vas deferens

Vas deferens is Latin, meaning "carrying-away vessel" while ductus deferens, also Latin, means "carrying-away duct".{{cite journal |last1=Pozor |first1=Malgorzata |title=Seminal Vesiculitis |journal=Comparative Veterinary Anatomy |date=2022 |pages=825–833 |doi=10.1016/B978-0-323-91015-6.00067-4|isbn=9780323910156 |s2cid=245049526 }}

The human vas deferens measures 30–35 cm in length, and 2–3 mm in diameter.{{Cite book |url=https://www.worldcat.org/oclc/1201341621 |title=Gray's anatomy : the anatomical basis of clinical practice |date=2021 |others=Susan Standring |isbn=978-0-7020-7707-4 |edition=Forty-second |location=[New York] |oclc=1201341621}}{{Rp|page=1297}} It is continuous proximally with the tail of the epididymis,{{Rp|page=1296}} and exhibits a tortuous, convoluted initial/proximal section (which measures 2–3 cm in length). Distally, it forms a dilated and tortuous segment termed the ampulla of vas deferens before ending{{Rp|page=1297}} by uniting with a duct of the seminal vesicle to form the ejaculatory duct.{{cite journal |last1=Gonzales |first1=GF |title=Function of seminal vesicles and their role on male fertility. |journal=Asian Journal of Andrology |date=December 2001 |volume=3 |issue=4 |pages=251–8 |pmid=11753468}} Together they form part of the spermatic cord.{{Cite book|last=Liu|first=Longfei|url=https://doi.org/10.1016/B978-0-12-815008-5.00001-7|title=Scrotoscopic Surgery|publisher=Academic Press|year=2019|isbn=978-0-12-815008-5|pages=1–8|chapter=Chapter 1 - Applied Anatomy of the Scrotum and its Contents|doi=10.1016/B978-0-12-815008-5.00001-7|s2cid=81721236 }}

The vasa deferentia are supplied with blood by accompanying arteries, the (arteries of vas deferens). These arteries normally arises from the superior (sometimes inferior) vesical arteries, a branch of the internal iliac arteries.{{Gray's|inline=1|page=615}}

The vas deferens receives innervation from an autonomic plexus of post-ganglionic sympathetic fibres derived from the inferior hypogastric plexus.{{Rp|page=1297}}

It is innervated by a variety of nerve endings, although of the efferent nerves the sympathetic innveration dominates. Adrenergic junctions (those which release noradrenaline) are found in the smooth muscle layers.{{Cite journal|last1=Mirabella|first1=Nicola|last2=Squillacioti|first2=Caterina|last3=Varricchio|first3=Ettore|last4=Genovese|first4=Angelo|last5=Paino|first5=Giuseppe|date=2003-05-01|title=Innervation of vas deferens and accessory male genital glands in the water buffalo (Bubalus bubalis): Neurochemical characteristics and relationships to the reproductive activity|url=https://www.sciencedirect.com/science/article/abs/pii/S0093691X02012608|journal=Theriogenology|language=en|volume=59|issue=9|pages=1999–2016|doi=10.1016/S0093-691X(02)01260-8|pmid=12600736|issn=0093-691X|via=Elsevier|url-access=subscription}} Cholinergic synapses and vasoactive intestinal peptide synapses are found in the connective tissue of the mucosa.{{Cite journal |last=Alm |first=Per |date=1982-07-01 |title=On the autonomic innervation of the human vas deferens |url=https://www.sciencedirect.com/science/article/abs/pii/0361923082901721 |journal=Brain Research Bulletin |language=en |publisher=Elsevier |volume=9 |issue=1–6 |pages=673–677 |doi=10.1016/0361-9230(82)90172-1 |issn=0361-9230 |pmid=6184134 |s2cid=4761228|url-access=subscription }}

Within the spermatic cord, the vas deferens is situated posterior (and parallel to) the vessels of the spermatic cord.{{Rp|page=1297}}

The vas deferens traverses the inguinal canal to reach the pelvic cavity; it enters the pelvic cavity lateral to the inferior epigastric vessels. At the deep inguinal ring, the vas deferens diverges from the testicular vessels to pass medially to reach the base of the prostate posteriorly.{{Rp|page=1297}}

The vas deferens consists of an external adventitial sheath containing blood vessels and nerves, a muscular middle layer composed of three layers of smooth muscle (with a circular muscle layer interposed between two longitudinal muscle layers), and an internal mucosal lining consisting of pseudostratified columnar epithelium (which bears the non-motile stereocilia).{{Cite journal |last1=Höfer |first1=D. |last2=Drenckhahn |first2=D. |date=May 1996 |title=Cytoskeletal differences between stereocilia of the human sperm passageway and microvilli/stereocilia in other locations |journal=The Anatomical Record |volume=245 |issue=1 |pages=57–64 |doi=10.1002/(SICI)1097-0185(199605)245:1<57::AID-AR10>3.0.CO;2-8 |issn=0003-276X |pmid=8731041|s2cid=7457415 |doi-access=free }}

The vas deferens has the greatest muscle-to-lumen ratio of any hollow organ.{{Rp|page=1297}}

During ejaculation, the smooth muscle in the walls of the vas deferens contracts reflexively, thus propelling the sperm forward. This is also known as peristalsis.{{Cite journal | doi=10.1113/jphysiol.2008.160440| pmid=18787034| pmc=2652144|title = Smooth muscle cell calcium activation mechanisms| journal=The Journal of Physiology| volume=586| issue=21| pages=5047–5061|year = 2008|last1 = Berridge|first1 = Michael J.}} The epithelial sodium channel ENaC is strongly expressed in smooth muscle cells of the vas deferens. It has been suggested that ENaC functions as a mechanosensor in vascular smooth muscle cells that initiate pressure‐induced constriction known as the "myogenic response". Ion channels ENaC and CFTR, aquaporin of type AQP9 are localized on the apical border of the epithelia. Thus, these channels are involved concurrently in the regulation of fluid and electrolyte balance in the lumen of the vas deferens.

The sperm are transferred from each vas deferens into the urethra, partially mixing with secretions from the male accessory sex glands such as the seminal vesicles, prostate gland and the bulbourethral glands, which form the bulk of semen.{{Cite book |author=Mann, T |year=1954 |title=The Biochemistry of Semen |publisher=London: Methuen & Co; New York: John Wiley & Sons |url= https://archive.org/stream/biochemistryofse00mann#page/n5/mode/2up |access-date=November 9, 2013}}

Damage to the vas deferens during inguinal hernia repair may cause infertility.{{Cite book |title=Schwartz's Principles of Surgery |edition=11th |publication-date=2019 |pages=1620}}

A vasectomy is a method of contraception in which the vasa deferentia are permanently cut. In some cases, it can be reversed. A modern variation, vas-occlusive contraception, involves injecting an obstructive material into the ductus to block the flow of sperm.{{cite journal |doi=10.1002/14651858.CD003991.pub4 |pmid=24683020 |title=Vasectomy occlusion techniques for male sterilization |journal=Cochrane Database of Systematic Reviews |issue=3 |pages=CD003991 |year=2014 |last1=Cook |first1=Lynley A |last2=Van Vliet |first2=Huib AAM |last3=Lopez |first3=Laureen M |last4=Pun |first4=Asha |last5=Gallo |first5=Maria F |volume=2014 |pmc=7173716 }}

The vas deferens may be obstructed, or it may be completely absent in a condition known as congenital absence of the vas deferens (CAVD, a potential feature of cystic fibrosis), causing male infertility. Acquired obstructions can occur due to infections. To treat these causes of male infertility, sperm can be harvested by testicular sperm extraction (TESE) or microsurgical epididymal sperm aspiration (MESA).{{cite journal |last1=Schroeder-Printzen |first1=I. |title=Microsurgical epididymal sperm aspiration: aspirate analysis and straws available after cryopreservation in patients with non-reconstructable obstructive azoospermia |journal=Human Reproduction |date=1 December 2000 |volume=15 |issue=12 |pages=2531–2535 |doi=10.1093/humrep/15.12.2531|pmid=11098022 |doi-access=free }}

The vas deferens has a dense sympathetic innervation,{{cite journal|last1=Sjöstrand|first1=N.O.|title=The adrenergic innervation of the vas deferens and the accessory male genital organs|journal=Acta Physiologica Scandinavica|date=1965|volume=257|page=S1–82|url=https://apps.dtic.mil/sti/citations/AD0626660}} making it a useful system for studying sympathetic nerve function and for studying drugs that modify neurotransmission.{{Cite journal

| pmid = 20074819

| year = 2010

| last1 = Burnstock

| first1 = G

| title = Vas deferens--a model used to establish sympathetic cotransmission

| journal = Trends in Pharmacological Sciences

| volume = 31

| issue = 3

| pages = 131–9

| last2 = Verkhratsky

| first2 = A

| doi = 10.1016/j.tips.2009.12.002

}}

It has been used:

• as a bioassay for the discovery of enkephalins, the endogenous opiates.{{Cite journal

| pmid = 1207728

| year = 1975

| last1 = Hughes

| first1 = J

| title = Identification of two related pentapeptides from the brain with potent opiate agonist activity

| journal = Nature

| volume = 258

| issue = 5536

| pages = 577–80

| last2 = Smith

| first2 = T. W.

| last3 = Kosterlitz

| first3 = H. W.

| last4 = Fothergill

| first4 = L. A.

| last5 = Morgan

| first5 = B. A.

| last6 = Morris

| first6 = H. R.

| doi=10.1038/258577a0

| bibcode = 1975Natur.258..577H

| s2cid = 95411

}}

• to demonstrate quantal transmission from sympathetic nerve terminals.{{Cite journal

| pmid = 2882426

| year = 1987

| last1 = Brock

| first1 = J. A.

| title = Relationship between the nerve action potential and transmitter release from sympathetic postganglionic nerve terminals

| journal = Nature

| volume = 326

| issue = 6113

| pages = 605–7

| last2 = Cunnane

| first2 = T. C.

| doi = 10.1038/326605a0

| bibcode = 1987Natur.326..605B

| s2cid = 4303337

}}

• as the first direct measure of free Ca²⁺ concentration in a postganglionic nerve terminal.{{Cite journal

| pmid = 9279805

| year = 1997

| last1 = Brain

| first1 = K. L.

| title = Calcium in sympathetic varicosities of mouse vas deferens during facilitation, augmentation and autoinhibition

| journal = The Journal of Physiology

| volume = 502

| pages = 521–36

| last2 = Bennett

| first2 = M. R.

| pmc = 1159525

| issue=3

| doi=10.1111/j.1469-7793.1997.521bj.x

}}

• to develop an optical method for monitoring packeted transmission (similar to quantal transmission).{{Cite journal

| pmid = 12068045

| year = 2002

| last1 = Brain

| first1 = K. L.

| title = Intermittent ATP release from nerve terminals elicits focal smooth muscle Ca2+ transients in mouse vas deferens

| journal = The Journal of Physiology

| volume = 541

| issue = Pt 3

| pages = 849–62

| last2 = Jackson

| first2 = V. M.

| last3 = Trout

| first3 = S. J.

| last4 = Cunnane

| first4 = T. C.

| pmc = 2290369

| doi=10.1113/jphysiol.2002.019612

}}

Most vertebrates have some form of duct to transfer the sperm from the testes to the urethra. In cartilaginous fish and amphibians, sperm are carried through the archinephric duct, which also partially helps to transport urine from the kidneys. In teleosts, there is a distinct sperm duct, separate from the ureters, and often called the vas deferens, although probably not truly homologous with that in humans.{{cite book |author=Romer, Alfred Sherwood|author2=Parsons, Thomas S.|year=1977 |title=The Vertebrate Body |publisher=Holt-Saunders International |location= Philadelphia, PA|pages= 393–395|isbn= 978-0-03-910284-5}} The vas deferens loops over the ureter in placental mammals, but not in marsupial mammals.{{cite book|author=C. Hugh Tyndale-Biscoe|title=Life of Marsupials|url=https://books.google.com/books?id=KqtlPZJ9y8EC&q=%22vas+deferens%22|year=2005|publisher=Csiro Publishing|isbn=978-0-643-06257-3}}{{cite book|author1=Patricia J. Armati|author2=Chris R. Dickman|author3=Ian D. Hume|title=Marsupials|url=https://books.google.com/books?id=x3S5v971Nk0C&q=%22vas+deferens%22|date=17 August 2006|publisher=Cambridge University Press|isbn=978-1-139-45742-2}}

In cartilaginous fishes, the part of the archinephric duct closest to the testis is coiled up to form an epididymis. Below this are a number of small glands secreting components of the seminal fluid. The final portion of the duct also receives ducts from the kidneys in most species.

In amniotes (mammals, birds, and reptiles), the archinephric duct has become a true vas deferens, and is used only for conducting sperm, never urine. As in cartilaginous fish, the upper part of the duct forms the epididymis. In many species, the vas deferens ends in a small sac for storing sperm.

The only vertebrates to lack any structure resembling a vas deferens are the primitive jawless fishes, which release sperm directly into the body cavity, and then into the surrounding water through a simple opening in the body wall.

File:Illu repdt male.jpg|Male reproductive system.

File:Gray402.png|Coronal section of pelvis, showing arrangement of fasciae. Viewed from behind.

File:Gray547.png|The relations of the femoral and abdominal inguinal rings, seen from within the abdomen. Right side.

File:Gray1146.png|The spermatic cord in the inguinal canal.

File:Gray1152.png|Fundus of the bladder with the vesiculae seminales.

File:Gray1156.png|Vertical section of bladder, penis, and urethra.

File:Gray1160.png|Prostate with seminal vesicles and seminal ducts, viewed from in front and above.

File:Illu quiz prostate01.jpg|Prostate

File:Vas deferens.jpg|Microscopic cross section.

File:Testis, spermatic vessels and vas deferens 2.jpg|Testis, spermatic vessels and vas deferens

File:Slide2UMR.JPG|A deep dissection showing the vas deferens.

{{Anatomy-terms}}

• Intra vas device
• Excretory duct of seminal gland
• Vas deferens in the reproductive system of gastropods

{{Reflist}}

{{Commons category}}

• {{SUNYAnatomyLabs|36|07|03|01}}—"Inguinal Region, Scrotum and Testes: Layers of the Spermatic Cord"
• {{SUNYAnatomyLabs|44|02|03|01}}—"The Male Pelvis: Distribution of the Peritoneum in the Male Pelvis"
• {{MedicalMnemonics|2424|319||}} {{dead link|date=November 2015}}
• {{ViennaCrossSection|pelvis/pelvis-e12-15}}
• {{NormanAnatomy|inguinalregion}} ({{NormanAnatomyFig|testes}})

{{Male reproductive system}}

{{Authority control}}

Category:Human male reproductive system

Category:Mammal male reproductive system

Category:Scrotum

Category:Sex organs