ACTR1B
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Beta-centractin is a protein that in humans is encoded by the ACTR1B gene.{{cite journal | vauthors = Clark SW, Staub O, Clark IB, Holzbaur EL, Paschal BM, Vallee RB, Meyer DI | title = Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins | journal = Mol Biol Cell | volume = 5 | issue = 12 | pages = 1301–10 |date=May 1995 | pmid = 7696711 | pmc = 301159 | doi = 10.1091/mbc.5.12.1301}}{{cite journal | vauthors = Elsea SH, Clark IB, Juyal RC, Meyer DJ, Meyer DI, Patel PI | title = Assignment of beta-centractin (CTRN2) to human chromosome 2 bands q11.1→q11.2 with somatic cell hybrids and in situ hybridization | journal = Cytogenet Cell Genet | volume = 84 | issue = 1–2 | pages = 48–9 |date=Jun 1999 | pmid = 10343100 | doi =10.1159/000015211 | s2cid = 83665096 }}{{cite web | title = Entrez Gene: ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10120}}
This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related protein. These two proteins are of equal length and share 90% amino acid identity. They are present in a constant ratio of approximately 1:15 in the dynactin complex.
References
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Further reading
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- {{cite journal | vauthors=Hillier LW, Graves TA, Fulton RS |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4 |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 |bibcode=2005Natur.434..724H |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Eckley DM, Schroer TA |title=Interactions between the evolutionarily conserved, actin-related protein, Arp11, actin, and Arp1 |journal=Mol. Biol. Cell |volume=14 |issue= 7 |pages= 2645–54 |year= 2004 |pmid= 12857853 |doi= 10.1091/mbc.E03-01-0049 | pmc=165665 }}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal |bibcode=2002PNAS...9916899M|doi-access=free }}
- {{cite journal | vauthors=Simpson JC, Wellenreuther R, Poustka A |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 | pmc=1083732 |display-authors=etal}}
- {{cite journal | vauthors=Adams MD, Dubnick M, Kerlavage AR |title=Sequence identification of 2,375 human brain genes |journal=Nature |volume=355 |issue= 6361 |pages= 632–4 |year= 1992 |pmid= 1538749 |doi= 10.1038/355632a0 |bibcode=1992Natur.355..632A |s2cid=4234345 |display-authors=etal}}
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External links
- {{UCSC genome browser|ACTR1B}}
- {{UCSC gene details|ACTR1B}}
{{DEFAULTSORT:Actr1b}}
{{gene-2-stub}}