:Bisdemethoxycurcumin

{{Chembox

| ImageFile = Bisdemethoxycurcumin.png

| ImageSize = 200px

| ImageAlt =

| PIN = (1E,6E)-1,7-Bis(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione

| OtherNames = Curcumin III, bis(4-hydroxycinnamoyl)methane, didemethoxycurcumin, bisdemethoxycurcumin, Bis(p-hydroxycinnamoyl)methane, NSC687839

|Section1={{Chembox Identifiers

| CASNo = 24939-16-0

| PubChem = 5315472

| ChemSpiderID = 4474770

| SMILES = C1=CC(=CC=C1C=CC(=O)CC(=O)C=CC2=CC=C(C=C2)O)O

| InChI = 1S/C19H16O4/c20-16-7-1-14(2-8-16)5-11-18(22)13-19(23)12-6-15-3-9-17(21)10-4-15/h1-12,20-21H,13H2/b11-5+,12-6+

| InChIKey = PREBVFJICNPEKM-YDWXAUTNSA-N

}}

|Section2={{Chembox Properties

| C=19 | H=16 | O=4

| Appearance =

| Density = 1.285 g/cm³

| MeltingPtC = 226 to 231

| MeltingPt_ref =

| BoilingPt =

| Solubility = }}

|Section3={{Chembox Hazards

| MainHazards =

| FlashPt =

| AutoignitionPt = }}

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Bisdemethoxycurcumin is a curcuminoid found (along with the curcuminoids curcumin and demethoxycurcumin) in turmeric (Curcuma longa), but absent in Javanese turmeric (Curcuma xanthorrhiza).{{cite book|author=T. K. Lim|title=Edible Medicinal and Non-Medicinal Plants: Volume 12 Modified Stems, Roots, Bulbs|url=https://books.google.com/books?id=d42RCwAAQBAJ&pg=PA374|date=11 February 2016|publisher=Springer|isbn=978-3-319-26065-5|page=374}} Bisdemethoxycurcumin is used as a pigment and nutraceutical with antimutagenic properties.{{cite book|author1=Hajime Ohigashi|author2=Toshihiko Osawa|author3=Junji Terao|author4=Shaw Watanabe|author5= Toshikazu Yoshikawa|title=Food Factors for Cancer Prevention|url=https://books.google.com/books?id=hmryCAAAQBAJ&pg=PA251|date=27 November 2013|publisher=Springer Science & Business Media|isbn=978-4-431-67017-9|page=251}}{{cite book|author=Jun-Ping Xu|title=Cancer Inhibitors from Chinese Natural Medicines|url=https://books.google.com/books?id=K-mVDQAAQBAJ&pg=PA338|date=25 November 2016|publisher=CRC Press|isbn=978-1-4987-8766-6|page=338}} All three of the curcuminoids found in Curcuma longa have been shown to have antioxidant properties, but bisdemethoxycurcumin is more resistant than the others to alkaline degradation.{{cite book|author1=Francisco Delgado-Vargas|author2=Octavio Paredes-Lopez|title=Natural Colorants for Food and Nutraceutical Uses|url=https://books.google.com/books?id=zXLLBQAAQBAJ&pg=PA244|date=26 December 2002|publisher=CRC Press|isbn=978-1-4200-3171-3|page=244}} It was found to be effective in sensitizing PC cells resistance against gemcitabine.{{cite web |url=https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/bisdemethoxycurcumin |title=Bisdemethoxycurcumin |work=ScienceDirect |publisher=ScienceDirect |accessdate=5 October 2022 }}