tregalizumab

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| Verifiedfields = changed

| verifiedrevid = 470612638

| type = mab

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| mab_type = mab

| source = zu

| target = CD4

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| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}

| ChemSpiderID = none

| CAS_number_Ref = {{cascite|changed|??}}

| CAS_number = 1207446-68-1

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = 43D26MK176

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| synonyms = BT-061

}}

Tregalizumab is an immunomodulator.{{cite journal|author=World Health Organization|year=2010|title=International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 104|url=https://www.who.int/medicines/publications/druginformation/innlists/Final_PL104.pdf|journal=WHO Drug Information|volume=24|issue=4}} It is also known as BT-061. Tregalizumab binds to domain 2 of CD4,{{cite journal | vauthors = Helling B, König M, Dälken B, Engling A, Krömer W, Heim K, Wallmeier H, Haas J, Wildemann B, Fritz B, Jonuleit H, Kubach J, Dingermann T, Radeke HH, Osterroth F, Uherek C, Czeloth N, Schüttrumpf J | display-authors = 6 | title = A specific CD4 epitope bound by tregalizumab mediates activation of regulatory T cells by a unique signaling pathway | journal = Immunology and Cell Biology | volume = 93 | issue = 4 | pages = 396–405 | date = April 2015 | pmid = 25512343 | pmc = 4407014 | doi = 10.1038/icb.2014.102 }} and activates Regulatory T cells (Tregs).{{cite journal | vauthors = König M, Rharbaoui F, Aigner S, Dälken B, Schüttrumpf J | title = Tregalizumab - A Monoclonal Antibody to Target Regulatory T Cells | journal = Frontiers in Immunology | volume = 7 | pages = 11 | date = Jan 2016 | pmid = 26834751 | pmc = 4724712 | doi = 10.3389/fimmu.2016.00011 | doi-access = free }}