech1|url-access=subscription }}
• {{cite news |vauthors=Tovey J |title=Patches of Carcinogen Seen After Orica Leak |newspaper=The Sydney Morning Herald |date=17 December 2011 |url=http://www.smh.com.au/environment/patches-of-carcinogen-seen-after-orica-leak-20111216-1oyo5.html }}
• {{cite book |vauthors=Vallero DA, Letcher TM |title=Unravelling environmental disasters |publisher=Elsevier |year=2013 |isbn=9780123970268 }}
• {{cite journal |vauthors=Waldron HA |title=Did the Mad Hatter have Mercury Poisoning? |journal=British Medical Journal |volume=287 |issue=6409 |pages=1961 |year=1983 |doi=10.1136/bmj.287.6409.1961 |pmid=6418283 |pmc=1550196}}
• {{cite book |vauthors=Wanklyn JA, Chapman ET |title=Water-analysis: A Practical Treatise on the Examination of Potable Water |url=https://archive.org/details/wateranalysisap05chapgoog |year=1868 |publisher=Trüber & Company}}
• {{cite book |vauthors=Whorton JG |title=The Arsenic Century |publisher=Oxford University Press |year=2011 |isbn=9780199605996 }}
• {{cite web |vauthors=Wilson D |date=July 3, 1997| url=https://archive.seattletimes.com/archive/?date=19970703&slug=2547772 | title=Fear In The Fields -- How Hazardous Wastes Become Fertilizer -- Spreading Heavy Metals On Farmland Is Perfectly Legal, But Little Research Has Been Done To Find Out Whether It's Safe|work=Seattle Times}}
• {{cite book |vauthors=Worsztynowicz A, Mill W |chapter=Potential Ecological Risk due to Acidification of Heavy Industrialized Areas — The Upper Silesia Case |veditors=Erisman JW, Hey GJ |title=Acid Rain Research: Do We Have Enough Answers? |publisher=Elsevier |year=1995 |isbn=978-0444820389 |pages=[https://archive.org/details/acidrainresearch0000unse/page/353 353–66] |chapter-url=https://archive.org/details/acidrainresearch0000unse |url=https://archive.org/details/acidrainresearch0000unse/page/353 }}
• {{cite book |vauthors=Wright DA, Welbourn P |title=Environmental Toxicology |publisher=Cambridge University Press |year=2002 |isbn=978-0521581516 }}
• {{cite journal |vauthors=Zhao HL, Zhu X, Sui Y |title=The short-lived Chinese emperors |journal=Journal of the American Geriatrics Society |volume=54 |issue=8 |pages=1295–6 |year=2006 |doi=10.1111/j.1532-5415.2006.00821.x |pmid=16914004 |s2cid=31630319 |doi-access=free }}
• {{cite web |title=Chelation Therapy |date=2008 |publisher=American Cancer Society |url=http://www.cancer.org/treatment/treatmentsandsideeffects/complementaryandalternativemedicine/pharmacologicalandbiologicaltreatment/chelation-therapy |access-date=2014-04-28 |ref={{sfnref|American Cancer Society|2008}}}}
• {{cite web |title=Chelation: Therapy or "Therapy"? |date=2010 |publisher=National Capital Poison Center |url=http://www.poison.org/current/chelationtherapy.htm |ref={{sfnref|National Capital Poison Center|2010}}}}
• {{cite web |url=http://rarediseases.org/rare-diseases/heavy-metal-poisoning/ |title=Heavy Metal Poisoning |vauthors= |date=2015 |publisher=National Organization for Rare Disorders |access-date=11 February 2016 |ref={{sfnref|National Organization for Rare Disorders |2015}}}}
• {{cite book |vauthors=((National Research Council (US))), ((Committee on Biologic Effects of Atmospheric Pollutants)) |title=Chromium |url=https://books.google.com/books?id=xkcrAAAAYAAJ |year=1974 |publisher=National Academies |id=NAP:13852 |isbn=9780309022170 |ref={{sfnref|National Research Council|1974}}}}
• {{cite journal |title=Missing mercury pollution is enough for mass poisoning |journal=New Scientist |volume=223 |issue=2981 |year=2014 |url=https://www.newscientist.com/article/mg22329811.800-missing-mercury-pollution-is-enough-for-mass-poisoning.html#.U_A1HmPNmKw |ref={{sfnref|New Scientist |2014}}}}
• {{cite book |title=The United States Pharmacopeia |publisher=The United States Pharmacopeial Convention |edition=21st |year=1985 |isbn=978-0-913595-04-6 }}
• {{cite web |title=Stop Lead Poisoning in Children |date=2013 |publisher=World Health Organization |url=https://www.who.int/mediacentre/news/notes/2013/lead-20131018/en/ |archive-url=https://web.archive.org/web/20140403065947/http://www.who.int/mediacentre/news/notes/2013/lead-20131018/en/ |url-status=dead |archive-date=April 3, 2014 |ref={{sfnref|World Health Organization|2013}}}}
• {{cite web |title=Ten Chemicals of Major Public Health Concern |date=2015 |publisher=World Health Organization |url=https://www.who.int/ipcs/assessment/public_health/chemicals_phc/en/ |archive-url=https://web.archive.org/web/20110507034021/http://www.who.int/ipcs/assessment/public_health/chemicals_phc/en/ |url-status=dead |archive-date=May 7, 2011 |ref={{sfnref|World Health Organization|2015}}}}
• {{Cite web|date=1 June 2020|title=10 chemicals of public health concern|url=https://www.who.int/news-room/photo-story/photo-story-detail/10-chemicals-of-public-health-concern|access-date=2021-10-09|publisher=World Health Organization|language=en|ref={{sfnref|World Health Organization|2020}}}}

{{refend}}

{{Wastewater}}

{{Poisoning and toxicity}}

{{Elements in biology}}

{{Authority control}}

Category:Sets of chemical elements

Category:Toxicology