user:alteripse/AAT

Review of current therapies. {{cite journal | author = Abusrilwill H, Stockley RA | title = Alpha-1-antitrypsin deficiency replacement therapy: current status. | journal = Curr Opinion Pulm Med | volume = 12 | issue = | pages = 125-31 | year = | id = {{PMID|16456382}}}}

Genetics. {{cite journal | author = DeMeo DL, Silverman EK | title = α1-antitrypsin deficiency 2: Genetic aspects of α1-antitrypsin deficiency: phenotypes and genetic modifiers of emphysema risk. | journal = Thorax | volume = 59 | issue = | pages = 259-64 | year = 2004 | id = {{PMID|14985567}}}}

Prospects for gene therapy. {{cite journal | author = Driskell RA, Engelhardt JF | title = Current status of gene therapy for inherited lung diseases. | journal = Ann Rev Physiol | volume = 65 | issue = | pages = 585-612 | year = 2003 | id = {{PMID|12524461}}}}

Molecular pathophysiology. {{cite journal | author = Lomas DA, Parfrey H | title = α1-antitrypsin deficiency 4: Molecular pathophysiology. | journal = Thorax | volume = 365 | issue = | pages = 529-35 | year = 2004 | id = {{PMID|15170041}}}}

Possible advantages of AAT. {{cite journal | author = Lomas DA | title = The selective advantage of α1-antitrypsin deficiency. | journal = Am J Resp Crit Care Med | volume = 173 | issue = | pages = 1072-7 | year = 2006 | id = {{PMID|16439713}}}}

Epidemiology. {{cite journal | author = Luisetti M, Seersholm N | title = α1-antitrypsin deficiency 1: Epidemiology of alpha1-antitrypsin deficiency. | journal = Thorax | volume = 59 | issue = | pages = 164-9 | year = 2004 | id = {{PMID|14760160}}}}

Abnormal AAT accumulation attracts neutrophils. {{cite journal | author = Mulgrew AT, Taggart CC, Lawless MW, Greene CM, Brantly ML, O'Neill SJ, McElvaney NG | title = Z alpha1-antitrypsin polymerizes in the lung and acts as a neutrophil chemoattractant. | journal = Chest | volume = 125 | issue = 5 | pages = 1607-9 | year = 2004 | id = {{PMID|15136365}}}}

Clinical manifestations and natural history. {{cite journal | author = Needham M, Stockley RA | title = α1-antitrypsin deficiency 3: Clinical manifestations and natural history. | journal = Thorax | volume = 59 | issue = | pages = 441-5 | year = 2004 | id = {{PMID|15115878}}}} xxx

Liver aspects of AAT. {{cite journal | author = Perlmutter DH | title = Alpha1-antitrypsin deficiency: diagnosis and treatment. | journal = Clin Liver Dis | volume = 8 | issue = | pages = 839-59 | year = 2004| id = {{PMID|15464658}}}}

AAT in 26 year olds. {{cite journal | author = Piitulainen E, Carlson J, Ohlsson K, Sveger T | title = α1-antitrypsin deficiency in 26-year-old subjects: lung, liver, and protease/protease inhibitor studies. | journal = Chest | volume = 128 | issue = | pages = 2076-81 | year = 2005| id = {{PMID|16236857}}}}

New treatments. {{cite journal | author = Sandhaus RA | title = α1-antitrypsin deficiency 6: New and emerging treatments for α1-antitrypsin deficiency. | journal = Thorax | volume = 365 | issue = | pages = 904-9 | year = 2004 | id = {{PMID|15454659}}}}

Risk modification. {{cite journal | author = Senn O, Russi EW, Imboden M, Probst-Hensch NM | title = α1-Antitrypsin deficiency and lung disease: risk modification by occupational and environmental inhalants. | journal = Eur Resp J | volume = 26 | issue = 5 | pages = 909-17 | year = 2005 | id = {{PMID|16264055}}}}

CT scanning for monitoring. {{cite journal | author = Shaker SB, Stavngaard T, Stolk J, Stoel B, Dirksen A | title = α1-antitrypsin deficiency 7: Computed tomographic imaging in α1-antitrypsin deficiency. | journal = Thorax | volume = 59 | issue = | pages = 986-91 | year =2004 | id = {{PMID|15516477}}}}

Gene therapy for AAT; recent attempts. {{cite journal | author = Stecenko AA, Brigham KL | title = Gene therapy progress and prospects: α1-antitrypsin. | journal = Gene therapy | volume = 10 | issue = 2 | pages = 95-9 | year =2003 | id = {{PMID|12571637}}}}

Perspectives on treatments as of 2000. {{cite journal | author = Stockley RA | title = Alpha1-antitrypsin deficiency: what next. | journal = Thorax | volume = 55 | issue = | pages = 614-8 | year = 2000 | id = PMID xxxx}}

New perspective on pathophysiology: damage results from overload as well as deficiency. {{cite journal | author = Stockley RA | title = Alpha1-antitrypsin: more than just deficiency. | journal = Thorax | volume = 59 | issue = 5 | pages = 363-4 | year = 2004 | id = {{PMID|15115856}}}}

Monitoring with CT. {{cite journal | author = Stolk J, Ng WH, Bakker ME, Reiber JHC, Rabe KF, Putter H, Stoel BC | title = Correlation between annual change in health status and computer tomography derived lung density in subjects with α1-antitrypsin deficiency. | journal = Thorax | volume = 58 | issue = | pages = 1027-30 | year = 2003 | id = PMID xxxx}}

Brief review and intro to thorax review series. {{cite journal | author = Stoller JK | title = α1-antitrypsin deficiency. | journal = Thorax | volume = 59 | issue = 2 | pages = 92-3 | year = 2004 | id = {{PMID|14760142}}}}

Current iv therapies for AAT. {{cite journal | author = Stoller JK, Aboussouan LS | title = α1-antitrypsin deficiency 5: Intravenous augmentation therapies: current understanding. | journal = Thorax | volume = 59 | issue = | pages = 708-12 | year = 2004 | id = {{PMID|15282394}}}}

Lancet review already cited. {{cite journal | author = Stoller J, Aboussouan L | title = Alpha1-antitrypsin deficiency. | journal = Lancet | volume = 365 | issue = 9478 | pages = 2225-36 | year = | id = {{PMID|15978931}}}} xxx

Mortality is earlier mainly due to lung and liver disease. {{cite journal | author = Stoller JK, Tomashefski J, Crystal RG, Arroliga A, Strange C, Killian DN, Schluchter MD, Wiedemann HP | title = Mortality in individuals with severe deficiency of α1-antitrypsin: findings from the National Heart, Lung, and Blood Institute Registry. | journal = Chest | volume = 127 | issue = | pages = 1196-1204 | year = 2005 | id = {{PMID|15821195}}}}

Delayed diagnosis. {{cite journal | author = Stoller JK, Sandhaus RA, Turino G, Dickson R, Rodgers K, Strange C | title = Delay in diagnosis of alpha1-antitrypsin deficiency: a continuing problem. | journal = Chest | volume = 128 | issue = 4 | pages = 1989-94 | year = 2005 | id = {{PMID|16236846}}}}

Alpha-1 foundation. {{cite journal | author = Walsh JW, Snider GL, Stoller JK | title = A review of the alpha-1 foundation: its formation, impact, and critical success factors. | journal = Resp Care | volume = 51 | issue = 5 | pages = 526-31 | year = 2006 | id = {{PMID|16638163}}}}

More than a PI imbalance? {{cite journal | author = Wewers MD | title = α1-Antitrypsin deficiency: more than a protease imbalance? | journal = Chest | volume = 125 | issue = | pages = 1607-9 | year = 2004 | id = {{PMID|15136365}}}}

AAT in 86 yr old, cirrhosis, no emphysema, normal life expectancy. {{cite journal | author = Willson AB, Seow C, Zimmerman M | title = Severe alpha-1 antitrypsin deficiency diagnosed n an 86-year-old man. | journal = Internal Med J | volume = 34 | issue = | pages = 653 | year = | id = {{PMID|15546465}}}}