2021 Copa Paraguay

64 teams took part, with the competition keeping the same format used in the previous edition.{{cite web|url=https://www.hoy.com.py/deportes/mas-equipos-en-copa-paraguay-para-el-2019|title=Más equipos en Copa Paraguay para el 2019|publisher=HOY|date=11 August 2018|accessdate=19 May 2019}} The competition is played as a single-elimination tournament, with all teams directly qualifying for the first round, where they were drawn into 32 single-legged ties. Ties in all rounds will be played as a single game, with a penalty shootout deciding the winner in case of a draw.

64 teams competed in this edition of the competition: the 10 Primera División and 18 División Intermedia teams, as well as 11 from the Primera B, 8 from the Primera C, and the 17 champions from each department of Paraguay representing the UFI.

All of the 10 Primera División teams took part in the competition:

{{Div col|colwidth=18em}}

• 12 de Octubre (I)
• Cerro Porteño
• Guaireña
• Guaraní
• Libertad
• Nacional
• Olimpia
• River Plate
• Sol de América
• Sportivo Luqueño

{{div col end}}

All of the 18 División Intermedia teams took part:

{{Div col|colwidth=18em}}

• 2 de Mayo
• 3 de Febrero (CDE)
• Atyrá
• Deportivo Capiatá
• Deportivo Santaní
• Fernando de la Mora
• Fulgencio Yegros
• General Caballero (JLM)
• General Díaz
• Guaraní (T)
• Independiente (CG)
• Resistencia
• Rubio Ñu
• San Lorenzo
• Sportivo Ameliano
• Sportivo Iteño
• Sportivo Trinidense
• Tacuary

{{div col end}}

The 9 teams ranked from 2nd to 10th place in the 2019 Primera B season and the top two in the 2019 Primera C season qualified:

{{Div col|colwidth=18em}}

• 3 de Febrero (RB)
• 12 de Octubre (SD)
• 24 de Setiembre (VP)
• 29 de Setiembre
• Cristóbal Colón (JAS)
• Cristóbal Colón (Ñ)
• Olimpia (I)
• Presidente Hayes
• Recoleta
• Sportivo Limpeño
• Tembetary

{{div col end}}

Teams ranked from 3rd to 10th place in the previous Primera C season qualified:

{{Div col|colwidth=18em}}

• Atlético Juventud
• Benjamín Aceval
• Deportivo Pinozá
• General Caballero (CG)
• Humaitá
• Oriental
• Silvio Pettirossi
• Sport Colonial

{{div col end}}

The champions from each of the 17 departments of Paraguay qualified for the competition:

{{Div col|colwidth=18em}}

• Teniente Rojas (Concepción)
• 12 de Octubre (VR) (San Pedro)
• 5 de Octubre (Cordillera)
• Karai Chivé (Guairá)
• Atlético Mil Palos (Caaguazú)
• Coronel Martínez (Caazapá)
• 22 de Setiembre (Itapúa)
• 24 de Junio (Misiones)
• Deportivo La Colmena (Paraguarí)
• Deportivo Primavera (Alto Paraná)
• Ytororó (Central)
• 1° de Marzo FBC (Ñeembucú)
• Mariscal Estigarribia (Amambay)
• Sport Pacobá (Canindeyú)
• Independiente (N) (Presidente Hayes)
• Atlético Trébol (Boquerón)
• Sport Sastreño (Alto Paraguay)

{{div col end}}

The draw for the round of 64 was held on 9 March 2020 and the matches were scheduled to be played from 14 April 2020 onwards.{{cite web|url=http://www.tigosports.com.py/copa-paraguay/edicion-2020-sorteo-32avos-de-final|title=La Copa Paraguay 2020 conoce sus cruces|publisher=Tigo Sports|date=9 March 2020|accessdate=12 March 2020}} On 15 July 2021, the APF confirmed that the round of 64 games would be played from 27 July to 26 August 2021.

{{football box collapsible

|date= {{Start date|2021|7|27|df=y}}

|time= 17:00

|team1= Cristóbal Colón (Ñ) (3)

|team2= Guaraní (1)

|score= 1–1

|report= https://www.apf.org.py/n/cristobal-colon-avanzo-a-la-siguiente-fase

|goals1=

• Villalba {{goal|84|pen.}}

|goals2=

• Oviedo {{goal|73}}

|penaltyscore= 4–2

|penalties1=

• Villalba {{pengoal}}
• Cáceres {{pengoal}}
• Verón {{pengoal}}
• Ruiz {{pengoal}}

|penalties2=

• {{penmiss}} González
• {{pengoal}} Villalva
• {{penmiss}} Colmán
• {{pengoal}} Oviedo

|stadium= Feliciano Cáceres

|location= Luque

|attendance=

|referee= Sergio Melgarejo

}}

{{football box collapsible

|date= {{Start date|2021|7|27|df=y}}

|time= 19:30

|team1= 3 de Febrero (RB) (3)

|team2= Sol de América (1)

|score= 0–6

|report= https://www.apf.org.py/n/se-mete-a-la-proxima-ronda

|goals1=

|goals2=

• Viera {{goal|5||26}}
• Da Costa {{goal|54}}
• Mencia {{goal|72}}
• Valle {{goal|79|o.g.}}
• Castro {{goal|84}}

|stadium= Feliciano Cáceres

|location= Luque

|attendance=

|referee= Julio Ojeda

}}

{{football box collapsible

|date= {{Start date|2021|7|28|df=y}}

|time= 13:00

|team1= Recoleta (3)

|team2= General Caballero (JLM) (2)

|score= 1–2

|report= https://www.apf.org.py/n/general-caballero-de-mallorquin-avanza-a-la-siguiente-etapa

|goals1=

• Espínola {{goal|82}}

|goals2=

• De Souza {{goal|28||67}}

|stadium= Ka'arendy

|location= Juan León Mallorquín

|attendance=

|referee= Edgar Barrios

}}

{{football box collapsible

|date= {{Start date|2021|7|28|df=y}}

|time= 15:00

|team1= Deportivo Primavera (4)

|team2= Olimpia (1)

|score= 0–6

|report= https://www.apf.org.py/n/olimpia-paso-a-los-16vos-de-final

|goals1=

|goals2=

• Mendieta {{goal|2}}
• Camacho {{goal|41}}
• Peralta {{goal|44||61}}
• Sosa {{goal|52|pen.}}
• Estigarribia {{goal|74}}

|stadium= Ka'arendy

|location= Juan León Mallorquín

|attendance=

|referee= Derlis Benítez

}}

{{football box collapsible

|date= {{Start date|2021|7|29|df=y}}

|time= 15:00

|team1= Benjamín Aceval (4)

|team2= Cerro Porteño (1)

|score= 0–2

|report= https://www.apf.org.py/n/el-ciclon-paso-a-la-siguiente-ronda

|goals1=

|goals2=

• Báez {{goal|6}}
• Acosta {{goal|78}}

|stadium= Isidro Roussillón

|location= Villa Hayes

|attendance=

|referee= César Rolón

}}

{{football box collapsible

|date= {{Start date|2021|7|29|df=y}}

|time= 17:30

|team1= Atlético Trébol (4)

|team2= Fernando de la Mora (2)

|score= 0–17

|report= https://www.apf.org.py/n/el-rojo-se-anoto-en-la-proxima-etapa

|goals1=

|goals2=

• Alonso {{goal|17||45||71||78||85}}
• Quintana {{goal|19||24||35}}
• Bareiro {{goal|47||62}}
• Sanabria {{goal|48||76}}
• Amarilla {{goal|65}}
• Araujo {{goal|67||75||80}}
• Esteche {{goal|87}}

|stadium= Isidro Roussillón

|location= Villa Hayes

|attendance=

|referee= Víctor Ruiz

}}

{{football box collapsible

|date= {{Start date|2021|8|3|df=y}}

|time= 13:00

|team1= Sport Pacobá (4)

|team2= Tacuary (2)

|score= 0–0

|report= https://www.apf.org.py/n/tacuary-avanza-a-la-siguiente-ronda

|goals1=

|goals2=

|penaltyscore= 2–3

|penalties1=

• González {{pengoal}}
• Rodríguez {{penmiss}}
• Rodas {{pengoal}}
• Caballero {{penmiss}}
• Moral {{penmiss}}

|penalties2=

• {{penmiss}} Aranda
• {{pengoal}} Bernal
• {{pengoal}} Giménez
• {{penmiss}} Cantero
• {{pengoal}} Salcedo

|stadium= Juan José Vázquez

|location= San Estanislao

|attendance=

|referee= Ángel Brítez

}}

{{football box collapsible

|date= {{Start date|2021|8|3|df=y}}

|time= 15:00

|team1= Teniente Rojas (4)

|team2= Deportivo Santaní (2)

|score= 0–5

|report= https://www.apf.org.py/n/deportivo-santani-se-mete-a-los-16vos-de-final

|goals1=

|goals2=

• Sequeira {{goal|55||67}}
• A. Benítez {{goal|62|o.g.}}
• C. Villalba {{goal|74}}
• O. Villalba {{goal|80}}

|stadium= Juan José Vázquez

|location= San Estanislao

|attendance=

|referee= Zulma Quiñónez

}}

{{football box collapsible

|date= {{Start date|2021|8|4|df=y}}

|time= 17:00

|team1= Ytororó (4)

|team2= Sportivo Luqueño (1)

|score= 0–3

|report= https://www.apf.org.py/n/el-auriazul-se-anota-en-los-16vos-de-final

|goals1=

|goals2=

• Bazán {{goal|20|pen.|38}}
• González {{goal|41}}

|stadium= Feliciano Cáceres

|location= Luque

|attendance=

|referee= Jorge Ruiz Díaz

}}

{{football box collapsible

|date= {{Start date|2021|8|4|df=y}}

|time= 19:30

|team1= 29 de Setiembre (3)

|team2= Libertad (1)

|score= 0–5

|report= https://www.apf.org.py/n/el-gumarelo-paso-a-la-siguiente-ronda

|goals1=

|goals2=

• Melgarejo {{goal|34}}
• Franco {{goal|35}}
• Ferreira {{goal|50||66||90+2}}

|stadium= Feliciano Cáceres

|location= Luque

|attendance=

|referee= Marcos Galeano

}}

{{football box collapsible

|date= {{Start date|2021|8|5|df=y}}

|time= 15:00

|team1= Sport Sastreño (4)

|team2= General Caballero (CG) (4)

|score= 1–0

|report= https://www.apf.org.py/n/sport-sastreno-paso-a-siguiente-ronda

|goals1=

• Alarcón {{goal|62|pen.}}

|goals2=

|stadium= Isidro Roussillón

|location= Villa Hayes

|attendance=

|referee= Christian Aquino

}}

{{football box collapsible

|date= {{Start date|2021|8|5|df=y}}

|time= 17:30

|team1= Independiente (N) (4)

|team2= 3 de Febrero (CDE) (2)

|score= 0–2

|report= https://www.apf.org.py/n/atletico-3-de-febrero-a-los-16vos-de-final

|goals1=

|goals2=

• Caballero {{goal|51}}
• Garcete {{goal|90+4}}

|stadium= Isidro Roussillón

|location= Villa Hayes

|attendance=

|referee= Álvaro Giménez

}}

{{football box collapsible

|date= {{Start date|2021|8|10|df=y}}

|time= 13:00

|team1= Sport Colonial (4)

|team2= Sportivo Ameliano (2)

|score= 1–2

|report= https://www.apf.org.py/n/sportivo-ameliano-avanza-a-la-siguiente-fase

|goals1=

• Alfonso {{goal|56|o.g.}}

|goals2=

• Caballero {{goal|17}}
• Arce {{goal|82}}

|stadium= Roque Battilana

|location= Asunción

|attendance=

|referee= Dionicio Cristaldo

}}

{{football box collapsible

|date= {{Start date|2021|8|10|df=y}}

|time= 15:00

|team1= Silvio Pettirossi (4)

|team2= Resistencia (2)

|score= 0–3

|report= https://www.apf.org.py/n/resistencia-clasifica-a-16vos-de-final

|goals1=

|goals2=

• Benítez {{goal|38}}
• Ruiz Díaz {{goal|47}}
• Die. Martínez {{goal|90+1}}

|stadium= Roque Battilana

|location= Asunción

|attendance=

|referee= Christian Aquino

}}

{{football box collapsible

|date= {{Start date|2021|8|11|df=y}}

|time= 17:00

|team1= Presidente Hayes (3)

|team2= Fulgencio Yegros (2)

|score= 1–1

|report= https://www.apf.org.py/n/presidente-hayes-se-anota-en-16vos

|goals1=

• Núñez {{goal|8}}

|goals2=

• Escobar {{goal|29}}

|penaltyscore= 3–1

|penalties1=

• Núñez {{pengoal}}
• Cuesta {{penmiss}}
• R. Ramírez {{penmiss}}
• M. Ramírez {{pengoal}}
• Enciso {{pengoal}}

|penalties2=

• {{penmiss}} Zarza
• {{penmiss}} Romero
• {{penmiss}} Curtido
• {{pengoal}} Acuña

|stadium= Luis Alfonso Giagni

|location= Villa Elisa

|attendance=

|referee= Marco Franco

}}

{{football box collapsible

|date= {{Start date|2021|8|11|df=y}}

|time= 19:30

|team1= 12 de Octubre (SD) (3)

|team2= Rubio Ñu (2)

|score= 1–2

|report= https://www.apf.org.py/n/rubio-nu-avanza-a-la-siguiente-fase

|goals1=

• Bernal {{goal|88|o.g.}}

|goals2=

• Aquino {{goal|23}}
• Mereles {{goal|63}}

|stadium= Luis Alfonso Giagni

|location= Villa Elisa

|attendance=

|referee= Juan Franco

}}

{{football box collapsible

|date= {{Start date|2021|8|12|df=y}}

|time= 17:00

|team1= Oriental (4)

|team2= Deportivo Capiatá (2)

|score= 1–1

|report= https://www.apf.org.py/n/oriental-se-suma-a-los-16avos-de-final

|goals1=

• Cabrera {{goal|53}}

|goals2=

• Báez {{goal|83}}

|penaltyscore= 4–3

|penalties1=

• Martínez {{penmiss}}
• Jara {{pengoal}}
• Soler {{pengoal}}
• Speratti {{pengoal}}
• D. González {{pengoal}}

|penalties2=

• {{pengoal}} Pérez
• {{penmiss}} Bracho
• {{pengoal}} Aquino
• {{penmiss}} Saldívar
• {{pengoal}} Báez

|stadium= Arsenio Erico

|location= Asunción

|attendance=

|referee= Sixto Mercado

}}

{{football box collapsible

|date= {{Start date|2021|8|12|df=y}}

|time= 19:30

|team1= Humaitá (4)

|team2= Independiente (CG) (2)

|score= 2–2

|report= https://www.apf.org.py/n/se-anota-en-la-siguiente-fase

|goals1=

• Arboleda {{goal|63}}
• Cardozo {{goal|75}}

|goals2=

• Orué {{goal|13}}
• Garay {{goal|45+1}}

|penaltyscore= 5–6

|penalties1=

• Ortellado {{pengoal}}
• Arrúa {{pengoal}}
• Ramírez {{pengoal}}
• González {{pengoal}}
• Ibarra {{pengoal}}
• Cardozo {{penmiss}}
• Britez {{penmiss}}

|penalties2=

• {{pengoal}} Asta
• {{pengoal}} Benítez
• {{pengoal}} Villagra
• {{pengoal}} Fernández
• {{pengoal}} Garay
• {{penmiss}} Doldán
• {{pengoal}} Sanabria

|stadium= Arsenio Erico

|location= Asunción

|attendance=

|referee= Héctor Bernal

}}

{{football box collapsible

|date= {{Start date|2021|8|16|df=y}}

|time= 13:00

|team1= Mariscal Estigarribia (4)

|team2= San Lorenzo (2)

|score= 5–1

|report= https://www.apf.org.py/n/mariscal-estigarribia-avanza-a-la-siguiente-fase

|goals1=

• Fernández {{goal|11||67|pen.|73}}
• Rojas {{goal|23}}
• Florenciano {{goal|47}}

|goals2=

• Maciel {{goal|28}}

|stadium= Río Parapití

|location= Pedro Juan Caballero

|attendance=

|referee= Víctor Ruiz

}}

{{football box collapsible

|date= {{Start date|2021|8|16|df=y}}

|time= 15:00

|team1= 24 de Junio (4)

|team2= 2 de Mayo (2)

|score= 0–1

|report= https://www.apf.org.py/n/2-de-mayo-paso-a-los-16vos-de-final

|goals1=

|goals2=

• Cáceres {{goal|39}}

|stadium= Río Parapití

|location= Pedro Juan Caballero

|attendance=

|referee= Arthur Afara

}}

{{football box collapsible

|date= {{Start date|2021|8|17|df=y}}

|time= 17:00

|team1= Sportivo Limpeño (3)

|team2= Tembetary (3)

|score= 0–0

|report= https://www.apf.org.py/n/tembetary-con-boleto-a-los-16avos-de-final

|goals1=

|goals2=

|penaltyscore= 3–4

|penalties1=

• Molinas {{penmiss}}
• F. Galeano {{pengoal}}
• A. González {{pengoal}}
• Jara {{pengoal}}
• Paniagua {{penmiss}}

|penalties2=

• {{pengoal}} Cáceres
• {{pengoal}} Ju. Roa
• {{pengoal}} Villamayor
• {{pengoal}} González

|stadium= Martín Torres

|location= Asunción

|attendance=

|referee= Julio Ojeda

}}

{{football box collapsible

|date= {{Start date|2021|8|17|df=y}}

|time= 19:30

|team1= 5 de Octubre (4)

|team2= General Díaz (2)

|score= 1–0

|report= https://www.apf.org.py/n/5-de-octubre-pasa-a-los-16vos-de-final

|goals1=

• Delvalle {{goal|13|pen.}}

|goals2=

|stadium= Martín Torres

|location= Asunción

|attendance=

|referee= Alberto Candia

}}

{{football box collapsible

|date= {{Start date|2021|8|18|df=y}}

|time= 17:00

|team1= Deportivo La Colmena (4)

|team2= Sportivo Iteño (2)

|score= 0–4

|report= https://www.apf.org.py/n/sportivo-iteno-se-anota-en-16vos-de-final

|goals1=

|goals2=

• Escobar {{goal|6|pen.}}
• Guerreño {{goal|30||51}}
• Barreto {{goal|49}}

|stadium= Parque del Guairá

|location= Villarrica

|attendance=

|referee= Arcenio Mereles

}}

{{football box collapsible

|date= {{Start date|2021|8|18|df=y}}

|time= 19:30

|team1= Coronel Martínez (4)

|team2= River Plate (1)

|score= 0–2

|report= https://www.apf.org.py/n/river-plate-esta-en-la-siguiente-ronda

|goals1=

|goals2=

• Gallardo {{goal|53}}
• Alvarenga {{goal|87|o.g.}}

|stadium= Parque del Guairá

|location= Villarrica

|attendance=

|referee= Gedidías Zacarías

}}

{{football box collapsible

|date= {{Start date|2021|8|19|df=y}}

|time= 13:00

|team1= 22 de Setiembre (3)

|team2= Atyrá (2)

|score= 2–1

|report= https://www.apf.org.py/n/22-de-setiembre-se-anota-a-los-16avos-de-final

|goals1=

• Cristaldo {{goal|74}}
• Ortiz {{goal|88}}

|goals2=

• Lázaro {{goal|34}}

|stadium= Los Fundadores

|location= Trinidad

|attendance=

|referee= Sixto Mercado

}}

{{football box collapsible

|date= {{Start date|2021|8|19|df=y}}

|time= 15:00

|team1= Olimpia (I) (3)

|team2= Guaraní (T) (2)

|score= 0–0

|report= https://www.apf.org.py/n/guarani-de-trinidad-a-la-siguiente-ronda

|goals1=

|goals2=

|penaltyscore= 6–7

|penalties1=

• Ramos {{pengoal}}
• Recalde {{pengoal}}
• R. Gómez {{pengoal}}
• Bourdier {{penmiss}}
• Valdez {{pengoal}}
• Caputo {{pengoal}}
• Orué {{penmiss}}
• Báez {{pengoal}}
• Miranda {{penmiss}}

|penalties2=

• {{pengoal}} Portillo
• {{pengoal}} M. González
• {{pengoal}} Chaparro
• {{penmiss}} Gómez
• {{pengoal}} Lezcano
• {{pengoal}} Dávalos
• {{penmiss}} Britto
• {{pengoal}} Ortiz
• {{pengoal}} J. González

|stadium= Los Fundadores

|location= Trinidad

|attendance=

|referee= Héctor Bernal

}}

{{football box collapsible

|date= {{Start date|2021|8|24|df=y}}

|time= 17:00

|team1= Karai Chivé (4)

|team2= 12 de Octubre (VR) (4)

|score= 1–1

|report= https://www.apf.org.py/n/karai-chive-se-anota-en-16vos

|goals1=

• Á. Velázquez {{goal|67|o.g.}}

|goals2=

• Giménez {{goal|62|pen.}}

|penaltyscore= 4–2

|penalties1=

• Duarte {{pengoal}}
• Gómez {{pengoal}}
• Villalba {{penmiss}}
• Lezcano {{pengoal}}
• García {{pengoal}}

|penalties2=

• {{pengoal}} Mujica
• {{pengoal}} Giménez
• {{penmiss}} Oporto
• {{penmiss}} Á. Torres

|stadium= Parque del Guairá

|location= Villarrica

|attendance=

|referee= Ángel Brítez

}}

{{football box collapsible

|date= {{Start date|2021|8|24|df=y}}

|time= 19:30

|team1= 24 de Setiembre (VP) (3)

|team2= Guaireña (1)

|score= 0–3

|report= https://www.apf.org.py/n/guairena-fc-avanza-de-fase

|goals1=

|goals2=

• Duarte {{goal|52||56|pen.}}
• Cáceres {{goal|68}}

|stadium= Parque del Guairá

|location= Villarrica

|attendance=

|referee= Héctor Bernal

}}

{{football box collapsible

|date= {{Start date|2021|8|25|df=y}}

|time= 13:00

|team1= Atlético Juventud (4)

|team2= Sportivo Trinidense (2)

|score= 2–0

|report= https://www.apf.org.py/n/juventud-paso-a-la-proxima-etapa

|goals1=

• González {{goal|52}}
• Arrúa {{goal|89|pen.}}

|goals2=

|stadium= La Arboleda

|location= Asunción

|attendance=

|referee= Víctor Ruiz

}}

{{football box collapsible

|date= {{Start date|2021|8|25|df=y}}

|time= 15:15

|team1= 1° de Marzo FBC (4)

|team2= Nacional (1)

|score= 0–0

|report= https://www.apf.org.py/n/1-0-de-marzo-se-suma-a-16vos

|goals1=

|goals2=

|penaltyscore= 3–0

|penalties1=

• Cabañas {{pengoal}}
• Amarilla {{pengoal}}
• Enciso {{pengoal}}

|penalties2=

• {{penmiss}} Prieto
• {{penmiss}} Fleitas
• {{penmiss}} Colmán

|stadium= La Arboleda

|location= Asunción

|attendance=

|referee= César Rolón

}}

{{football box collapsible

|date= {{Start date|2021|8|26|df=y}}

|time= 17:00

|team1= Cristóbal Colón (JAS) (3)

|team2= Deportivo Pinozá (4)

|score= 4–0

|report= https://www.apf.org.py/n/colon-de-jas-clasificado-a-la-siguiente-ronda

|goals1=

• Chaparro {{goal|24}}
• Centurión {{goal|35}}
• Ricardo {{goal|74||79}}

|goals2=

|stadium= Luis Alberto Salinas

|location= Itauguá

|attendance=

|referee= Rodrigo Serafini

}}

{{football box collapsible

|date= {{Start date|2021|8|26|df=y}}

|time= 19:30

|team1= Atlético Mil Palos (4)

|team2= 12 de Octubre (I) (1)

|score= 1–6

|report= https://www.apf.org.py/n/12-de-octubre-de-itaugua-se-suma-a-los-clasificados

|goals1=

• Araújo {{goal|70}}

|goals2=

• Bobadilla {{goal|12||90+1}}
• Ortiz {{goal|34}}
• Brítez {{goal|44||50}}
• Álvarez {{goal|82}}

|stadium= Luis Alberto Salinas

|location= Itauguá

|attendance=

|referee= Derlis Benítez

}}

The schedule for the round of 32 was confirmed by the APF on 26 August 2021. Matches in this round were played from 1 to 23 September 2021.{{cite web |title=Así se jugarán los 16vos. de final |url=https://www.apf.org.py/n/asi-se-jugaran-los-16vos-de-final |publisher=APF |access-date=27 August 2021 |language=es |date=26 August 2021}}

{{football box collapsible

|date= {{Start date|2021|9|1|df=y}}

|time= 17:00

|team1= 5 de Octubre (4)

|team2= Deportivo Santaní (2)

|score= 0–3

|report= https://www.apf.org.py/n/el-primer-adelantado

|goals1=

|goals2=

• Leiva {{goal|37}}
• Meza {{goal|81||83}}

|stadium= Luis Alfonso Giagni

|location= Villa Elisa

|attendance=

|referee= Víctor Ruiz

}}

{{football box collapsible

|date= {{Start date|2021|9|1|df=y}}

|time= 19:30

|team1= Atlético Juventud (4)

|team2= Libertad (1)

|score= 0–2

|report= https://www.apf.org.py/n/con-boletos-a-los-octavos-de-final

|goals1=

|goals2=

• Espinoza {{goal|42}}
• Franco {{goal|45}}

|stadium= Luis Alfonso Giagni

|location= Villa Elisa

|attendance=

|referee= José Armoa

}}

{{football box collapsible

|date= {{Start date|2021|9|13|df=y}}

|time= 17:00

|team1= Tembetary (3)

|team2= Presidente Hayes (3)

|score= 2–1

|report= https://www.apf.org.py/n/tembetary-avanza-a-los-octavos-de-final

|goals1=

• Maciel {{goal|52||90+6}}

|goals2=

• Núñez {{goal|63}}

|stadium= Erico Galeano

|location= Capiatá

|attendance=

|referee= César Rolón

}}

{{football box collapsible

|date= {{Start date|2021|9|13|df=y}}

|time= 19:30

|team1= Sportivo Iteño (2)

|team2= Mariscal Estigarribia (4)

|score= 1–1

|report= https://www.apf.org.py/n/iteno-se-metio-a-la-siguiente-ronda

|goals1=

• Díaz {{goal|43}}

|goals2=

• Pérez {{goal|57}}

|penaltyscore= 4–3

|penalties1=

• Gauto {{pengoal}}
• Barreto {{pengoal}}
• Loncharich {{pengoal}}
• Díaz {{pengoal}}

|penalties2=

• {{pengoal}} Soares
• {{pengoal}} Blanco
• {{penmiss}} Mendoza
• {{pengoal}} Villamayor
• {{penmiss}} Fernández

|stadium= Erico Galeano

|location= Capiatá

|attendance=

|referee= Luis Urunaga

}}

{{football box collapsible

|date= {{Start date|2021|9|14|df=y}}

|time= 17:15

|team1= Guaraní (T) (2)

|team2= Sport Sastreño (4)

|score= 3–0

|report= https://apf.org.py/n/entre-los-16-mejores-de-la-copa-de-todos-1

|goals1=

• Dietze {{goal|45+1||50}}
• Dávalos {{goal|88}}

|goals2=

|stadium= Isidro Roussillón

|location= Villa Hayes

|attendance=

|referee= Marco Franco

}}

{{football box collapsible

|date= {{Start date|2021|9|15|df=y}}

|time= 14:45

|team1= Cerro Porteño (1)

|team2= General Caballero (JLM) (2)

|score= 1–1

|report= https://www.apf.org.py/n/cerro-porteno-avanza-a-octavos

|goals1=

• Fariña {{goal|29}}

|goals2=

• Arce {{goal|44}}

|penaltyscore= 4–1

|penalties1=

• Muñoz {{pengoal}}
• Giménez {{pengoal}}
• Bobadilla {{pengoal}}
• Ovelar {{pengoal}}

|penalties2=

• {{penmiss}} Mareco
• {{penmiss}} Acuña
• {{pengoal}} Lezcano

|stadium= Ka'arendy

|location= Juan León Mallorquín

|attendance=

|referee= César Herebia

}}

{{football box collapsible

|date= {{Start date|2021|9|15|df=y}}

|time= 17:15

|team1= Resistencia (2)

|team2= Cristóbal Colón (Ñ) (3)

|score= 8–4

|report= https://www.apf.org.py/n/resistencia-se-mete-a-la-siguiente-fase

|goals1=

• Arévalos {{goal|6||45+1||58||90+2}}
• Blanco {{goal|54}}
• J. Cáceres {{goal|74|pen.|89}}
• Báez {{goal|90}}

|goals2=

• Ó. Cáceres {{goal|32}}
• Roa {{goal|60||79||82}}

|stadium= Arsenio Erico

|location= Asunción

|attendance=

|referee= Julio Quintana

}}

{{football box collapsible

|date= {{Start date|2021|9|15|df=y}}

|time= 19:45

|team1= Cristóbal Colón (JAS) (3)

|team2= Olimpia (1)

|score= 2–3

|report= https://www.apf.org.py/n/olimpia-paso-a-la-proxima-etapa-de-la-copa-de-todos

|goals1=

• Miranda {{goal|36}}
• Santa Cruz {{goal|72|o.g.}}

|goals2=

• Recalde {{goal|1}}
• Santa Cruz {{goal|17}}
• Sosa {{goal|41}}

|stadium= Arsenio Erico

|location= Asunción

|attendance=

|referee= David Ojeda

}}

{{football box collapsible

|date= {{Start date|2021|9|16|df=y}}

|time= 17:00

|team1= Guaireña (1)

|team2= Oriental (4)

|score= 2–1

|report= https://www.apf.org.py/n/guairena-fc-avanza-a-los-octavos-de-final

|goals1=

• Florenciañez {{goal|40}}
• Alborno {{goal|90+3}}

|goals2=

• Alvarenga {{goal|58}}

|stadium= Antonio Aranda

|location= Ciudad del Este

|attendance=

|referee= Gedidías Zacarías

}}

{{football box collapsible

|date= {{Start date|2021|9|16|df=y}}

|time= 19:30

|team1= 3 de Febrero (CDE) (2)

|team2= 12 de Octubre (I) (1)

|score= 0–1

|report= https://www.apf.org.py/n/el-12-de-octubre-a-la-siguiente-fase

|goals1=

|goals2=

• D. Mendieta {{goal|30}}

|stadium= Antonio Aranda

|location= Ciudad del Este

|attendance=

|referee= Blas Romero

}}

{{football box collapsible

|date= {{Start date|2021|9|21|df=y}}

|time= 17:00

|team1= Karai Chivé (4)

|team2= River Plate (1)

|score= 2–4

|report= https://www.apf.org.py/n/river-plate-se-anota-en-los-octavos-de-final

|goals1=

• González {{goal|62}}
• Acosta {{goal|79}}

|goals2=

• Sosa {{goal|45+1}}
• Zeballos {{goal|46||67}}
• Caballero {{goal|84|pen.}}

|stadium= Martín Torres

|location= Asunción

|attendance=

|referee= Christian Aquino

}}

{{football box collapsible

|date= {{Start date|2021|9|21|df=y}}

|time= 19:30

|team1= Sportivo Ameliano (2)

|team2= Independiente (CG) (2)

|score= 2–1

|report= https://www.apf.org.py/n/ameliano-avanza-a-la-siguiente-etapa

|goals1=

• Merlo {{goal|45}}
• Olmedo {{goal|74|pen.}}

|goals2=

• Riveros {{goal|40}}

|stadium= Martín Torres

|location= Asunción

|attendance=

|referee= Julio Quintana

}}

{{football box collapsible

|date= {{Start date|2021|9|22|df=y}}

|time= 16:15

|team1= Sportivo Luqueño (1)

|team2= Fernando de la Mora (2)

|score= 3–2

|report= https://apf.org.py/n/luqueno-se-mete-a-octavos-de-final

|goals1=

• Parra {{goal|40}}
• González Ozuna {{goal|58}}
• Pérez {{goal|74}}

|goals2=

• Giménez {{goal|17}}
• Acosta {{goal|60}}

|stadium= River Plate

|location= Asunción

|attendance=

|referee= Sergio Melgarejo

}}

{{football box collapsible

|date= {{Start date|2021|9|22|df=y}}

|time= 20:15

|team1= Rubio Ñu (2)

|team2= Sol de América (1)

|score= 3–4

|report= https://apf.org.py/n/sol-de-america-se-inscribe-en-la-siguiente-ronda

|goals1=

• Espínola {{goal|11}}
• Coronel {{goal|18}}
• Oviedo {{goal|35}}

|goals2=

• Viera {{goal|22|pen.|70}}
• Báez {{goal|36}}
• Jiménez {{goal|64}}

|stadium= River Plate

|location= Asunción

|attendance=

|referee= Blas Romero

}}

{{football box collapsible

|date= {{Start date|2021|9|23|df=y}}

|time= 15:30

|team1= 2 de Mayo (2)

|team2= 22 de Setiembre (3)

|score= 3–0

|report= https://apf.org.py/n/el-gallo-norteno-se-metio-a-octavos-de-final

|goals1=

• Aranda {{goal|73}}
• Cáceres {{goal|79||90+4}}

|goals2=

|stadium= Feliciano Cáceres

|location= Luque

|attendance=

|referee= Sixto Mercado

}}

{{football box collapsible

|date= {{Start date|2021|9|23|df=y}}

|time= 18:00

|team1= 1° de Marzo FBC (4)

|team2= Tacuary (2)

|score= 1–4

|report= https://apf.org.py/n/tacuary-con-el-ultimo-boleto-a-octavos

|goals1=

• R. Amarilla {{goal|18}}

|goals2=

• Rodríguez {{goal|25}}
• Giménez {{goal|36}}
• V. Matta {{goal|72|pen.}}
• A. Amarilla {{goal|87}}

|stadium= Feliciano Cáceres

|location= Luque

|attendance=

|referee= David Ojeda

}}

{{16TeamBracket|legs=1/1/1/1

| team-width = 150|nowrap=y|seeds=no

| RD1 = Round of 16

| RD2 = Quarter-finals

| RD3 = Semi-finals

| RD4 = Final

| RD4b = Third place play-off

| RD1-team01=Cerro Porteño

| RD1-score01=0

| RD1-team02=Sol de América

| RD1-score02=2

| RD1-team03=2 de Mayo

| RD1-score03=1 (4)

| RD1-team04=Deportivo Santaní {{pso}}

| RD1-score04=1 (5)

| RD1-team05=River Plate

| RD1-score05=0

| RD1-team06=Tembetary

| RD1-score06=1

| RD1-team07=Tacuary {{pso}}

| RD1-score07=0 (4)

| RD1-team08=Sportivo Iteño

| RD1-score08=0 (3)

| RD1-team09=Olimpia

| RD1-score09=2

| RD1-team10=Resistencia

| RD1-score10=1

| RD1-team11=Sportivo Ameliano

| RD1-score11=0 (4)

| RD1-team12=Guaireña {{pso}}

| RD1-score12=0 (5)

| RD1-team13=Libertad

| RD1-score13=5

| RD1-team14=Guaraní (T)

| RD1-score14=0

| RD1-team15=Sportivo Luqueño {{pso}}

| RD1-score15=1 (4)

| RD1-team16=12 de Octubre (I)

| RD1-score16=1 (3)

| RD2-team01=Sol de América

| RD2-score01=1

| RD2-team02=Deportivo Santaní

| RD2-score02=0

| RD2-team03=Tembetary {{pso}}

| RD2-score03=1 (4)

| RD2-team04=Tacuary

| RD2-score04=1 (2)

| RD2-team05=Olimpia

| RD2-score05=2

| RD2-team06= Guaireña

| RD2-score06=0

| RD2-team07=Libertad

| RD2-score07=2

| RD2-team08=Sportivo Luqueño

| RD2-score08=0

| RD3-team01=Sol de América {{pso}}

| RD3-score01=0 (5)

| RD3-team02=Tembetary

| RD3-score02=0 (4)

| RD3-team03=Olimpia {{pso}}

| RD3-score03=1 (5)

| RD3-team04=Libertad

| RD3-score04=1 (4)

| RD4-team01=Sol de América

| RD4-score01=2 (1)

| RD4-team02=Olimpia {{pso}}

| RD4-score02=2 (3)

| RD4b-team01=Tembetary

| RD4b-score01=0

| RD4b-team02=Libertad

| RD4b-score02=2

}}

The schedule for the round of 16 was announced by the APF on 28 September 2021. Matches in this round were played from 5 to 20 October 2021.{{cite web |title=Calendario de los octavos de final de la Copa Paraguay |url=https://www.apf.org.py/n/calendario-de-los-octavos-de-final-de-la-copa-paraguay |publisher=APF |access-date=29 September 2021 |language=es |date=28 September 2021}}

{{football box collapsible

|date= {{Start date|2021|10|5|df=y}}

|time= 17:30

|team1= Sportivo Luqueño (1)

|team2= 12 de Octubre (I) (1)

|score= 1–1

|report= https://www.apf.org.py/n/luqueno-avanza-a-cuartos

|goals1=

• Pérez {{goal|61}}

|goals2=

• Doldán {{goal|80}}

|penaltyscore= 4–3

|penalties1=

• Borja {{pengoal}}
• Castro {{pengoal}}
• Palau {{pengoal}}
• Ortiz {{pengoal}}

|penalties2=

• {{penmiss}} Aguilar
• {{pengoal}} González
• {{pengoal}} Paredes
• {{pengoal}} Núñez
• {{penmiss}} D. Mendieta

|stadium= Luis Alfonso Giagni

|location= Villa Elisa

|attendance=

|referee= César Rolón

}}

{{football box collapsible

|date= {{Start date|2021|10|5|df=y}}

|time= 20:00

|team1= Olimpia (1)

|team2= Resistencia (2)

|score= 2–1

|report= https://apf.org.py/n/olimpia-a-la-siguiente-fase

|goals1=

• D. González {{goal|36||69}}

|goals2=

• Olveira {{goal|46|o.g.}}

|stadium= Luis Alfonso Giagni

|location= Villa Elisa

|attendance=

|referee= Gedidías Zacarías

}}

{{football box collapsible

|date= {{Start date|2021|10|6|df=y}}

|time= 17:30

|team1= River Plate (1)

|team2= Tembetary (3)

|score= 0–1

|report= https://www.apf.org.py/n/el-rojiverde-paso-a-cuartos

|goals1=

|goals2=

• Mereles {{goal|69}}

|stadium= Arsenio Erico

|location= Asunción

|attendance=

|referee= Nelson Palma

}}

{{football box collapsible

|date= {{Start date|2021|10|6|df=y}}

|time= 20:00

|team1= Cerro Porteño (1)

|team2= Sol de América (1)

|score= 0–2

|report= https://www.apf.org.py/n/el-danzarin-se-inscribe-en-la-siguiente-etapa

|goals1=

|goals2=

• Viera {{goal|53}}
• Cazal {{goal|81}}

|stadium= Arsenio Erico

|location= Asunción

|attendance=

|referee= César Herebia

}}

{{football box collapsible

|date= {{Start date|2021|10|13|df=y}}

|time= 16:00

|team1= Tacuary (2)

|team2= Sportivo Iteño (2)

|score= 0–0

|report= https://www.apf.org.py/n/tacuary-se-instala-en-cuartos

|goals1=

|goals2=

|penaltyscore= 4–3

|penalties1=

• V. Matta {{pengoal}}
• Velázquez {{pengoal}}
• Bernal {{penmiss}}
• M. Matta {{pengoal}}
• Domínguez {{pengoal}}

|penalties2=

• {{pengoal}} Gauto
• {{penmiss}} Escobar
• {{penmiss}} Díaz
• {{pengoal}} O. Benítez
• {{pengoal}} E. Benítez

|stadium= Juan José Vázquez

|location= San Estanislao

|attendance=

|referee= Aldo Quiñónez

}}

{{football box collapsible

|date= {{Start date|2021|10|13|df=y}}

|time= 18:15

|team1= 2 de Mayo (2)

|team2= Deportivo Santaní (2)

|score= 1–1

|report= https://apf.org.py/n/santani-a-la-siguiente-fase

|goals1=

• Cáceres {{goal|65}}

|goals2=

• V. Villalba {{goal|47}}

|penaltyscore= 4–5

|penalties1=

• Jara {{pengoal}}
• Oviedo {{pengoal}}
• Paredes {{penmiss}}
• Cáceres {{pengoal}}
• Leguizamón {{pengoal}}

|penalties2=

• {{pengoal}} Álvarez
• {{pengoal}} V. Villalba
• {{pengoal}} Sequeira
• {{pengoal}} Coronel
• {{pengoal}} Ovando

|stadium= Juan José Vázquez

|location= San Estanislao

|attendance=

|referee= Nelson Palma

}}

{{football box collapsible

|date= {{Start date|2021|10|20|df=y}}

|time= 17:30

|team1= Libertad (1)

|team2= Guaraní (T) (2)

|score= 5–0

|report= https://www.apf.org.py/n/el-gumarelo-avanza-a-cuartos

|goals1=

• Ferreira {{goal|9}}
• Enciso {{goal|56||83}}
• Bogarín {{goal|65}}
• Cardozo {{goal|85}}

|goals2=

|stadium= Luis Alfonso Giagni

|location= Villa Elisa

|attendance=

|referee= César Rolón

}}

{{football box collapsible

|date= {{Start date|2021|10|20|df=y}}

|time= 20:00

|team1= Sportivo Ameliano (2)

|team2= Guaireña (1)

|score= 0–0

|report= https://www.apf.org.py/n/guairena-fc-paso-a-la-siguiente-etapa

|goals1=

|goals2=

|penaltyscore= 4–5

|penalties1=

• Báez {{pengoal}}
• Duré {{pengoal}}
• Rojas {{pengoal}}
• Merlo {{penmiss}}
• Cabrera {{penmiss}}
• Gaitán {{pengoal}}
• Riquelme {{penmiss}}

|penalties2=

• {{penmiss}} Candia
• {{pengoal}} Miño
• {{pengoal}} Cantero
• {{pengoal}} Brizuela
• {{penmiss}} Florenciañez
• {{pengoal}} Fr. Parra
• {{pengoal}} Ruiz

|stadium= Luis Alfonso Giagni

|location= Villa Elisa

|attendance=

|referee= Derlis Benítez

}}

The schedule for the quarter-finals was announced by the APF on 22 October 2021. Matches in this round were played from 3 to 10 November 2021.{{cite web |title=APF programa los cuartos de final de la Copa Paraguay |url=https://d10.ultimahora.com/apf-programa-los-cuartos-final-la-copa-paraguay-n2967881.html |publisher=D10 |access-date=22 October 2021 |language=es |date=22 October 2021}}{{cite web |title=Modificación en un juego de los cuartos de final |url=https://apf.org.py/n/modificacion-en-un-juego-de-los-cuartos-de-final |publisher=APF |language=es |date=2 November 2021 |access-date=2 November 2021}}

{{football box collapsible

|date= {{Start date|2021|11|3|df=y}}

|time= 17:45

|team1= Libertad (1)

|team2= Sportivo Luqueño (1)

|score= 2–0

|report= https://www.apf.org.py/n/libertad-es-el-primer-semifinalista

|goals1=

• Enciso {{goal|60}}
• Melgarejo {{goal|87}}

|goals2=

|stadium= Luis Alfonso Giagni

|location= Villa Elisa

|attendance=

|referee= César Rolón

}}

{{football box collapsible

|date= {{Start date|2021|11|3|df=y}}

|time= 20:15

|team1= Tembetary (3)

|team2= Tacuary (2)

|score= 1–1

|report= https://apf.org.py/n/tembetary-esta-entre-los-cuatro-mejores

|goals1=

• Maciel {{goal|49}}

|goals2=

• Salcedo {{goal|65}}

|penaltyscore= 4–2

|penalties1=

• Cáceres {{pengoal}}
• Fernández {{pengoal}}
• Mazacote {{pengoal}}
• Olmedo {{penmiss}}
• Maciel {{pengoal}}

|penalties2=

• {{penmiss}} Domínguez
• {{penmiss}} Bareiro
• {{pengoal}} M. Matta
• {{pengoal}} Aguilar

|stadium= Luis Alfonso Giagni

|location= Villa Elisa

|attendance=

|referee= Gedidías Zacarías

}}

{{football box collapsible

|date= {{Start date|2021|11|4|df=y}}

|time= 17:45

|team1= Olimpia (1)

|team2= Guaireña (1)

|score= 2–0

|report= https://www.apf.org.py/n/olimpia-tercer-semifinalista-de-la-copa-de-todos

|goals1=

• D. González {{goal|12}}
• Salcedo {{goal|57}}

|goals2=

|stadium= Feliciano Cáceres

|location= Luque

|attendance=

|referee= Nelson Palma

}}

{{football box collapsible

|date= {{Start date|2021|11|10|df=y}}

|time= 19:30

|team1= Sol de América (1)

|team2= Deportivo Santaní (2)

|score= 1–0

|report= https://www.apf.org.py/n/sol-el-ultimo-semifinalista

|goals1=

• Ayala {{goal|27}}

|goals2=

|stadium= Feliciano Cáceres

|location= Luque

|attendance=

|referee= Aldo Quiñónez

}}

The schedule for the semi-finals was announced by the APF on 7 November 2021. Both matches were played on 14 November 2021 at Estadio Defensores del Chaco in Asunción.{{cite web |title=Semifinales de Copa Paraguay, en medio de las Eliminatorias y en el Defensores |url=https://versus.lanacion.com.py/versus/2021/11/08/semifinales-de-copa-paraguay-en-medio-de-las-eliminatorias-y-en-el-defensores/ |publisher=Versus |access-date=9 November 2021 |language=es |date=8 November 2021}}

{{football box collapsible

|date= {{Start date|2021|11|14|df=y}}

|time= 18:15

|team1= Olimpia (1)

|team2= Libertad (1)

|score= 1–1

|report= https://www.apf.org.py/n/olimpia-es-el-primer-finalista-de-la-copa-paraguay

|goals1=

• D. González {{goal|3}}

|goals2=

• Melgarejo {{goal|35}}

|penaltyscore= 5–4

|penalties1=

• Recalde {{pengoal}}
• Quintana {{pengoal}}
• Ortiz {{pengoal}}
• W. González {{pengoal}}
• D. González {{pengoal}}

|penalties2=

• {{penmiss}} Vangioni
• {{pengoal}} Bocanegra
• {{pengoal}} Melgarejo
• {{pengoal}} Espinoza
• {{pengoal}} Cardozo

|stadium= Defensores del Chaco

|location= Asunción

|attendance=

|referee= Carlos Benítez

}}

{{football box collapsible

|date= {{Start date|2021|11|14|df=y}}

|time= 20:30

|team1= Sol de América (1)

|team2= Tembetary (3)

|score= 0–0

|report= https://www.apf.org.py/n/sol-jugara-la-final-de-la-copa-de-todos

|goals1=

|goals2=

|penaltyscore= 5–4

|penalties1=

• Viera {{pengoal}}
• Godoy {{pengoal}}
• Leal {{penmiss}}
• Rojas {{pengoal}}
• De La Cruz {{pengoal}}
• Leguizamón {{pengoal}}

|penalties2=

• {{penmiss}} Cáceres
• {{pengoal}} Fernández
• {{pengoal}} Mazacote
• {{pengoal}} Ortiz
• {{pengoal}} Maciel
• {{penmiss}} Ju. Roa

|stadium= Defensores del Chaco

|location= Asunción

|attendance=

|referee= Juan Gabriel Benítez

}}

{{football box

|date= {{Start date|2021|11|30|df=y}}

|time= 19:00

|team1= Tembetary (3)

|team2= Libertad (1)

|score= 0–2

|report= https://www.apf.org.py/n/libertad-se-quedo-con-el-tercer-puesto

|goals1=

|goals2=

• Enciso {{goal|30}}
• Melgarejo {{goal|63}}

|stadium= Estadio Luis Alfonso Giagni

|location= Villa Elisa

|attendance=

|referee= David Ojeda

}}

{{football box

|date= {{Start date|2021|12|1|df=y}}

|time= 19:00

|team1= Sol de América (1)

|team2= Olimpia (1)

|score= 2–2

|report= https://www.apf.org.py/n/olimpia-campeon-de-la-copa-paraguay

|goals1=

• Toledo {{goal|4||43}}

|goals2=

• Salcedo {{goal|23}}
• D. González {{goal|86|pen.}}

|penaltyscore= 1–3

|penalties1=

• Da Silva {{pengoal}}
• Godoy {{penmiss}}
• Rojas {{penmiss}}
• Ozuna {{penmiss}}

|penalties2=

• {{pengoal}} Recalde
• {{pengoal}} Ortiz
• {{pengoal}} Torres

|stadium= Estadio Defensores del Chaco

|location= Asunción

|attendance=

|referee= José Méndez

}}

{{reflist}}

• [https://www.apf.org.py/noticias/categoria/copa-paraguay Copa Paraguay] on the official website of the Paraguayan Football Association {{in lang|es}}
• [https://int.soccerway.com/national/paraguay/copa-paraguay/2021/ Copa Paraguay 2021], Soccerway.com

{{Football in Paraguay}}

{{2021 in South American football (CONMEBOL)}}

Copa Paraguay

Copa Paraguay

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