tetracyclic antidepressant

• Maprotiline (Ludiomil) – can also be classified as a TCA and grouped with the secondary amines
• Mianserin (Tolvon)
• Mirtazapine (Remeron)
• Setiptiline (Tecipul)

Drugs that contain four rings not all fused together but are sometimes still classified as TeCAs include:

• Amoxapine (Asendin) – often classified as a TCA and grouped with the secondary amines
• Quetiapine (Seroquel) - an atypical antipsychotic sometimes used as an adjunct antidepressant

• Benzoctamine (Tacitin) – a tetracyclic compound and is closely related to maprotiline, with the two compounds differing only in the length of their side chain, but benzoctamine is not used as an antidepressant and is instead used as an anxiolytic
• Loxapine (Adasuve, Loxitane) – a typical antipsychotic that produces amoxapine as a major metabolite and is said to have antidepressant effects, but it is not usually regarded as a TeCA

Drugs that contain four rings not all fused together but could still be classified as tetracyclic include:

• Mazindol (Mazanor, Sanorex) – a monoamine reuptake inhibitor used as an appetite suppressant and with potential antidepressant effects, but not classified as a TeCA

• Aptazapine (CGS-7525A) – a close analogue of mirtazapine
• Esmirtazapine (ORG-50,081) – the (S)-(+) enantiomer of mirtazapine
• Oxaprotiline (C 49-802 BDA) – a close analogue of maprotiline

Drugs that contain four rings not all fused together but could still be classified as tetracyclic include:

• Ciclazindol (WY-23,409) – a close analogue of mazindol

{{See also|Pharmacology of antidepressants}}

TeCAs have diverse pharmacology and differ from TCAs in a number of ways. With the exception of amoxapine, TeCAs do not inhibit the reuptake of serotonin{{Citation needed|date=July 2020}}. However, aside from mirtazapine, they do inhibit the reuptake of norepinephrine{{Citation needed|date=July 2020}}. TeCAs block the serotonin 5-HT₂ receptors similarly to TCAs. Besides mirtazapine, they also block the α₁-adrenergic receptor{{Citation needed|date=July 2020}}. Conversely, whereas TCAs have relatively low affinity for the α₂-adrenergic receptor, mianserin and mirtazapine potently antagonize this receptor, and this action is thought to be involved in their antidepressant effects{{Citation needed|date=July 2020}}. TeCAs block the histamine H₁ receptor similarly to the TCAs, but tend to be even stronger antihistamines than TCAs{{Citation needed|date=July 2020}}. On the other hand, in contrast to almost all TCAs, TeCAs have only low affinity for the muscarinic acetylcholine receptors, and for this reason, are associated with few or no anticholinergic side effects{{Citation needed|date=July 2020}}. Mianserin and mirtazapine are far less toxic than TCAs in overdose.{{Cite journal|last=Shaw|first=W. L.|date=1980-01-01|title=The comparative safety of mianserin in overdose|url=https://doi.org/10.1185/03007998009114803|journal=Current Medical Research and Opinion|volume=6|issue=sup7|pages=44–51|doi=10.1185/03007998009114803|issn=0300-7995|url-access=subscription}}{{Cite journal|last1=Waring|first1=W. Stephen|last2=Good|first2=Alison M.|last3=Bateman|first3=D. Nicholas|date=2007-01-01|title=Lack of significant toxicity after mirtazapine overdose: A five-year review of cases admitted to a regional toxicology unit|url=https://doi.org/10.1080/15563650601005837|journal=Clinical Toxicology|volume=45|issue=1|pages=45–50|doi=10.1080/15563650601005837|pmid=17357381 |s2cid=28546654 |issn=1556-3650|url-access=subscription}}

{{See also|Tricyclic antidepressant#Binding profiles}}

The binding profiles of various TeCAs in terms of their affinities ({{abbr|K_i|inhibitory constant}}, {{abbr|nM|nanomolar}}) for various receptors and transporters are as follows:{{cite web | title = PDSP K_i Database | work = Psychoactive Drug Screening Program (PDSP)|author1-link=Bryan Roth | author1 = Roth, BL | author2 = Driscol, J | publisher = University of North Carolina at Chapel Hill and the United States National Institute of Mental Health | access-date = 14 August 2017 | url = https://pdsp.unc.edu/databases/kidb.php}}

The TeCAs act as antagonists or inverse agonists of the receptors and as inhibitors of the transporters.

• List of antidepressants
• Noradrenergic and specific serotonergic antidepressant

{{Reflist|2}}

{{Antidepressants}}

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{{Adrenergic receptor modulators}}

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{{Tetracyclics}}

{{Chemical classes of psychoactive drugs}}

Category:Chemical classes of psychoactive drugs