:Setiptiline
{{Short description|Antidepressant drug}}
{{cs1 config|name-list-style=vanc}}
{{Drugbox
| Verifiedfields = changed
| verifiedrevid = 464389691
| IUPAC_name = 2-methyl-2,3,4,9-tetrahydro-1H-dibenzo[3,4:6,7]cyclohepta[1,2-c]pyridine
| image = Setiptiline 2D structure.svg
| width = 200px
| tradename = Tecipul
| Drugs.com = {{drugs.com|international|setiptiline}}
| pregnancy_category =
| legal_status = Rx-only
| routes_of_administration = Oral
| bioavailability =
| metabolism =
| elimination_half-life =
| excretion =
| CAS_number_Ref = {{cascite|changed|??}}
| CAS_number = 57262-94-9
| ATC_prefix = none
| ATC_suffix =
| ATC_supplemental =
| PubChem = 5205
| DrugBank_Ref = {{drugbankcite|changed|drugbank}}
| DrugBank = DB09304
| ChEBI = 135076
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 5016
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 7L38105Z6E
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D08511
| synonyms = Teciptiline; delta(13b,4a),4a-Carba-mianserin; MO-8282; ORG-8282
| C=19 | H=19 | N=1
| SMILES = c42c(\C3=C(/c1ccccc1C2)CN(C)CC3)cccc4
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C19H19N/c1-20-11-10-18-16-8-4-2-6-14(16)12-15-7-3-5-9-17(15)19(18)13-20/h2-9H,10-13H2,1H3
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = GVPIXRLYKVFFMK-UHFFFAOYSA-N
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Setiptiline (brand name Tecipul), also known as teciptiline, is a tetracyclic antidepressant (TeCA) that acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). It was launched in 1989 for the treatment of depression in Japan by Mochida.{{cite book | vauthors = Holenz J, Díaz JL, Buschmann H | chapter = Chemistry: Tricyclic and tetracyclic antidepressants | doi = 10.1002/9783527619337.ch5 | veditors = Buschmann H, Torrens A, Vela JM | chapter-url = https://books.google.com/books?id=yXD4QA-Y_Z0C&pg=PA248 | title = Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application | volume = 1 | page = 248 | publisher = Wiley VCH | year = 2007 | isbn = 978-3-527-31058-6 }}{{Dead link|date=March 2024 |bot=InternetArchiveBot |fix-attempted=yes }}{{ cite book | url = https://books.google.com/books?id=5GpcTQD_L2oC&pg=PA942 | title = Index Nominum 2000: International Drug Directory | page = 942 | editor = Swiss Pharmaceutical Society | publisher = Medpharm Scientific Publishers | year = 2000 | isbn = 3-88763-075-0 }}
Pharmacology
=Pharmacodynamics=
{{See also|Pharmacology of antidepressants|Tetracyclic antidepressant#Binding profiles}}
Setiptiline acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist,{{cite journal | vauthors = Przegaliński E, Baran L, Siwanowicz J, Rawłów A | title = The lack of antidepressant properties and a potent central antiserotonin activity of Org 8282 | journal = Polish Journal of Pharmacology and Pharmacy | volume = 38 | issue = 4 | pages = 377–384 | year = 1986 | pmid = 3774630 }} likely at the 5-HT2 subtypes,{{Citation needed|date=September 2017}} as well as an H1 receptor inverse agonist/antihistamine.{{Additional citation needed|date=September 2017}}
Chemistry
Setiptiline has a tetracyclic structure and is a close analogue of mianserin and mirtazapine, with setiptiline being delta(13b,4a),4a-carba-mianserin, and mirtazapine being 6-azamianserin.
See also
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References
{{Reflist}}
{{Antidepressants}}
{{Anxiolytics}}
{{Navboxes
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{{Adrenergic receptor modulators}}
{{Histamine receptor modulators}}
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{{Tricyclics}}
Category:H1 receptor antagonists
Category:Noradrenergic and specific serotonergic antidepressants
Category:Serotonin receptor antagonists
Category:Tetracyclic antidepressants
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