trichuriasis

Light infestations (<100 worms) frequently have no symptoms. Heavier infestations, especially in small children, can present gastrointestinal problems including abdominal pain and distension, bloody or mucus-filled diarrhea, and tenesmus (feeling of incomplete defecation, generally accompanied by involuntary straining). Mechanical damage to the intestinal mucosa, and toxic, or inflammatory damage to the host's intestines may occur. While appendicitis may be brought on by damage and edema of the adjacent tissue, if there are large numbers of worms or larvae present, it has been suggested that the embedding of the worms into the ileocecal region may also make the host susceptible to bacterial infection. A severe infection with high numbers of embedded worms in the rectum leads to edema, which can cause rectal prolapse, although this is typically only seen in small children. The prolapsed, inflamed, and edematous rectal tissue may even show visible worms.{{citation needed|date=July 2020}}

Physical growth delay, weight loss, nutritional deficiencies, and anemia (due to long-standing blood loss) are also characteristic of infection, and these symptoms are more prevalent and severe in children. It can cause eosinophilia but it is not common.{{cite journal

| last1 = Abdullah

| first1 = Nasturah

| last2 = Baharudin

| first2 = Noorhida

| last3 = Mohd Rustam

| first3 = Farah Roslinda

| last4 = Khalid

| first4 = Zalizah

| title = Significant Leukocytosis with Hypereosinophilia Secondary to Trichuris trichiura in Adult: A Case Report

| journal = Clinics and Practice

| volume = 11

| issue = 4

| pages = 785–790

| date = 2021-11-26

| language = English

| doi = 10.3390/clinpract11040094

| pmid = 34842643

| pmc = 8628709

| doi-access = free

}}

Coinfection of T. trichiura with other parasites is common and with larger worm burdens can cause both exacerbations of dangerous trichuriasis symptoms such as massive gastrointestinal bleeding (shown to be especially dramatic with coinfection with Salmonella typhi) and exacerbation of symptoms and pathogenesis of the other parasitic infection (as is typical with coinfection with Schistosoma mansoni, in which higher worm burden and liver egg burden is common). Parasitic coinfection with HIV/AIDS, tuberculosis, and malaria is also common, especially in sub-Saharan Africa, and helminth coinfection adversely affects the natural history and progression of HIV/AIDS, tuberculosis, and malaria and can increase clinical malaria severity. In a study performed in Senegal, infections of soil-transmitted helminths like T. trichiura (as well as schistosome infections independently) showed enhanced risk and increased the incidence of malaria.{{cite journal

| last1 = Le Hesran

| first1 = J.Y.

| last2 = Akiana

| first2 = J.

| last3 = Ndiaye

| first3 = el H.M.

| last4 = Dia

| first4 = M.

| last5 = Senghor

| first5 = P.

| last6 = Konate

| first6 = L.

| title = Severe malaria attach is associated with high prevalence of Ascaris lumbricoides infection among children in rural Senegal.

| journal = Transactions of the Royal Society of Tropical Medicine and Hygiene

| volume = 98

| issue = 7

| pages = 397–9

| date = Jul 2004

| language = English

| doi = 10.1016/j.trstmh.2003.10.009

| pmid = 15138075

}}

Heavy infestations may have bloody diarrhea. Long-standing blood loss may lead to iron-deficiency anemia.{{cite journal|author1=Gyorkos TW|author2=Gilbert NL|author3=Larocque R |author4=Casapía M|journal=Trop Med Int Health|year=2011|volume=16|issue=4|pages=531–7|title=Trichuris and hookworm infections associated with anaemia during pregnancy|doi=10.1111/j.1365-3156.2011.02727.x|pmid=21281406|s2cid=205391965|doi-access=}} Vitamin A deficiency may also result due to infection.{{cite web |url=http://www.medterms.com/script/main/art.asp?articlekey=12961 |title=Trichuris trichiura definition - Medical Dictionary definitions of popular medical terms easily defined on MedTerms |publisher=Medterms.com |date=2000-04-15 |access-date=2009-05-19 |url-status=live |archive-url=https://web.archive.org/web/20110606011050/http://www.medterms.com/script/main/art.asp?articlekey=12961 |archive-date=2011-06-06 }}

Trichuriasis is caused by a parasitic worm also known as a helminth called Trichuris trichiura. It belongs to the genus Trichuris, formerly known as Trichocephalus, meaning hair head, which would be a more accurate name; however the generic name is now Trichuris, which means hair tail (implying that the posterior end of the worm is the attenuated section). Infections by parasitic worms are known as helminthiasis.{{citation needed|date=May 2021}}

Humans are the main, but not the only reservoir for T. trichiura. Recent research verified by the application of molecular techniques (PCR) that dogs are a reservoir for T. trichiura, as well as T. vulpis.{{cite journal|last=Areekul|first=Pannatat|author2=Jongwutiwes |title=Trichuris vulpis and T. trichiura infections among schoolchildren of a rural community in northwestern Thailand: the possible role of dogs in disease transmission|journal=Asian Biomedicine|date=February 2010|volume=4|issue=1|pages=49–60|doi=10.2478/abm-2010-0006|doi-access=free}}

Non-biting cyclorrhaphan flies (Musca domestica, M. sorbens, Chrysomya rufifacies, C. bezziana, Lucina cuprina, Calliphora vicina and Wohlfarthia magnifica) have been found to carry Trichuris trichiura. A study in two localized areas in Ethiopia found cockroaches were carriers for several human intestinal parasites, including T. trichiura.{{citation needed|date=May 2021}}

Humans can become infected with the parasite due to ingestion of infective eggs by mouth contact with hands or food contaminated with egg-carrying soil. However, there have also been rare reported cases of transmission of T. trichiura by sexual contact. Some major outbreaks have been traced to contaminated vegetables (due to presumed soil contamination).{{citation needed|date=May 2021}}

Unembryonated eggs (unsegmented) are passed in the feces of a previous host to the soil. In the soil, these eggs develop into a 2-cell stage (segmented egg) and then into an advanced cleavage stage. Once at this stage, the eggs embryonate and then become infective, a process that occurs in about 15 to 30 days). Next, the infective eggs are ingested by way of soil-contaminated hands or food and hatch inside the small intestine, releasing larvae into the gastrointestinal tract. These larvae burrow into a villus and develop into adults (over 2–3 days). They then migrate into the cecum and ascending colon where they thread their anterior portion (whip-like end) into the tissue mucosa and reside permanently for their year-long lifespan. About 60 to 70 days after infection, female adults begin to release unfertilized eggs (oviposit) into the cecum at a rate of 3,000 to 20,000 eggs per day, linking the life cycle to the start.{{citation needed|date=May 2021}}

• The exact incubation period of T. trichiura is unknown, however, immature eggs in soil under favorable conditions take about three weeks to mature: 15–30 days, 10 days minimum to mature before ideal ingestion by the human host. Favorable conditions for maturation of eggs are warm to temperate climates with adequate humidity or precipitation, as ova are resistant to cold, but not resistant to drying.{{citation needed|date=March 2023}}
• Once ingested, the larva will remain dug into a villus in the small intestine for about 2–3 days until it is fully developed for migration to the ileocecal section of the gastrointestinal tract.{{citation needed|date=March 2023}}
• The average total life span of T. trichiura is one year, although there have been longer cases reported, lasting as long as five years (Note: inadequate treatment and re-infection are likely to play a role in this).{{citation needed|date=March 2023}}

File:Trichuris trichiura egg (01).tif

Adult worms are usually {{convert|3|–|5|cm|in}} long, with females being larger than males as is typical of nematodes. The thin, clear majority of the body (the anterior, whip-like end) is the esophagus, and it is the end that the worm threads into the mucosa of the colon. The widened, pinkish-gray region of the body is the posterior, and it is the end that contains the parasite's intestines and reproductive organs.

T. trichiura eggs are prolate spheroids, the shape of the balls used in Rugby and Gridiron football. They are about {{cvt|50|-|54|μm|lk=in}} long and have polar plugs (also known as refractile prominences) at each end.{{citation needed|date=May 2021}}

A stool ova and parasites exam reveals the presence of typical whipworm eggs. Typically, the Kato-Katz thick-smear technique is used for identification of the Trichuris trichiura eggs in the stool sample. Trichuria eggs often appear larger and more swollen on Kato-Katz preparation compared to when using other techniques.{{cite book|url=https://www.who.int/intestinal_worms/resources/9789241515344/en/|archive-url=https://web.archive.org/web/20191018145433/https://www.who.int/intestinal_worms/resources/9789241515344/en/|archive-date=October 18, 2019|author=Dr A. Montresor|title=Bench Aids for the diagnosis of intestinal parasites, Second edition|date=2 September 2019|publisher=World Health Organization |isbn=978-92-4-151534-4}}

Although colonoscopy is not typically used for diagnosis, as the adult worms can be overlooked, especially with an imperfect colon, there have been reported cases in which colonoscopy has revealed adult worms. Colonoscopy can directly diagnose trichuriasis by identification of the threadlike form of worms with an attenuated, whip-like end. Colonoscopy is a useful diagnostic tool, especially in patients infected with only a few male worms and with no eggs presenting in the stool sample.{{Cite journal |last1=Ok |first1=Kyung-Sun |last2=Kim |first2=You-Sun |last3=Song |first3=Jung-Hoon |last4=Lee |first4=Jin-Ho |last5=Ryu |first5=Soo-Hyung |last6=Lee |first6=Jung-Hwan |last7=Moon |first7=Jeong-Seop |last8=Whang |first8=Dong-Hee |last9=Lee |first9=Hye-Kyung |date=September 2009 |title=Trichuris trichiura Infection Diagnosed by Colonoscopy: Case Reports and Review of Literature |journal=The Korean Journal of Parasitology |volume=47 |issue=3 |pages=275–280 |doi=10.3347/kjp.2009.47.3.275 |issn=0023-4001 |pmc=2735694 |pmid=19724702}}

Trichuriasis can be diagnosed when T. trichiura eggs are detected in stool examination. Eggs will appear barrel-shaped and unembryonated, having bipolar plugs and a smooth shell.{{cite web |url= http://www.wrongdiagnosis.com/medical/trichuris_trichiura.htm |title= Trichuris trichiura |publisher= WrongDiagnosis.com |date= 2009-05-06 |access-date= 2009-05-19 |url-status= live |archive-url= https://web.archive.org/web/20040619123103/http://www.wrongdiagnosis.com/medical/trichuris_trichiura.htm |archive-date= 2004-06-19 }} Rectal prolapse can be diagnosed easily using defecating proctogram and is one of many methods for imaging the parasitic infection. Sigmoidoscopies show characteristic white bodies of adult worms hanging from inflamed mucosa ("coconut cake rectum").{{Cite book |last1=Viswanath |first1=A |last2=Yarrarapu |first2=SNS |last3=Williams |first3=M |date=26 June 2018 |title=Trichuris trichiura Infection |pmid=29939620}}

Limited access to essential medicine has made the eradication of trichuriasis worldwide challenging. Also, it is a public health concern that rates of post-treatment re-infection need to be determined and addressed to diminish the incidence of untreated re-infection. Lastly, with mass drug administration strategies improved diagnosis, and prompt treatment, the detection of an emergence of antihelminthic drug resistance should be examined.{{citation needed|date=May 2021}}

Mass Drug Administration (preventative chemotherapy) has had a positive effect on the disease burden of trichuriasis in East and West Africa, especially among children, who are at highest risk for infection.{{citation needed|date=March 2023}}

Infection can be avoided by proper disposal of human feces, avoiding fecal contamination of food, not eating soil, and avoiding crops fertilized with untreated human feces. Simple and effective proper hygiene such as washing hands and food is recommended for control.{{Cite journal |last=Behniafar |first=Hamed |last2=Sepidarkish |first2=Mahdi |last3=Tadi |first3=Mehrdad Jafari |last4=Valizadeh |first4=Soghra |last5=Gholamrezaei |first5=Mostafa |last6=Hamidi |first6=Faezeh |last7=Pazoki |first7=Hossein |last8=Alizadeh |first8=Faezeh |last9=Kianifard |first9=Nazanin |last10=Nooshabadi |first10=Morteza Sheikhi |last11=Bagheri |first11=Kimia |last12=Hemmati |first12=Faezeh |last13=Hemmati |first13=Taha |last14=Tori |first14=Neda Ahmazadeh |last15=Siddiq |first15=Abdelmonem |date=2024-05-01 |title=The global prevalence of Trichuris trichiura infection in humans (2010-2023): A systematic review and meta-analysis |url=https://linkinghub.elsevier.com/retrieve/pii/S187603412400056X |journal=Journal of Infection and Public Health |volume=17 |issue=5 |pages=800–809 |doi=10.1016/j.jiph.2024.03.005 |issn=1876-0341|doi-access=free }}

Improved facilities for feces disposal have decreased the incidence of whipworm. Handwashing before food handling, and avoiding ingestion of soil by thorough washing of food that may have been contaminated with egg-containing soil are other preventive measures. In addition to washing, it is also advisable to peel and/or cook fruits and vegetables. Improvement of sanitation systems, as well as improved facilities for feces disposal, have helped to limit defecation onto soil and contain potentially infectious feces from bodily contact.{{cite web |title=Prevention & Control |url=https://www.cdc.gov/parasites/whipworm/prevent.html |website=Parasites - Trichuriasis (also known as Whipworm Infection) |date=25 April 2019 |publisher=Centers for Disease Control and Prevention |access-date=27 October 2022}}

A study in a Brazilian urban centre demonstrated a significant reduction in the prevalence and incidence of soil-transmitted helminthiasis, including trichuriasis, following the implementation of a citywide sanitation program. A 33% reduction in the prevalence of trichuriasis and a 26% reduction in the incidence of trichuriasis was found in a study performed on 890 children ages 7–14 years old within 24 different sentinel areas chosen to represent the varied environmental conditions throughout the city of Salvador, Bahia, Brazil. Control of soil fertilizers has helped eliminate the potential for contact with human fecal matter and fertilizer in the soil.

Trichuriasis is treated with benzimidazole anthelmintic agents such as albendazole or mebendazole, sometimes in conjunction with other medications.{{citation needed|date=March 2023}}

Mebendazole is 90% effective in the first dose. Higher clearance rates can be obtained by combining mebendazole or albendazole with ivermectin.{{cite journal |journal= Clin Infect Dis |year=2010 |volume=51 |issue=12 |pages=1420–8 |title= Albendazole and mebendazole administered alone or in combination with ivermectin against Trichuris trichiura: a randomized controlled trial |pmid= 21062129 |doi= 10.1086/657310 |vauthors=Knopp S, Mohammed KA, Speich B, etal |doi-access=free }} The safety of ivermectin in children under {{cvt|15|kg}} and pregnant women has not yet been established.

In people with diarrhea, loperamide may be added to increase the contact time between anthelmintic agents and the parasites. Oral iron supplementation may be useful in treating the iron-deficiency anemia which often accompanies trichuriasis.{{citation needed|date=March 2023}}

File:Trichuriasis world map - DALY - WHO2004.svg for trichuriasis per 100,000 inhabitants in 2004{{Div col|small=yes|colwidth=10em}}

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Infection of T. trichiura is most frequent in areas with tropical weather and poor sanitation practices. Trichuriasis occurs frequently in areas in which untreated human feces is used as fertilizer or where open defecation takes place. Trichuriasis infection prevalence is 50 to 80 percent in some regions of Asia (noted especially in China and Korea) and also occurs in rural areas of the southeastern United States.{{citation needed|date=May 2021}}

T. trichiura is the third most common nematode (roundworm) infecting humans. Infection is most prevalent among children, and in North America, infection occurs frequently in immigrants from tropical or sub-tropical regions. It is estimated that 600–800 million people are infected worldwide, with 3.2 billion individuals at risk because they live in regions where this intestinal worm is common.{{citation needed|date=May 2021}}

The first written record of T. trichiura was made by the Italian anatomist Giovanni Battista Morgagni, who identified the presence of the parasite in a case of worms residing in the colon in 1740.{{citation needed|date=October 2017}} An exact morphological description and accurate drawings were first recorded in 1761 by Johann Georg Roederer, a German physician.{{citation needed|date=October 2017}} Soon after, the name Trichuris trichiura was given to this species.

Human whipworm, trichocephaliasis, and tricuriasis are all synonyms for trichuriasis, human infection of the T. trichiura intestinal nematode. In Spanish, trichuriasis is called tricuriasis, while it is known as trichuriose in French and Peitschenwurmbefall in German.{{citation needed|date=May 2021}}

Development of subunit vaccines requires the identification of protective antigens and their formulation in a suitable adjuvant. Trichuris muris is an antigenically similar laboratory model for T. trichiura. Subcutaneous vaccination with adult excretory-secretory products (ES) protects susceptible mouse strains from T. muris. Larval stages may contain novel and more relevant antigens which when incorporated in a vaccine induce worm expulsion earlier in infection than the adult worm products. Nematode vaccines marketed to date have been of the irradiated larval type and used exclusively for the treatment of animals. These vaccines are unstable and require annual production, involving the yearly production and sacrifice of donor animals for passage. There has been much interest in producing subunit vaccines against human and agricultural parasites since the early 1980s. Development of subunit vaccines requires the identification of protective antigens and their formulation with a suitable adjuvant to stimulate the immune response appropriately.{{citation needed|date=July 2020}}

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{{Medical condition classification and resources

| ICD11 = {{ICD11|1F6G}}

| ICD10 = {{ICD10|B|79||b|65}}

| ICD9 = {{ICD9|127.3}}

| ICDO =

| OMIM =

| DiseasesDB = 31146

| MedlinePlus = 001364

| eMedicineSubj =

| eMedicineTopic =

| MeshID = D014257

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{{Helminthiases}}

Category:Helminthiases

Category:Tropical diseases

Category:Parasitic diseases

Category:Parasitic nematodes of humans

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Category:Wikipedia infectious disease articles ready to translate