SH3GL2
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Endophilin-A1 is a protein that in humans is encoded by the SH3GL2 gene.{{cite journal |author1=Giachino C |author2=Lantelme E |author3=Lanzetti L |author4=Saccone S |author5=Bella Valle G |author6=Migone N | title = A novel SH3-containing human gene family preferentially expressed in the central nervous system | journal = Genomics | volume = 41 | issue = 3 | pages = 427–34 |date=Jul 1997 | pmid = 9169142 | doi =10.1006/geno.1997.4645 }}{{cite web | title = Entrez Gene: SH3GL2 SH3-domain GRB2-like 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6456}}
Interactions
SH3GL2 has been shown to interact with DNM1,{{cite journal |doi=10.1074/jbc.272.43.27239 |last=Micheva |first=K D |author2=Kay B K |author3=McPherson P S |date=Oct 1997 |title=Synaptojanin forms two separate complexes in the nerve terminal. Interactions with endophilin and amphiphysin |journal=J. Biol. Chem. |volume=272 |issue=43 |pages=27239–45 |location = UNITED STATES| issn = 0021-9258| pmid = 9341169 |doi-access=free }}{{cite journal |last=Modregger |first=Jan |author2=Schmidt Anne A |author3=Ritter Brigitte |author4=Huttner Wieland B |author5=Plomann Markus |date=Feb 2003 |title=Characterization of Endophilin B1b, a brain-specific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1 |journal=J. Biol. Chem. |volume=278 |issue=6 |pages=4160–7 |location = United States| issn = 0021-9258| pmid = 12456676 |doi = 10.1074/jbc.M208568200 |doi-access=free }} Amphiphysin, ADAM9,{{cite journal |doi=10.1074/jbc.274.44.31693 |last=Howard |first=L |author2=Nelson K K |author3=Maciewicz R A |author4=Blobel C P |date=Oct 1999 |title=Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1 |journal=J. Biol. Chem. |volume=274 |issue=44 |pages=31693–9 |location = UNITED STATES| issn = 0021-9258| pmid = 10531379 |doi-access=free }} SH3KBP1{{cite journal |last=Soubeyran |first=Philippe |author2=Kowanetz Katarzyna |author3=Szymkiewicz Iwona |author4=Langdon Wallace Y |author5=Dikic Ivan |date=Mar 2002 |title=Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors |journal=Nature |volume=416 |issue=6877 |pages=183–7 |location = England| issn = 0028-0836| pmid = 11894095 |doi = 10.1038/416183a | bibcode =2002Natur.416..183S |s2cid=635702 }} and ADAM15.
References
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Further reading
{{refbegin | 2}}
- {{cite journal | author=Ren Y, Fang F, Davey F, Taylor M, Aiton J, Coote P, Yao J, Chen JX, Yan SD & Gunn-Moore FJ. |title=Endophilin I expression is increased in the brains of Alzheimer's disease patients. |journal=Journal of Biological Chemistry |volume=283 |pages= 5685–91 |year= 2008 | pmid=18167351 | issue=9 | doi=10.1074/jbc.M707932200|doi-access=free}}
- {{cite journal |author1=Reutens AT |author2=Begley CG |title=Endophilin-1: a multifunctional protein. |journal=Int. J. Biochem. Cell Biol. |volume=34 |issue= 10 |pages= 1173–7 |year= 2002 |pmid= 12127567 |doi=10.1016/S1357-2725(02)00063-8 }}
- {{cite journal |vauthors=So CW, Caldas C, Liu MM, etal |title=EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 6 |pages= 2563–8 |year= 1997 |pmid= 9122235 |doi=10.1073/pnas.94.6.2563 | pmc=20128 |bibcode=1997PNAS...94.2563S |doi-access=free }}
- {{cite journal |author1=Ringstad N |author2=Nemoto Y |author3=De Camilli P |title=The SH3p4/Sh3p8/SH3p13 protein family: binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 16 |pages= 8569–74 |year= 1997 |pmid= 9238017 |doi=10.1073/pnas.94.16.8569 | pmc=23017 |bibcode=1997PNAS...94.8569R |doi-access=free }}
- {{cite journal |author1=Micheva KD |author2=Ramjaun AR |author3=Kay BK |author4=McPherson PS |title=SH3 domain-dependent interactions of endophilin with amphiphysin. |journal=FEBS Lett. |volume=414 |issue= 2 |pages= 308–12 |year= 1997 |pmid= 9315708 |doi=10.1016/S0014-5793(97)01016-8 |s2cid=21328416 |doi-access=free }}
- {{cite journal |author1=Micheva KD |author2=Kay BK |author3=McPherson PS |title=Synaptojanin forms two separate complexes in the nerve terminal. Interactions with endophilin and amphiphysin. |journal=J. Biol. Chem. |volume=272 |issue= 43 |pages= 27239–45 |year= 1997 |pmid= 9341169 |doi=10.1074/jbc.272.43.27239 |doi-access=free }}
- {{cite journal |author1=Howard L |author2=Nelson KK |author3=Maciewicz RA |author4=Blobel CP |title=Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1. |journal=J. Biol. Chem. |volume=274 |issue= 44 |pages= 31693–9 |year= 1999 |pmid= 10531379 |doi=10.1074/jbc.274.44.31693 |doi-access=free }}
- {{cite journal |vauthors=Tang Y, Hu LA, Miller WE, etal |title=Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 22 |pages= 12559–64 |year= 1999 |pmid= 10535961 |doi=10.1073/pnas.96.22.12559 | pmc=22990 |bibcode=1999PNAS...9612559T |doi-access=free }}
- {{cite journal |vauthors=Cestra G, Castagnoli L, Dente L, etal |title=The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity. |journal=J. Biol. Chem. |volume=274 |issue= 45 |pages= 32001–7 |year= 1999 |pmid= 10542231 |doi=10.1074/jbc.274.45.32001 |doi-access=free }}
- {{cite journal |vauthors=So CW, So CK, Cheung N, etal |title=The interaction between EEN and Abi-1, two MLL fusion partners, and synaptojanin and dynamin: implications for leukaemogenesis. |journal=Leukemia |volume=14 |issue= 4 |pages= 594–601 |year= 2000 |pmid= 10764144 |doi=10.1038/sj.leu.2401692 |doi-access=free }}
- {{cite journal |vauthors=So CW, Sham MH, Chew SL, etal |title=Expression and protein-binding studies of the EEN gene family, new interacting partners for dynamin, synaptojanin and huntingtin proteins. | volume=348 |journal=Biochem. J. |issue= 2|pages= 447–58 |year= 2000 |pmid= 10816441 |doi=10.1042/0264-6021:3480447 | pmc=1221085 }}
- {{cite journal |vauthors=Zucconi A, Dente L, Santonico E, etal |title=Selection of ligands by panning of domain libraries displayed on phage lambda reveals new potential partners of synaptojanin 1. |journal=J. Mol. Biol. |volume=307 |issue= 5 |pages= 1329–39 |year= 2001 |pmid= 11292345 |doi= 10.1006/jmbi.2001.4572 }}
- {{cite journal |vauthors=Ramjaun AR, Angers A, Legendre-Guillemin V, etal |title=Endophilin regulates JNK activation through its interaction with the germinal center kinase-like kinase. |journal=J. Biol. Chem. |volume=276 |issue= 31 |pages= 28913–9 |year= 2001 |pmid= 11384986 |doi= 10.1074/jbc.M103198200 |doi-access= free }}
- {{cite journal |author1=Chen-Hwang MC |author2=Chen HR |author3=Elzinga M |author4=Hwang YW |title=Dynamin is a minibrain kinase/dual specificity Yak1-related kinase 1A substrate. |journal=J. Biol. Chem. |volume=277 |issue= 20 |pages= 17597–604 |year= 2002 |pmid= 11877424 |doi= 10.1074/jbc.M111101200 |doi-access=free }}
- {{cite journal |vauthors=Soubeyran P, Kowanetz K, Szymkiewicz I, etal |title=Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors. |journal=Nature |volume=416 |issue= 6877 |pages= 183–7 |year= 2002 |pmid= 11894095 |doi= 10.1038/416183a |bibcode=2002Natur.416..183S |s2cid=635702 }}
- {{cite journal |vauthors=Petrelli A, Gilestro GF, Lanzardo S, etal |title=The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met. |journal=Nature |volume=416 |issue= 6877 |pages= 187–90 |year= 2002 |pmid= 11894096 |doi= 10.1038/416187a |bibcode=2002Natur.416..187P |s2cid=4389099 }}
- {{cite journal |vauthors=Chatellard-Causse C, Blot B, Cristina N, etal |title=Alix (ALG-2-interacting protein X), a protein involved in apoptosis, binds to endophilins and induces cytoplasmic vacuolization. |journal=J. Biol. Chem. |volume=277 |issue= 32 |pages= 29108–15 |year= 2002 |pmid= 12034747 |doi= 10.1074/jbc.M204019200 |doi-access= free }}
- {{cite journal |vauthors=Szymkiewicz I, Kowanetz K, Soubeyran P, etal |title=CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases. |journal=J. Biol. Chem. |volume=277 |issue= 42 |pages= 39666–72 |year= 2002 |pmid= 12177062 |doi= 10.1074/jbc.M205535200 |doi-access= free }}
- {{cite journal |author1=Haglund K |author2=Shimokawa N |author3=Szymkiewicz I |author4=Dikic I |title=Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 19 |pages= 12191–6 |year= 2002 |pmid= 12218189 |doi= 10.1073/pnas.192462299 | pmc=129420 |bibcode=2002PNAS...9912191H |doi-access=free }}
- {{cite journal |vauthors=Verstreken P, Kjaerulff O, Lloyd TE, etal |title= Endophilin mutations block clathrin-mediated endocytosis but not neurotransmitter release.
|journal= Cell |volume=109 |issue= 1 |pages= 101–12 |year= 2002
|pmid= 11955450 |doi= 10.1016/S0092-8674(02)00688-8 |s2cid= 11752921
|doi-access= free }}
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{{PDB Gallery|geneid=6456}}
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