2019–20 Copa Argentina#Round of 64

|attendance=

|referee=Carlos Córdoba

}}

{{footballbox collapsible

|date=March 3, 2021

|time=21:30

|team1=Boca Juniors

|score=2–1

|report=https://www.copaargentina.org/es/partido/3330_Boca-vs-Claypole.html

|team2= Claypole

|goals1=Villa {{goal|35}}
Maroni {{goal|76}}

|goals2=Landaburu {{goal|29}}

|stadium=Ciudad de Lanús – Néstor Díaz Pérez

|location=Lanús, Pcia. de Buenos Aires

|attendance=

|referee=Leandro Rey Hilfer

}}

{{footballbox collapsible

|date=March 10, 2021The match, originally scheduled to be played on March 17, 2020 was postponed due to the COVID-19 pandemic

|time=21:30

|team1=Independiente

|score=1–0

|report=https://www.copaargentina.org/es/partido/3346_Independiente-vs-Villa-Mitre.html

|team2= Villa Mitre

|goals1=S. Romero {{goal|45+1|pen.}}

|goals2=

|stadium=José María Minella

|location=Mar del Plata, Pcia. de Buenos Aires

|attendance=

|referee=Ariel Penel

}}

{{footballbox collapsible

|date=January 20, 2021

|time=19:20

|team1=Rosario Central

|score=0–3

|report=https://www.copaargentina.org/es/partido/3322_Rosario-Central-vs-Boca-Unidos.html

|team2= Boca Unidos

|goals1=

|goals2=Medina {{goal|1|pen.}}
Ríos {{goal|25}}
Ramírez {{goal|83|pen.}}

|stadium= Único de San Nicolás

|location=San Nicolás de los Arroyos, Pcia. de Buenos Aires

|attendance=

|referee=Hernán Mastrángelo

}}

{{footballbox collapsible

|date=February 23, 2021

|time=21:10

|team1=Lanús

|score=3–1

|report=https://www.copaargentina.org/es/partido/3337_Lanus-vs-Real-Pilar.html

|team2= Real Pilar

|goals1=Sand {{goal|47|pen.}}
Orozco {{goal|71}}
Orsini {{goal|90+1}}

|goals2=Crego {{goal|43}}

|attendance=

|referee=Nazareno Arasa

}}

{{footballbox collapsible

|date=February 25, 2020

|time=21:10

|team1=Gimnasia y Esgrima (LP)

|score=2–0

|report=https://www.copaargentina.org/es/partido/3338_Gimnasia-LP-vs-Sportivo-Barracas.html

|team2= Sportivo Barracas

|goals1=Licht {{goal|3}}
Cocimano {{goal|30}}

|goals2=

|stadium=Centenario Ciudad de Quilmes

|location=Quilmes, Pcia. de Buenos Aires

|attendance=Julio Barraza

|referee=

}}

{{footballbox collapsible

|date=February 17, 2021

|time=21:10

|team1=Vélez Sarsfield

|score=3–1

|report=https://www.copaargentina.org/es/partido/3321_Velez-vs-Deportivo-Camioneros.html

|team2= Deportivo Camioneros

|goals1=Galdames {{goal|6}}
De La Fuente {{goal|10}}
Brizuela {{goal|30}}

|goals2=Parisi {{goal|24|pen.}}

|attendance=

|referee=Julio Barraza

}}

{{footballbox collapsible

|date=January 28, 2021

|time=21:10

|team1=Arsenal

|score=0–1

|report=https://www.copaargentina.org/es/partido/3318_Arsenal-vs-Huracan-Las-Heras.html

|team2= Huracán Las Heras

|goals1=

|goals2=L. Agüero {{goal|63}}

|stadium=Ciudad de Caseros

|attendance=

|referee=Leandro Rey Hilfer

}}

{{footballbox collapsible

|date=March 11, 2020

|time=22:10

|team1=Argentinos Juniors

|score=1–0

|report=https://www.copaargentina.org/es/partido/3341_Argentinos-Juniors-vs-Canuelas.html

|team2= Cañuelas

|goals1=Hauche {{goal|5}}

|goals2=

|attendance=

|referee=Carlos Gariano

}}

{{footballbox collapsible

|date=February 25, 2021

|time=17:10

|team1=Huracán

|score=1–1

|report=https://www.copaargentina.org/es/partido/3334_Huracan-vs-Estudiantes-SL-.html

|team2= Estudiantes (SL)

|goals1=Mendoza {{goal|40}}

|goals2=Cesarini {{goal|25}}

|penalties1=Chávez {{pengoal}}
Briasco {{pengoal}}
Toranzo {{pengoal}}
Bonifacio {{pengoal}}
Mendoza {{penmiss}}
Pérez {{penmiss}}

|penaltyscore=4–5

|penalties2={{pengoal}} Gorgerino
{{pengoal}} Soloppi
{{pengoal}} Belfiore
{{penmiss}} Garro
{{pengoal}} Cesarini
{{pengoal}} Felice

|stadium=Coloso del Ruca Quimey

|location=Cutral Có, Pcia. de Neuquén

|attendance=

|referee=Silvio Trucco

}}

{{footballbox collapsible

|date=March 17, 2021

|time=19:25

|team1=Racing

|score=3–1

|report=https://www.copaargentina.org/es/partido/3325_Racing-Club-vs-Sportivo-Belgrano.html

|team2= Sportivo Belgrano

|goals1=Martínez {{goal|84}}
Copetti {{goal|85}}
Fértoli {{goal|90+2}}

|goals2=Argüello {{goal|55}}

|attendance=

|referee=Nazareno Arasa

}}

{{footballbox collapsible

|date=February 18, 2021

|time=21:10

|team1=San Lorenzo

|score=3–0

|report=https://www.copaargentina.org/es/partido/3326_San-Lorenzo-vs-Liniers.html

|team2= Liniers

|goals1=Díaz {{goal|7}}
Ó. Romero {{goal|53||79}}

|goals2=

|stadium=José María Minella

|location=Mar del Plata, Pcia. de Buenos Aires

|attendance=

|referee=Lucas Comesaña

}}

{{footballbox collapsible

|date=February 10, 2021

|time=21:10

|team1=River Plate

|score=4–0

|report=https://www.copaargentina.org/es/partido/3333_River-vs-Defensores-de-Pronunciamiento.html

|team2= Defensores (P)

|goals1=Suárez {{goal|15}}
Álvarez {{goal|34}}
Angileri {{goal|58}}
Girotti {{goal|77}}

|goals2=

|stadium=Florencio Sola

|attendance=

|referee=Germán Delfino

}}

{{footballbox collapsible

|date=March 4, 2020

|time=19:00

|team1=Estudiantes (LP)

|score=1–1

|report=https://www.copaargentina.org/es/partido/3342_Estudiantes-LP-vs-Deportivo-Laferrere.html

|team2= Laferrere

|goals1=F. González {{goal|32}}

|goals2=Faillace {{goal|40}}

|penalties1=Schunke {{pengoal}}
Estévez {{pengoal}}
Retegui {{penmiss}}
Díaz {{pengoal}}
García {{pengoal}}
Mascherano {{penmiss}}

|penaltyscore=4–5

|penalties2={{pengoal}} Scarnato
{{pengoal}} López
{{penmiss}} Benítez
{{pengoal}} Pintos
{{pengoal}} Barreal
{{pengoal}} Acuña

|stadium=Ciudad de Lanús – Néstor Díaz Pérez

|location=Lanús, Pcia. de Buenos Aires

|attendance=

|referee=Pablo Echavarría

}}

{{footballbox collapsible

|date=January 6, 2021

|time=19:10

|team1=Temperley

|score=0–0

|report=https://www.copaargentina.org/es/partido/3317_Temperley-vs-Deportivo-Riestra.html

|team2= Deportivo Riestra

|goals1=

|goals2=

|penalties1=Cólzera {{pengoal}}
Ellacopulos {{pengoal}}
Di Lorenzo {{penmiss}}
Muscio {{pengoal}}
Alonso {{pengoal}}

|penaltyscore=4–2

|penalties2={{pengoal}} Pereira
{{pengoal}} Ramírez Agudelo
{{penmiss}} Rodríguez
{{penmiss}} Goitía

|stadium=Ciudad de Caseros

|attendance=

|referee=Pablo Giménez

}}

{{footballbox collapsible

|date=February 26, 2020

|time=17:35

|team1=Aldosivi

|score=1–3

|report=https://www.copaargentina.org/es/partido/3315_Aldosivi-vs-Talleres-RE-.html

|team2= Talleres (RdE)

|goals1=Verón {{goal|90+4}}

|goals2=Sosa {{goal|38}}
Aranda {{goal|86||90+5}}

|attendance=

|referee=Jorge Broggi

}}

{{footballbox collapsible

|date=March 4, 2020

|time=21:30

|team1=Central Córdoba (SdE)

|score=0–1

|report=https://www.copaargentina.org/es/partido/3343_Central-Cordoba-SdE-vs-San-Telmo.html

|team2= San Telmo

|goals1=

|goals2=Ramírez Agudelo {{goal|90}}

|stadium=Padre Ernesto Martearena

|location=Salta, Pcia. de Salta

|attendance=

|referee=Jorge Baliño

}}

{{footballbox collapsible

|date=March 10, 2021

|time=19:20

|team1=Atlético Tucumán

|score=3–0

|report=https://www.copaargentina.org/es/partido/3332_Atletico-Tucuman-vs-Comunicaciones.html

|team2= Comunicaciones

|goals1=Carrera {{goal|46}}
Lotti {{goal|61}}
J. Toledo {{goal|88}}

|goals2=

|stadium=Presidente Perón

|location=Córdoba, Pcia. de Córdoba

|attendance=

|referee=Yael Falcón Pérez

}}

{{footballbox collapsible

|date=March 2, 2021

|time=22:15

|team1=Defensa y Justicia

|score=1–0

|report=https://www.copaargentina.org/es/partido/3327_Defensa-y-Justicia-vs-Estudiantes-BA-.html

|team2= Estudiantes (BA)

|goals1=Bou {{goal|40}}

|goals2=

|stadium=Alfredo Beranger

|attendance=

|referee=Jorge Broggi

}}

{{footballbox collapsible

|date=March 1, 2021

|time=21:30

|team1=San Martín (T)

|score=0–1

|report=https://www.copaargentina.org/es/partido/3324_San-Martin-T-vs-San-Martin-SJ-.html

|team2= San Martín (SJ)

|goals1=

|goals2=Diarte {{goal|84|o.g.}}

|stadium=Presidente Perón

|location=Córdoba, Pcia. de Córdoba

|attendance=

|referee=Jorge Baliño

}}

{{footballbox collapsible

|date=February 21, 2021

|time=17:10

|team1=Atlanta

|score=0–0

|report=https://www.copaargentina.org/es/partido/3335_Atlanta-vs-Villa-San-Carlos.html

|team2= Villa San Carlos

|goals1=

|goals2=

|penalties1=Colombini {{pengoal}}
Ochoa Giménez {{pengoal}}
Tecilla {{pengoal}}
Coronel {{penmiss}}
Cuenca {{penmiss}}

|penaltyscore=3–4

|penalties2={{pengoal}} Fernandes Silva
{{pengoal}} Alegre
{{pengoal}} Badell
{{pengoal}} Iberbia

|stadium=Ciudad de Caseros

|attendance=

|referee=Carlos Gariano

}}

{{footballbox collapsible

|date=January 14, 2021

|time=21:10

|team1=Colón

|score=1–0

|report=https://www.copaargentina.org/es/partido/3340_Colon-vs-Cipolletti.html

|team2= Cipolletti

|goals1=Aliendro {{goal|82}}

|goals2=

|stadium=Presbítero Bartolomé Grella

|location=Paraná, Pcia. de Entre Ríos

|attendance=

|referee=Carlos Gariano

}}

{{footballbox collapsible

|date=January 7, 2021

|time=18:00

|team1=Estudiantes (RC)

|score=1–0

|report=https://www.copaargentina.org/es/partido/3319_Estudiantes-RC-vs-Chaco-For-Ever.html

|team2= Chaco For Ever

|goals1=Ortigoza {{goal|90+3|pen.}}

|goals2=

|stadium=Nuevo Monumental

|location=Rafaela, Pcia. de Santa Fe

|attendance=

|referee=Silvio Trucco

}}

{{footballbox collapsible

|date=March 2, 2021

|time=20:10

|team1=Talleres (C)

|score=0–0

|report=https://www.copaargentina.org/es/partido/3320_Talleres-C-vs-Atletico-de-Rafaela.html

|team2= Atlético de Rafaela

|goals1=

|goals2=

|penalties1=Retegui {{pengoal}}
Pérez {{pengoal}}
Auzqui {{pengoal}}
Méndez {{pengoal}}
E. Díaz {{penmiss}}
Hincapié {{penmiss}}
M. Díaz {{penmiss}}
Navarro {{pengoal}}
Valoyes {{pengoal}}

|penaltyscore=6–5

|penalties2={{pengoal}} Bieler
{{pengoal}} Chimino
{{pengoal}} Giménez
{{pengoal}} González
{{penmiss}} Romero
{{penmiss}} Luna
{{penmiss}} Calderara
{{pengoal}} Sara
{{penmiss}} Albertengo

|stadium= Único de San Nicolás

|location=San Nicolás de los Arroyos, Pcia. de Buenos Aires

|attendance=

|referee=Mariano González

}}

{{footballbox collapsible

|date=March 5, 2020

|time=20:05

|team1=Unión

|score=1–1

|report=https://www.copaargentina.org/es/partido/3339_Union-SF-vs-Dock-Sud.html

|team2= Dock Sud

|goals1=Calderón {{goal|90+2}}

|goals2=Caruso {{goal|40}}

|penalties1=Troyansky {{pengoal}}
Cabrera {{pengoal}}
Cañete {{pengoal}}
Mazzola {{penmiss}}
Bou {{pengoal}}
Elías {{pengoal}}
Milo {{penmiss}}

|penaltyscore=5–6

|penalties2={{pengoal}} Kissner
{{pengoal}} Villalba
{{pengoal}} Tamborelli
{{pengoal}} Soria
{{penmiss}} Manes
{{pengoal}} Armoa
{{pengoal}} Adín

|stadium=Nuevo Monumental

|location=Rafaela, Pcia. de Santa Fe

|attendance=

|referee=Yael Falcón Pérez

}}

{{footballbox collapsible

|date=February 27, 2020

|time=20:05

|team1=Patronato

|score=1–1

|report=https://www.copaargentina.org/es/partido/3336_Patronato-vs-Instituto.html

|team2= Instituto

|goals1=Silveira {{goal|37}}

|goals2=Arce {{goal|60|pen.}}

|penalties1=Silveira {{pengoal}}
Díaz {{pengoal}}
Torres {{pengoal}}
Barreto {{pengoal}}
Abero {{pengoal}}

|penaltyscore=5–3

|penalties2={{pengoal}} Sills
{{pengoal}} Agüero
{{pengoal}} Silva
{{penmiss}} Erpen

|stadium=15 de Abril

|location=Santa Fe, Pcia. de Santa Fe

|attendance=

|referee=Carlos Córdoba

}}

{{footballbox collapsible

|date=December 30, 2020

|time=19:10

|team1=Godoy Cruz

|score=3–1

|report=https://www.copaargentina.org/es/partido/3323_Godoy-Cruz-vs-Justo-Jose-de-Urquiza.html

|team2= J. J. Urquiza

|goals1=Ferrari {{goal|33}}
Pizarro {{goal|58}}
Tesuri {{goal|84}}

|goals2=Bonacci {{goal|34}}

|attendance=

|referee=Diego Abal

}}

{{footballbox collapsible

|date=February 20, 2021

|time=17:10

|team1=Tigre

|score=1–1

|report=https://www.copaargentina.org/es/partido/3328_Tigre-vs-Alvarado.html

|team2= Alvarado

|goals1=Díaz {{goal|65}}

|goals2=Valiente {{goal|86}}

|penalties1=Magnín {{pengoal}}
Blondel {{pengoal}}
Prieto {{pengoal}}
Cavallaro {{pengoal}}
Cabrera {{pengoal}}

|penaltyscore=5–3

|penalties2={{penmiss}} Navarro
{{pengoal}} Ponce
{{pengoal}} Giacomini
{{pengoal}} Mantia

|stadium=Centenario Ciudad de Quilmes

|location=Quilmes, Pcia. de Buenos Aires

|attendance=

|referee=César Córdoba

}}

{{footballbox collapsible

|date=February 19, 2021The match, originally scheduled to be played on March 19, 2020 was postponed due to the COVID-19 pandemic

|time=21:30

|team1=Defensores de Belgrano

|score=4–2

|report=https://www.copaargentina.org/es/partido/3347_Defensores-de-Belgrano-vs-Almirante-Brown.html

|team2= Almirante Brown

|goals1=Lugones {{goal|3}}
López {{goal|53}}
Olivares {{goal|67}}
Aquilino {{goal|90+6}}

|goals2=D. García {{goal|23|pen.}}
Vera {{goal|61}}

|stadium=Ciudad de Caseros

|attendance=

|referee=Pablo Dóvalo

}}

{{footballbox collapsible

|date=March 10, 2020

|time=18:00

|team1=Platense

|score=0–1

|report=https://www.copaargentina.org/es/partido/3344_Platense-vs-Deportivo-Madryn.html

|team2= Deportivo Madryn

|goals1=

|goals2=Distaulo {{goal|43}}

|stadium=Ciudad de Caseros

|attendance=

|referee=Sebastián Zunino

}}

{{footballbox collapsible

|date=March 12, 2020Match suspended in the 20th minute due to rain. The original date was March 11, 2020. The remaining 70 minutes were played on March 12, 2020.

|time=17:00

|team1=Sarmiento (J)

|score=3–0

|report=https://www.copaargentina.org/es/partido/3316_Sarmiento-J-vs-Douglas-Haig.html

|team2= Douglas Haig

|goals1=Magnín {{goal|13}}
Pombo {{goal|73||83}}

|goals2=

|stadium=Centenario Ciudad de Quilmes

|location=Quilmes, Pcia. de Buenos Aires

|attendance=

|referee=Diego Ceballos

}}

=Round of 32=

This round had 32 qualified teams from the Round of 64. The round was played between 17 March and 4 August 2021, in a single knock-out match format. The 16 winning teams advanced to the Round of 16.

{{footballbox collapsible

|date=May 17, 2021

|time=17:10

|team1=Newell's Old Boys

|score=0–1

|report=https://www.copaargentina.org/es/partido/3369_Newell-s-vs-Sarmiento-J-.html

|team2= Sarmiento (J)

|goals1=

|goals2=Borasi {{goal|35}}

|stadium= Único de San Nicolás

|location=San Nicolás de los Arroyos, Pcia. de Buenos Aires

|attendance=

|referee=Pablo Echavarría

}}

{{footballbox collapsible

|date=May 19, 2021

|time=15:10

|team1=Talleres (RdE)

|score=0–4

|report=https://www.copaargentina.org/es/partido/3351_Talleres-RE-vs-Temperley.html

|team2= Temperley

|goals1=

|goals2=Vivanco {{goal|4}}
Baldunciel {{goal|51}}
Reinhart {{goal|77}}
Allione {{goal|89}}

|stadium=Ciudad de Caseros

|attendance=

|referee=Lucas Novelli Sanz

}}

{{footballbox collapsible

|date=April 21, 2021

|time=14:00

|team1=Huracán Las Heras

|score=1–4

|report=https://www.copaargentina.org/es/partido/3356_Huracan-Las-Heras-vs-Estudiantes-RC-.html

|team2= Estudiantes (RC)

|goals1=L. Agüero {{goal|83|pen.}}

|goals2=Ferreira {{goal|12|pen.|69}}
Hesar {{goal|43}}
D'Angelo {{goal|89}}

|stadium=Eva Perón

|location=Junín, Pcia. de Buenos Aires

|attendance=

|referee=Adrián Franklin

}}

{{footballbox collapsible

|date=April 7, 2021

|time=18:00

|team1=Talleres (C)

|score=1–1

|report=https://www.copaargentina.org/es/partido/3361_Talleres-C-vs-Velez.html

|team2= Vélez Sarsfield

|goals1=Santos {{goal|13}}

|goals2=Janson {{goal|90+3}}

|penalties1=Retegui {{pengoal}}
Lago {{penmiss}}
Guilherme Parede {{pengoal}}
Soñora {{pengoal}}

|penaltyscore=3–1

|penalties2={{penmiss}} Álvarez
{{penmiss}} Janson
{{pengoal}} Lucero
{{penmiss}} Galdames

|stadium=Florencio Sola

|attendance=

|referee=Yael Falcón Pérez

}}

{{footballbox collapsible

|date=May 13, 2021

|time=14:10

|team1=Boca Unidos

|score=0–2

|report=https://www.copaargentina.org/es/partido/3355_Boca-Unidos-vs-Godoy-Cruz.html

|team2= Godoy Cruz

|goals1=

|goals2=Bullaude {{goal|14}}
Ojeda {{goal|45+2}}

|stadium=El Gigante de Alberdi

|location= Córdoba, Pcia. de Córdoba

|attendance=

|referee=Jorge Broggi

}}

{{footballbox collapsible

|date=April 14, 2021

|time=21:10

|team1=San Martín (SJ)

|score=2–2

|report=https://www.copaargentina.org/es/partido/3363_San-Martin-SJ-vs-Racing-Club.html

|team2= Racing

|goals1=Giménez {{goal|80}}
Rescaldani {{goal|82}}

|goals2=Martínez {{goal|34}}
Copetti {{goal|63}}

|penalties1=Denis {{penmiss}}
Rivero {{penmiss}}
Prósperi {{pengoal}}

|penaltyscore=1–4

|penalties2={{pengoal}} Reniero
{{pengoal}} Martínez
{{pengoal}} Chancalay
{{pengoal}} Gutiérrez

|attendance=

|referee=Silvio Trucco

}}

{{footballbox collapsible

|date=March 25, 2021

|time=19:10

|team1=San Lorenzo

|score=0–2

|report=https://www.copaargentina.org/es/partido/3362_San-Lorenzo-vs-Defensa-y-Justicia.html

|team2= Defensa y Justicia

|goals1=

|goals2=Benítez {{goal|24}}
Merentiel {{goal|90+2}}

|stadium=Florencio Sola

|attendance=

|referee=Diego Abal

}}

{{footballbox collapsible

|date=August 4, 2021The match, originally scheduled to be played on April 14, 2021 was postponed due to the COVID-19 pandemic

|time=16:00

|team1=Tigre

|score=2–1

|report=https://www.copaargentina.org/es/partido/3365_Tigre-vs-Independiente.html

|team2= Independiente

|goals1=Magnín {{goal|32}}
Protti {{goal|68}}

|goals2=S. Romero {{goal|53}}

|stadium= Único de San Nicolás

|location=San Nicolás de los Arroyos, Pcia. de Buenos Aires

|attendance=

|referee=Fernando Echenique

}}

{{footballbox collapsible

|date=March 24, 2021

|time=20:10

|team1=Boca Juniors

|score=3–0

|report=https://www.copaargentina.org/es/partido/3360_Boca-vs-Defensores-de-Belgrano.html

|team2= Defensores de Belgrano

|goals1=Zárate {{goal|10|pen.|76|pen.}}
Mas {{goal|62}}

|goals2=

|stadium=Ciudad de La Plata

|attendance=

|referee=Mauro Vigliano

}}

{{footballbox collapsible

|date=April 7, 2021

|time=20:30

|team1=Atlético Tucumán

|score=1–2

|report=https://www.copaargentina.org/es/partido/3366_Atletico-Tucuman-vs-River.html

|team2= River Plate

|goals1=Heredia {{goal|64}}

|goals2=Girotti {{goal|11||21}}

|stadium=Ciudad de La Plata

|attendance=

|referee=Ariel Penel

}}

{{footballbox collapsible

|date=May 12, 2021

|time=14:10

|team1=Estudiantes (SL)

|score=1–2

|report=https://www.copaargentina.org/es/partido/3359_Estudiantes-SL-vs-Villa-San-Carlos.html

|team2= Villa San Carlos

|goals1=L. Quiroga {{goal|69}}

|goals2=Silva {{goal|54}}
Ruiz Martínez {{goal|84}}

|stadium=Coloso del Ruca Quimey

|location=Cutral Có, Pcia. de Neuquén

|attendance=

|referee=Juan Pafundi

}}

{{footballbox collapsible

|date=April 6, 2021

|time=21:10

|team1=Patronato

|score=2–2

|report=https://www.copaargentina.org/es/partido/3358_Patronato-vs-Lanus.html

|team2= Lanús

|goals1=Arias {{goal|69|pen.|81}}

|goals2=Esquivel {{goal|43}}
De la Vega {{goal|72}}

|penalties1=Sosa Sánchez {{pengoal}}
Torres {{pengoal}}
Franco {{pengoal}}
Palavecino {{pengoal}}
Marín {{pengoal}}

|penaltyscore=5–3

|penalties2={{penmiss}} De la Vega
{{pengoal}} Morales
{{pengoal}} A. Pérez
{{pengoal}} Orsini

|attendance=

|referee=Cristian Cernadas

}}

{{footballbox collapsible

|date=March 23, 2021

|time=22:10

|team1=Gimnasia y Esgrima (LP)

|score=5–0

|report=https://www.copaargentina.org/es/partido/3352_Gimnasia-La-Plata-vs-Dock-Sud.html

|team2= Dock Sud

|goals1=Carbonero {{goal|1}}
Pérez García {{goal|29}}
Cecchini {{goal|42}}
Contín {{goal|50}}
Ramírez {{goal|57}}

|goals2=

|stadium=Alfredo Beranger

|attendance=

|referee=Ariel Suárez

}}

{{footballbox collapsible

|date=March 17, 2021

|time=17:15

|team1=Colón

|score=0–1

|report=https://www.copaargentina.org/es/partido/3353_Colon-vs-Argentinos-Juniors.html

|team2= Argentinos Juniors

|goals1=

|goals2=Ávalos {{goal|16}}

|stadium=Único de San Nicolás

|location=San Nicolás de los Arroyos, Pcia. de Buenos Aires

|attendance=

|referee=Sebastián Mastrángelo

}}

{{footballbox collapsible

|date=March 17, 2021

|time=15:05

|team1=Laferrere

|score=0–2

|report=https://www.copaargentina.org/es/partido/3354_Deportivo-Laferrere-vs-San-Telmo.html

|team2= San Telmo

|goals1=

|goals2=Ramírez {{goal|64||73}}

|stadium=Alfredo Beranger

|attendance=

|referee=Héctor Paletta

}}

{{footballbox collapsible

|date=April 28, 2021

|time=15:10

|team1=Deportivo Madryn

|score=0–1

|report=https://www.copaargentina.org/es/partido/3367_Deportivo-Madryn-vs-Banfield.html

|team2= Banfield

|goals1=

|goals2=Pons {{goal|66}}

|stadium=Alfredo Beranger

|attendance=

|referee=Pablo Echavarría

}}

=Round of 16=

This round had the 16 qualified teams from the Round of 32. The round was played between 13 July and 22 September 2021, in a single knock-out match format. The 8 winning teams advanced to the Quarterfinals.

{{footballbox collapsible

|date=July 20, 2021

|time=15:05

|team1=Sarmiento (J)

|score=0–1

|report=https://www.copaargentina.org/es/partido/3375_Sarmiento-J-vs-Temperley.html

|team2= Temperley

|goals1=

|goals2=Pumpido {{goal|67}}

|stadium=Único de San Nicolás

|location=San Nicolás de los Arroyos, Pcia. de Buenos Aires

|attendance=

|referee=Carlos Gariano

}}

{{footballbox collapsible

|date=August 11, 2021

|time=21:30

|team1=Estudiantes (RC)

|score=1–1

|report=https://www.copaargentina.org/es/partido/3372_Estudiantes-RC-vs-Talleres-C-.html

|team2= Talleres (C)

|goals1=Talpone {{goal|51}}

|goals2=Santos {{goal|86}}

|penalties1=Bottino {{pengoal}}
Padilla {{pengoal}}
Formica {{pengoal}}
Hermann {{pengoal}}
Pardo {{pengoal}}
Dutari {{penmiss}}

|penaltyscore=5–6

|penalties2={{pengoal}} Retegui
{{pengoal}} Fértoli
{{pengoal}} Santos
{{pengoal}} Auzqui
{{pengoal}} E. Díaz
{{pengoal}} Valoyes

|stadium=Marcelo Bielsa

|location=Rosario, Pcia. de Santa Fe

|attendance=

|referee=Facundo Tello

}}

{{footballbox collapsible

|date=September 22, 2021

|time=18:10

|team1=Godoy Cruz

|score=3–3

|report=https://www.copaargentina.org/es/partido/3374_Godoy-Cruz-vs-Racing-Club.html

|team2= Racing

|goals1=Bullaude {{goal|12}}
Burgoa {{goal|15}}
M. Ramírez {{goal|77}}

|goals2=L. López {{goal|43}}
Copetti {{goal|61}}
Correa {{goal|89}}

|penalties1=González {{pengoal}}
Ojeda {{pengoal}}
Acevedo {{pengoal}}
M. Ramírez {{pengoal}}
Bullaude {{pengoal}}

|penaltyscore=5–4

|penalties2={{pengoal}} Lovera
{{pengoal}} F. Domínguez
{{pengoal}} Chancalay
{{pengoal}} Alcaraz
{{penmiss}} Copetti

|stadium=Mario Alberto Kempes

|location=Córdoba, Pcia. de Córdoba

|attendance=

|referee=Fernando Rapallini

}}

{{footballbox collapsible

|date=September 8, 2021

|time=21:10

|team1=Defensa y Justicia

|score=0–0

|report=https://www.copaargentina.org/es/partido/3376_Defensa-y-Justicia-vs-Tigre.html

|team2= Tigre

|goals1=

|goals2=

|penalties1=Frías {{penmiss}}
Benítez {{pengoal}}
Merentiel {{pengoal}}
Barrios {{pengoal}}
Bou {{pengoal}}
Gutiérrez {{penmiss}}
Pizzini {{penmiss}}

|penaltyscore=4–5

|penalties2={{pengoal}} Magnín
{{penmiss}} González Metilli
{{pengoal}} Marinelli
{{pengoal}} Prieto
{{pengoal}} Céliz
{{penmiss}} Cabrera
{{pengoal}} Menossi

|stadium=Juan Carmelo Zerillo

|attendance=

|referee=Lucas Comesaña

}}

{{footballbox collapsible

|date=August 4, 2021

|time=19:00

|team1=Boca Juniors

|score=0–0

|report=https://www.copaargentina.org/es/partido/3370_Boca-vs-River.html

|team2= River Plate

|goals1=

|goals2=

|penalties1=Rojo {{pengoal}}
Ramírez {{pengoal}}
Pavón {{pengoal}}
Izquierdoz {{pengoal}}

|penaltyscore=4–1

|penalties2={{penmiss}} Álvarez
{{penmiss}} Romero
{{pengoal}} Martínez

|stadium=Ciudad de La Plata

|attendance=

|referee=Patricio Loustau

}}

{{footballbox collapsible

|date=July 13, 2021

|time=15:35

|team1=Villa San Carlos

|score=0–1

|report=https://www.copaargentina.org/es/partido/3373_Villa-San-Carlos-vs-Patronato.html

|team2= Patronato

|goals1=

|goals2=Delgadillo {{goal|73}}

|stadium=Eva Perón

|location=Junín, Pcia. de Buenos Aires

|attendance=

|referee=Adrián Franklin

}}

{{footballbox collapsible

|date=August 18, 2021

|time=18:00

|team1=Gimnasia y Esgrima (LP)

|score=2–3

|report=https://www.copaargentina.org/es/partido/3379_Gimnasia-La-Plata-vs-Argentinos-Juniors.html

|team2= Argentinos Juniors

|goals1=Ramírez {{goal|30}}
Rodríguez {{goal|89|pen.}}

|goals2=Carabajal {{goal|61|pen.}}
Reniero {{goal|67}}
Guiffrey {{goal|77|o.g.}}

|stadium=Florencio Sola

|attendance=

|referee=Ariel Penel

}}

{{footballbox collapsible

|date=July 14, 2021

|time=15:35

|team1=San Telmo

|score=1–0

|report=https://www.copaargentina.org/es/partido/3371_San-Telmo-vs-Banfield.html

|team2= Banfield

|goals1=Amilivia {{goal|81}}

|goals2=

|stadium=Alfredo Beranger