:Dipeptidyl-dipeptidase

{{Infobox enzyme

| Name = Dipeptidyl-dipeptidase

| EC_number = 3.4.14.6

| CAS_number = 91608-92-3

| GO_code =

| image =

| width =

| caption =

}}

Dipeptidyl-dipeptidase ({{EC number|3.4.14.6}}, dipeptidyl tetrapeptide hydrolase, dipeptidyl ligase, tetrapeptide dipeptidase) is an enzyme.{{cite journal | title = Dipeptidyl tetrapeptide hydrolase, a new enzyme with dipeptidyl ligase activity | vauthors = Eng FW |journal = Can. J. Biochem. Cell Biol. |year = 1984 |volume = 62 | issue = 6 |pages = 516–528 | doi = 10.1139/o84-069 }} This enzyme catalyses the following chemical reaction

: Preferential release of dipeptides from a tetrapeptide, e.g. Ala-Gly!Ala-Gly. Acts more slowly on Ala-Ala!Ala-Ala and Gly-Gly!Gly-Gly

This thiol-activated peptidase is isolated from cabbage (Brassica oleracea).