2021 Coca-Cola 600

File:Lowesmotorspeedway.jpg, the track where the race was held.]]

The race was held at Charlotte Motor Speedway, located in Concord, North Carolina. The speedway complex includes a {{Convert|1.5|mi|km|adj=on}} quad-oval track that was utilized for the race, as well as a dragstrip and a dirt track. The speedway was built in 1959 by Bruton Smith and is considered the home track for NASCAR with many race teams based in the Charlotte metropolitan area. The track is owned and operated by Speedway Motorsports Inc. (SMI) with Marcus G. Smith serving as track president.

Similar to the Daytona 500, which was a four-stage race (with the first stage being the qualifying heat race), the Coca-Cola 600 is a four-stage race, with this the only race where all four stages are in the main race itself. All four stages are scheduled to consist of 100 laps. The race is official after the second stage.

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• (R) denotes rookie driver.
• (i) denotes driver who are ineligible for series driver points.

Austin Dillon was the fastest in the practice session with a time of 29.845 seconds and a speed of {{Convert|180.935|mph|km/h|abbr=on}}.{{cite web|last=Utter|first=Jim|title=Austin Dillon and Chevrolet lead Coke 600 practice|url=https://us.motorsport.com/nascar-cup/news/austin-dillon-coke-600-practice/6517373/|website=Motorsport.com|publisher=Motorsport Network|access-date=May 28, 2021|location=Charlotte, North Carolina|date=May 28, 2021}}

Kyle Larson scored the pole for the race with a time of 29.953 and a speed of {{Convert|180.282|mph|km/h|abbr=on}}.{{cite web|last=Utter|first=Jim|title=Kyle Larson wins Coke 600 pole as Chevys dominate|url=https://us.motorsport.com/nascar-cup/news/kyle-larson-coke-600-pole/6517975/|website=Motorsport.com|publisher=Motorsport Network|access-date=May 29, 2021|location=Charlotte, North Carolina|date=May 29, 2021}}

Stage One

Laps: 100

Stage Two

Laps: 100

Stage Three

Laps: 100

Stage Four

Laps: 100

• Lead changes: 23 among 13 different drivers
• Cautions/Laps: 4 for 26
• Red flags: 0
• Time of race: 3 hours, 58 minutes and 45 seconds
• Average speed: {{convert|150.785|mph|km/h}}

Fox Sports televised the race in the United States for the 21st consecutive year. Mike Joy was the lap-by-lap announcer, while three-time Coca-Cola 600 winner, Jeff Gordon and 2012 Fall Charlotte winner Clint Bowyer were the color commentators. Jamie Little, Regan Smith and Vince Welch reported from pit lane during the race. Larry McReynolds provided insight from the Fox Sports studio in Charlotte.

Radio coverage of the race was broadcast by the Performance Racing Network (PRN), and was simulcasted on Sirius XM NASCAR Radio. Doug Rice and Mark Garrow called the race in the booth when the field raced through the quad-oval. Rob Albright called the race from a billboard in turn 2 when the field was racing through turns 1 and 2 and halfway down the backstretch. Pat Patterson called the race from a billboard outside of turn 3 when the field raced through the other half of the backstretch and through turns 3 and 4. Brad Gillie, Brett McMillan and Wendy Venturini were the pit reporters during the broadcast.

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;Drivers' Championship standings

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;Manufacturers' Championship standings

• Note: Only the first 16 positions are included for the driver standings.
• . – Driver has clinched a position in the NASCAR Cup Series playoffs.

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Coca-Cola 600

Coca-Cola 600

Coca-Cola 600

Category:NASCAR races at Charlotte Motor Speedway