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• Emperor Constans II marries Fausta.

• April 30 – Chindasuinth, a Gothic warlord (already 79 years old), commences a rebellion and deposes King Tulga in Toledo, Spain. He is proclaimed king by the Visigothic nobility and anointed by the bishops. Tulga is tonsured and sent out to live his days in a monastery.
• Radulf, a Frankish aristocrat, revolts against King Sigebert III of Austrasia and defeats his army, taking the title of rex or king of Thuringia.{{cite book |last=Reuter |first=Timothy |author-link=Timothy Reuter |date=1991 |page=55 |title=Germany in the Early Middle Ages 800–1056 |location=New York |publisher=Longman |isbn=0-582-08156-4}}

• August 5 – Battle of Maserfield: King Penda of Mercia defeats and kills King Oswald of Northumbria, age 38, at Oswestry (West Midlands). He commands a united British and Mercian force, which includes the Welsh army of Kings Cadafael Cadomedd of Gwynedd and Cynddylan of Pengwern. The Mercians become dominant in the English Midlands.
• Oswiu succeeds his half-brother Oswald as king of Bernicia. He strengthens his position by marrying Eanflæd, daughter of King Edwin of Northumbria, then in exile in the Kingdom of Kent.{{sfn|Bede Book III|loc=[http://www.fordham.edu/halsall/basis/bede-book3.html Chapter XV]}} This marriage takes place between 642 and 644.

• Battle of Nahāvand: The Rashidun army (30,000 men) under Sa`d ibn Abi Waqqas defeats the Persians at Nahāvand (modern Iran). The Persian cavalry, full of confidence, mounts an ill-prepared attack. The Arabs retreat to a safe area, where they outmanoeuvre and destroy the Persians in a narrow mountain valley.

• Battle of Dongola: 'Amr ibn al-'As sends an Arab expedition of 20,000 horsemen, under his cousin Uqba ibn Nafi, to Makuria (Southern Egypt). The Nubians strike hard against the Muslims near Dongola with hit-and-run attacks. The Arab incursions into Nubia are temporarily halted.

• Emperor Taizong of the Tang dynasty issues a decree throughout China, that increases the punishment for men who deliberately inflict injuries upon themselves (most commonly breaking their own legs) in order to avoid military conscription. This decree is an effort to eradicate this practice that has grown as a trend since the time of the rebellion against the Sui dynasty.
• Taizong supports a revolt by Turkic tribes against the rebellious Tu-lu Qaghan of the Western Turkic Khaganate.
• Empress Kōgyoku ascends to the throne of Japan, after her husband (and uncle) Emperor Jomei's death in 641.
• Winter – Yeon Gaesomun seizes power over Goguryeo (Korea), and places King Bojang on the throne.

• The earliest surviving dated Arabic-language papyrus (PERF 558), found in Heracleopolis (Egypt), and the earliest known Arabic text with diacritical marks is written.

• Arabs begin construction of the Mosque of Amr at Cairo, the first mosque built in Egypt and in all of Africa.

• October 12 – Pope John IV dies after a 2-year reign. He is succeeded by a Jerusalem-born cleric of Greek descent, Theodore I, as the 73rd pope of Rome.
• A monastic settlement is founded in Hampshire (England) which later becomes Winchester Cathedral.

• Ceolfrith, Anglo-Saxon abbot (approximate date)
• Hasan al-Basri, Arab theologian (d. 728)
• Julian, archbishop of Toledo (d. 690)
• Máel Ruba, Irish abbot (d. 722)
• Mujahid ibn Jabr, Muslim scholar (or 645)

• March 21 – Cyrus of Alexandria, Patriarch of Alexandria and governor of Egypt
• August 5 or 641 – Oswald, king of Northumbria
• October 12 – Pope John IV
• Emma, Anglo-Saxon queen
• Eowa, king of Mercia (English Midlands)
• Domnall Brecc, king of Dál Riata{{cite book |editor1-last=Lynch |editor1-first=Michael |page=5 |title=The Oxford companion to Scottish history |date=February 24, 2011 |publisher=Oxford University Press |isbn=978-0-19-969305-4}}{{full citation needed|date=July 2021|reason=missing publication date for the version actually used here}}
• Domnall mac Áedo, high king of Ireland
• Flaochad, Mayor of the Palace (Burgundy)
• Heraklonas, Byzantine emperor (approximate date)
• Khalid ibn al-Walid, Arab general (b. 592)
• Mardanshah, Persian general
• Nanthild, Frankish queen
• Pulakeshin II, king of Chalukya (India)
• Willibad, patrician (of duke) of Burgundy
• Yeongnyu, king of Goguryeo (Korea)
• Yuwen Shiji, chancellor of the Tang dynasty

{{Reflist}}

{{refbegin}}

• {{cite web |last=Bede |author-link=Bede |title=Book III |work=Ecclesiastical History of the English People |publisher=Internet History Sourcebooks Project |url=http://www.fordham.edu/halsall/basis/bede-book3.html |ref={{harvid|Bede Book III}}}}

{{refend}}

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