ADAM9

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Two alternative splice variants have been identified, encoding distinct isoforms.

ADAM9 has been shown to interact with:

• MAD2L2,{{cite journal | date = Nov 1999 | vauthors = Nelson KK, Schlöndorff J, Blobel CP | title = Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta | journal = Biochem. J. | volume = 343 | issue = Pt 3| pages = 673–80 | pmid = 10527948 | pmc = 1220601 | doi = 10.1042/0264-6021:3430673}}
• SH3GL2, and
• SNX9{{cite journal | date = Oct 1999 | vauthors = Howard L, Nelson KK, Maciewicz RA, Blobel CP | title = Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1 | journal = J. Biol. Chem. | volume = 274 | issue = 44 | pages = 31693–9 | pmid = 10531379 | doi = 10.1074/jbc.274.44.31693| doi-access = free }}

{{reflist}}

{{refbegin | 2}}

• {{cite journal | vauthors = Mazzocca A, Coppari R, De Franco R, Cho JY, Libermann TA, Pinzani M, Toker A | title = A secreted form of ADAM9 promotes carcinoma invasion through tumor-stromal interactions | journal = Cancer Res. | volume = 65 | issue = 11 | pages = 4728–38 |date=June 2005| pmid = 15930291 | doi = 10.1158/0008-5472.CAN-04-4449 | doi-access = free }}
• {{cite journal | vauthors=Nomura N, Miyajima N, Sazuka T |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. |journal=DNA Res. |volume=1 |issue= 1 |pages= 27–35 |year= 1995 |pmid= 7584026 |doi=10.1093/dnares/1.1.27 |display-authors=etal|doi-access=free }}
• {{cite journal | vauthors=Nomura N, Miyajima N, Sazuka T |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement). |journal=DNA Res. |volume=1 |issue= 1 |pages= 47–56 |year= 1995 |pmid= 7584028 |doi=10.1093/dnares/1.1.47 |display-authors=etal|doi-access=free }}
• {{cite journal | vauthors=McKie N, Dallas DJ, Edwards T |title=Cloning of a novel membrane-linked metalloproteinase from human myeloma cells. |journal=Biochem. J. |volume=318 |issue= 2|pages= 459–62 |year= 1996 |pmid= 8809033 |doi= 10.1042/bj3180459| pmc=1217643 |display-authors=etal}}
• {{cite journal | vauthors=McKie N, Edwards T, Dallas DJ |title=Expression of members of a novel membrane linked metalloproteinase family (ADAM) in human articular chondrocytes. |journal=Biochem. Biophys. Res. Commun. |volume=230 |issue= 2 |pages= 335–9 |year= 1997 |pmid= 9016778 |doi= 10.1006/bbrc.1996.5957 |display-authors=etal|bibcode=1997BBRC..230..335M }}
• {{cite journal | vauthors=Izumi Y, Hirata M, Hasuwa H |title=A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. |journal=EMBO J. |volume=17 |issue= 24 |pages= 7260–72 |year= 1999 |pmid= 9857183 |doi= 10.1093/emboj/17.24.7260 | pmc=1171072 |display-authors=etal}}
• {{cite journal | vauthors=Roghani M, Becherer JD, Moss ML |title=Metalloprotease-disintegrin MDC9: intracellular maturation and catalytic activity. |journal=J. Biol. Chem. |volume=274 |issue= 6 |pages= 3531–40 |year= 1999 |pmid= 9920899 |doi=10.1074/jbc.274.6.3531 |display-authors=etal|doi-access= free}}
• {{cite journal | vauthors=Nelson KK, Schlöndorff J, Blobel CP |title=Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta. |journal=Biochem. J. |volume=343 |issue= 3|pages= 673–80 |year= 2000 |pmid= 10527948 |doi= 10.1042/0264-6021:3430673| pmc=1220601 }}
• {{cite journal | vauthors=Howard L, Nelson KK, Maciewicz RA, Blobel CP |title=Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1. |journal=J. Biol. Chem. |volume=274 |issue= 44 |pages= 31693–9 |year= 1999 |pmid= 10531379 |doi=10.1074/jbc.274.44.31693 |doi-access=free }}
• {{cite journal | vauthors=Zhou M, Graham R, Russell G, Croucher PI |title=MDC-9 (ADAM-9/Meltrin gamma) functions as an adhesion molecule by binding the alpha(v)beta(5) integrin. |journal=Biochem. Biophys. Res. Commun. |volume=280 |issue= 2 |pages= 574–80 |year= 2001 |pmid= 11162558 |doi= 10.1006/bbrc.2000.4155 }}
• {{cite journal | vauthors=Namba K, Nishio M, Mori K |title=Involvement of ADAM9 in multinucleated giant cell formation of blood monocytes. |journal=Cell. Immunol. |volume=213 |issue= 2 |pages= 104–13 |year= 2002 |pmid= 11831872 |doi= 10.1006/cimm.2001.1873 |display-authors=etal}}
• {{cite journal | vauthors=Eto K, Huet C, Tarui T |title=Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions. |journal=J. Biol. Chem. |volume=277 |issue= 20 |pages= 17804–10 |year= 2002 |pmid= 11882657 |doi= 10.1074/jbc.M200086200 |display-authors=etal|doi-access=free }}
• {{cite journal | vauthors=Lim JM, Lee JH, Wee WR, Joo CK |title=Downregulated expression of ADAM9 in anterior polar cataracts. |journal=Journal of Cataract and Refractive Surgery |volume=28 |issue= 4 |pages= 697–702 |year= 2002 |pmid= 11955914 |doi=10.1016/S0886-3350(01)01236-6 |s2cid=21982654 }}
• {{cite journal | vauthors=Hotoda N, Koike H, Sasagawa N, Ishiura S |title=A secreted form of human ADAM9 has an alpha-secretase activity for APP. |journal=Biochem. Biophys. Res. Commun. |volume=293 |issue= 2 |pages= 800–5 |year= 2002 |pmid= 12054541 |doi= 10.1016/S0006-291X(02)00302-9 |bibcode=2002BBRC..293..800H }}
• {{cite journal | vauthors=Amour A, Knight CG, English WR |title=The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs. |journal=FEBS Lett. |volume=524 |issue= 1–3 |pages= 154–8 |year= 2002 |pmid= 12135759 |doi=10.1016/S0014-5793(02)03047-8 |s2cid=37423323 |display-authors=etal|doi-access=free |bibcode=2002FEBSL.524..154A }}
• {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
• {{cite journal | vauthors=Mohan S, Thompson GR, Amaar YG |title=ADAM-9 is an insulin-like growth factor binding protein-5 protease produced and secreted by human osteoblasts |journal=Biochemistry |volume=41 |issue= 51 |pages= 15394–403 |year= 2003 |pmid= 12484779 |doi=10.1021/bi026458q |display-authors=etal}}
• {{cite journal | vauthors=Asai M, Hattori C, Szabó B |title=Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase |journal=Biochem. Biophys. Res. Commun. |volume=301 |issue= 1 |pages= 231–5 |year= 2003 |pmid= 12535668 |doi=10.1016/S0006-291X(02)02999-6 |display-authors=etal|bibcode=2003BBRC..301..231A }}
• {{cite journal | vauthors=O'Shea C, McKie N, Buggy Y |title=Expression of ADAM-9 mRNA and protein in human breast cancer |journal=Int. J. Cancer |volume=105 |issue= 6 |pages= 754–61 |year= 2003 |pmid= 12767059 |doi= 10.1002/ijc.11161 |s2cid=19284959 |display-authors=etal|doi-access=free }}
• {{cite journal | vauthors=Grützmann R, Lüttges J, Sipos B |title=ADAM9 expression in pancreatic cancer is associated with tumour type and is a prognostic factor in ductal adenocarcinoma |journal=Br. J. Cancer |volume=90 |issue= 5 |pages= 1053–8 |year= 2004 |pmid= 14997207 |doi= 10.1038/sj.bjc.6601645 | pmc=2409625 |display-authors=etal}}

{{refend}}

• [http://AtlasGeneticsOncology.org/Genes/ADAM9ID573ch8p11.html ADAM9] on the Atlas of Genetics and Oncology
• {{UCSC gene info|ADAM9}}

{{Metalloproteinases}}

Category:Proteases

Category:EC 3.4.24

{{gene-8-stub}}