ABCF2

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This protein is a member of the GCN20 subfamily. Alternative splicing of this gene results in multiple transcript variants.

ABCF2 acts as a suppressor of the volume-sensitive outwardly rectifying Cl channel (CLCN3).{{cite journal | vauthors = Ando-Akatsuka Y, Shimizu T, Numata T, Okada Y | title = Involvements of the ABC protein ABCF2 and α-actinin-4 in regulation of cell volume and anion channels in human epithelial cells | journal = Journal of Cellular Physiology | volume = 227 | issue = 10 | pages = 3498–510 | year = 2012 | pmid = 22252987 | doi = 10.1002/jcp.24050 | s2cid = 22139132 }}

• ATP-binding cassette transporter

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• {{cite journal | vauthors = Klein I, Sarkadi B, Váradi A | title = An inventory of the human ABC proteins | journal = Biochimica et Biophysica Acta (BBA) - Biomembranes | volume = 1461 | issue = 2 | pages = 237–62 | date = December 1999 | pmid = 10581359 | doi = 10.1016/s0005-2736(99)00161-3 | doi-access = free }}
• {{cite journal | vauthors = Dean M, Rzhetsky A, Allikmets R | title = The human ATP-binding cassette (ABC) transporter superfamily | journal = Genome Research | volume = 11 | issue = 7 | pages = 1156–66 | date = July 2001 | pmid = 11435397 | doi = 10.1101/gr.184901 | s2cid = 9528197 | doi-access = free }}
• {{cite journal | vauthors = Hogue DL, Liu L, Ling V | title = Identification and characterization of a mammalian mitochondrial ATP-binding cassette membrane protein | journal = Journal of Molecular Biology | volume = 285 | issue = 1 | pages = 379–89 | date = January 1999 | pmid = 9878413 | doi = 10.1006/jmbi.1998.2259 }}
• {{cite journal | vauthors = Zhang F, Hogue DL, Liu L, Fisher CL, Hui D, Childs S, Ling V | title = M-ABC2, a new human mitochondrial ATP-binding cassette membrane protein | journal = FEBS Letters | volume = 478 | issue = 1–2 | pages = 89–94 | date = July 2000 | pmid = 10922475 | doi = 10.1016/S0014-5793(00)01823-8 | s2cid = 41556343 | doi-access = free }}
• {{cite journal | vauthors = Ye Z, Connor JR | title = cDNA cloning by amplification of circularized first strand cDNAs reveals non-IRE-regulated iron-responsive mRNAs | journal = Biochemical and Biophysical Research Communications | volume = 275 | issue = 1 | pages = 223–7 | date = August 2000 | pmid = 10944468 | doi = 10.1006/bbrc.2000.3282 }}
• {{cite journal | vauthors = Stanchi F, Bertocco E, Toppo S, Dioguardi R, Simionati B, Cannata N, Zimbello R, Lanfranchi G, Valle G | title = Characterization of 16 novel human genes showing high similarity to yeast sequences | journal = Yeast | volume = 18 | issue = 1 | pages = 69–80 | date = January 2001 | pmid = 11124703 | doi = 10.1002/1097-0061(200101)18:1<69::AID-YEA647>3.0.CO;2-H | s2cid = 21397515 | doi-access = free }}
• {{cite journal | vauthors = Tsuda H, Ito YM, Ohashi Y, Wong KK, Hashiguchi Y, Welch WR, Berkowitz RS, Birrer MJ, Mok SC | title = Identification of overexpression and amplification of ABCF2 in clear cell ovarian adenocarcinomas by cDNA microarray analyses | journal = Clinical Cancer Research | volume = 11 | issue = 19 Pt 1 | pages = 6880–8 | date = October 2005 | pmid = 16203778 | doi = 10.1158/1078-0432.CCR-05-0751 | s2cid = 27248404 | doi-access = }}
• {{cite journal | vauthors = Nishimura S, Tsuda H, Ito K, Jobo T, Yaegashi N, Inoue T, Sudo T, Berkowitz RS, Mok SC | title = Differential expression of ABCF2 protein among different histologic types of epithelial ovarian cancer and in clear cell adenocarcinomas of different organs | journal = Human Pathology | volume = 38 | issue = 1 | pages = 134–9 | date = January 2007 | pmid = 16996567 | doi = 10.1016/j.humpath.2006.06.026 }}

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• {{MeshName|ABCF2+protein,+human}}
• {{UCSC genome browser|ABCF2}}
• {{UCSC gene details|ABCF2}}

{{NLM content}}

{{ABC transporters}}

{{DEFAULTSORT:Abcf2}}

Category:ATP-binding cassette transporters

Category:Genes on human chromosome 7

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