(−)-germacrene D synthase

{{Short description|Class of enzymes}}

{{Infobox enzyme

| Name = (−)-germacrene D synthase

| EC_number = 4.2.3.75

| CAS_number =

| GO_code =

| image =

| width =

| caption =

}}

(−)-Germacrene D synthase (EC 4.2.3.75) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase ((−)-germacrene-D-forming).{{cite journal | vauthors = Schmidt CO, Bouwmeester HJ, Franke S, König WA | title = Mechanisms of the biosynthesis of sesquiterpene enantiomers (+)- and (−)-germacrene D in Solidago canadensis |journal = Chirality |year = 1999 |volume = 11 | issue = 5–6 |pages = 353–362 |doi=10.1002/(sici)1520-636x(1999)11:5/6<353::aid-chir2>3.0.co;2-l}}{{cite journal | vauthors = He X, Cane DE | title = Mechanism and stereochemistry of the germacradienol/germacrene D synthase of Streptomyces coelicolor A3(2) | journal = Journal of the American Chemical Society | volume = 126 | issue = 9 | pages = 2678–9 | date = March 2004 | pmid = 14995166 | doi = 10.1021/ja039929k }}{{cite journal | vauthors = Lücker J, Bowen P, Bohlmann J | title = Vitis vinifera terpenoid cyclases: functional identification of two sesquiterpene synthase cDNAs encoding (+)-valencene synthase and (-)-germacrene D synthase and expression of mono- and sesquiterpene synthases in grapevine flowers and berries | journal = Phytochemistry | volume = 65 | issue = 19 | pages = 2649–59 | date = October 2004 | pmid = 15464152 | doi = 10.1016/j.phytochem.2004.08.017 }}{{cite journal | vauthors = Prosser I, Altug IG, Phillips AL, König WA, Bouwmeester HJ, Beale MH | title = Enantiospecific (+)- and (-)-germacrene D synthases, cloned from goldenrod, reveal a functionally active variant of the universal isoprenoid-biosynthesis aspartate-rich motif | journal = Archives of Biochemistry and Biophysics | volume = 432 | issue = 2 | pages = 136–44 | date = December 2004 | pmid = 15542052 | doi = 10.1016/j.abb.2004.06.030 }} This enzyme catalyses the following chemical reaction

: (2E,6E)-farnesyl diphosphate $\backslash rightleftharpoons$ (−)-germacrene D + diphosphate

In Solidago canadensis the biosynthesis results in the pro-R hydrogen at C-1 of the farnesyl diphosphate ending up at C-11 of the (−)-germacrene D .