ABI gene family member 3

This gene encodes a member of an adaptor protein family. Members of this family encode proteins containing a homeobox homology domain, proline rich region and Src-homology 3 (SH3) domain. The encoded protein inhibits ectopic metastasis of tumor cells as well as cell migration. This may be accomplished through interaction with p21-activated kinases.

• ABI1
• ABI2
• ABI3BP

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• {{UCSC gene info|ABI3}}

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• {{cite journal | vauthors=Ichigotani Y, Fujii K, Hamaguchi M, Matsuda S |title=In search of a function for the E3B1/Abi2/Argbp1/NESH family (Review). |journal=Int. J. Mol. Med. |volume=9 |issue= 6 |pages= 591–5 |year= 2002 |pmid= 12011975 |doi= 10.3892/ijmm.9.6.591}}
• {{cite journal | vauthors=Miyazaki K, Matsuda S, Ichigotani Y |title=Isolation and characterization of a novel human gene (NESH) which encodes a putative signaling molecule similar to e3B1 protein |journal=Biochim. Biophys. Acta |volume=1493 |issue= 1–2 |pages= 237–41 |year= 2000 |pmid= 10978530 |doi= 10.1016/s0167-4781(00)00158-5|display-authors=etal}}
• {{cite journal | vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000 | pmc=310948 }}
• {{cite journal | vauthors=Matsuda S, Iriyama C, Yokozaki S |title=Cloning and sequencing of a novel human gene that encodes a putative target protein of Nesh-SH3. |journal=J. Hum. Genet. |volume=46 |issue= 8 |pages= 483–6 |year= 2001 |pmid= 11501947 |doi=10.1007/s100380170049 |display-authors=etal|doi-access=free }}
• {{cite journal | vauthors=Ichigotani Y, Yokozaki S, Fukuda Y |title=Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells. |journal=Cancer Res. |volume=62 |issue= 8 |pages= 2215–9 |year= 2002 |pmid= 11956071 |display-authors=etal}}
• {{cite journal | vauthors=Wiemann S, Arlt D, Huber W |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930 |display-authors=etal}}
• {{cite journal | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 |display-authors=etal}}
• {{cite journal | vauthors=Mehrle A, Rosenfelder H, Schupp I |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501 |display-authors=etal}}
• {{cite journal | vauthors=Hirao N, Sato S, Gotoh T |title=NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation. |journal=FEBS Lett. |volume=580 |issue= 27 |pages= 6464–70 |year= 2007 |pmid= 17101133 |doi= 10.1016/j.febslet.2006.10.065 |s2cid=20005197 |display-authors=etal|doi-access=free }}

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{{DEFAULTSORT:Abi3}}

{{gene-17-stub}}