AION Labs

AION Labs was formed after winning a government tender in 2020, bringing together AstraZeneca, Merck KGaA, Pfizer, and Teva—from the pharmaceutical sector—with Amazon Web Services (AWS), a technology and cloud computing provider, and biotech and deeptech VC firms Israel Biotech Fund and Amiti Ventures. The Management team of the company includes CEO Mati Gill,{{Cite web |title=The Israel-America Chamber of Commerce - Mati Gill |url=https://www.amcham.co.il/he/about/board-of-directors/mati-gill |access-date=2024-07-12 |website=www.amcham.co.il}}{{Cite web |title=Mati Gill |url=https://biomedmanagement.tau.ac.il/faculty/mati-gill/ |access-date=2024-07-12 |website=Healthcare Technological Innovation Program - Lahav |language=en-US}} CTO Yair Benita,{{Cite web |last=Ben-David |first=Ricky |date=14 October 2021 |title=New innovation lab brings together pharma, biotech giants for AI therapeutics |url=https://www.timesofisrael.com/new-innovation-lab-brings-together-pharma-biotech-giants-for-ai-therapeutics/ |access-date=2024-07-12 |website=timesofisrael.com}} Dr. Sharon Kredo-Russo (VP Ideation), Sharon Gour Arie (VP Value Creation), Einav Daniel (Finance Director), Yael Spector (Scientific Project Manager), Moran Mamluk (Administrative Operations Manager), and Dr. Arnon Fluksman (Scientific Analyst).

In 2022 and 2023, it was nominated for the Prix Galien USA Award for its work in AI and healthcare{{Cite web |last=Lovegrove |first=Gemma |date=2022-08-18 |title=Prix Galien USA award nominees announced |url=https://ai-med.io/more-news/prix-galien-usa-award-nominees-announced/ |access-date=2024-07-12 |website=AIMed |language=en-GB}} and awarded "Most Valuable Collaboration Award" by Reuters Pharma Awards USA 2022.{{Cite web |title=Pharma Awards USA 2024 |url=https://events.reutersevents.com/pharma/awards-usa/winners |access-date=2024-07-12 |website=events.reutersevents.com |language=en-us}}

In February 2023, AION Labs introduced DenovAI, a venture focused on antibody discovery through an AI-powered computational platform. DenovAI's technology is designed to discover antibodies de novo, expediting and economizing the process.{{Cite web |date=2023-02-28 |title=AION Labs launches second startup focused on AI-enabled antibody design |url=https://www.mobihealthnews.com/news/aion-labs-launches-second-startup-focused-ai-enabled-antibody-design |access-date=2024-07-12 |website=MobiHealthNews |language=en}}{{Cite web |last=Blizovsky |first=Avi |date=March 4, 2023 |title=AION Labs is establishing the startup DenovAI that will deal with the design of antibodies and drugs |url=https://hayadan.com/aion-labs-%D7%9E%D7%A7%D7%99%D7%9E%D7%94-%D7%90%D7%AA-%D7%94%D7%A1%D7%98%D7%90%D7%A8%D7%98-%D7%90%D7%A4-denovai-%D7%A9%D7%99%D7%A2%D7%A1%D7%95%D7%A7-%D7%91%D7%AA%D7%9B%D7%A0%D7%95%D7%9F |access-date=2024-07-12 |website=hayadan.com}}

In January 2024, AION Labs unveiled TenAces Biosciences,{{Cite web |last=Goldberg |first=Niva |date=2024-01-31 |title=Israel's Aion Labs Establishes TenAces to Develop New Molecular Glue Therapies |url=https://jewishbusinessnews.com/2024/01/31/israels-aion-labs-establishes-tenaces-to-develop-new-molecular-glue-therapies/ |access-date=2024-07-12 |language=en-US}}{{Cite web |last=Jaffe-Hoffman |first=Maayan |date=2024-02-03 |title=AION Labs unveils TenAces start-up, will use AI to predict molecular glues |url=https://www.jpost.com/business-and-innovation/tech-and-start-ups/article-785010 |access-date=2024-07-12 |website=The Jerusalem Post {{!}} JPost.com |language=en}} a venture in the field of molecular glue discovery using machine learning. Formed from AION Labs' initiative to develop AI platforms for targeted protein degradation, TenAces focuses on accelerating the discovery and development of new molecular glue therapies.{{Cite web |last=Sohail |first=Syed Hamza |date=2024-01-30 |title=Molecular Glue Revolution: TenAces Biosciences Unveils AI-Powered Drug Discovery Platform |url=https://hitconsultant.net/2024/01/30/molecular-glue-revolution-tenaces-biosciences-unveils-ai-powered-drug-discovery-platform/ |access-date=2024-07-12 |website=hitconsultant.net |language=en-US}}

In February 2024, the challenge of developing an AI/ML platform for Targeting RNA with Small Molecules was launched via a Call for Applications.{{Cite web |title=התוכנית הזאת הופכת רעיונות לסטארטאפ – מהמחקר ועד גיוס משקיעים |trans-title=This program turns ideas into startups - from research to recruiting investors |url=https://www.geektime.co.il/ai-rna-challenge-2024/ |access-date=2024-07-12 |website=geektime.co.il |date=21 March 2024 |language=he}}

In March 2024, it launched CombinAble.AI, a startup resulting from an AION Labs' startup challenge aimed at the antibody design process.{{Cite web |date=2024-03-12 |title=סטארט-אפ בינה מלאכותית חדש בישראל: זה התחום בו יעסוק |url=https://www.ice.co.il/digital-140/news/article/1004594 |access-date=2024-07-12 |website=Ice |language=he}}{{Cite web |date=2024-03-15 |title=AION Labs launches CombinAble.AI to design antibodies for therapeutic development |url=https://www.mobihealthnews.com/news/aion-labs-launches-combinableai-design-antibodies-therapeutic-development |access-date=2024-07-12 |website=MobiHealthNews |language=en}}

In April 2024, AION Labs launched a global challenge seeking scientists to develop an AI/machine learning platform for RNA targeting with small molecules.{{Cite web |last=Miller |first=Sara |date=2024-04-01 |title=In Israel, Big Pharma Innovators Are Using Tech To Fight Disease |url=https://nocamels.com/2024/04/in-israel-big-pharma-innovators-are-using-tech-to-fight-disease/ |access-date=2025-03-12 |website=NoCamels}}

In October 2024, AION Labs launched ProPhet, a startup using machine learning technologies, including diffusion models and large language models, to identify active small molecules for drug discovery, particularly targeting proteins with limited information.{{Cite web |last=Vecchione |first=Anthony

|date=2024-10-30 |title=AION Labs introduces AI startup to hasten identification of active small molecules |url=https://www.mobihealthnews.com/news/aion-labs-introduces-ai-startup-hasten-identification-active-small-molecules |access-date=2025-03-12 |website=MobiHealthNews |language=en}}{{Cite web |last=Ringel |first=Shai |title=יוזמת חדשנות משותפת של ענקיות התרופות משיקה סטארט-אפ ישראלי |url=https://www.mako.co.il/nexter-news/Article-c8d13ec6a78d291027.htm |access-date=2025-03-12 |website=mako |language=he}}

In December 2024, Promise Bio, an AION Labs portfolio company, emerged from stealth mode with an $8.3 million Seed investment led by Awz Ventures, with funding from AstraZeneca, Pfizer, and the Israel Innovation Authority. The startup, recognized among TechCrunch's "51 Most Disruptive Startups of 2024," developed an AI-powered epiproteomic platform for precision medicine in autoimmune diseases.{{Cite web |last=Spiro |first=James |title=Promise Bio emerges from stealth with $8.3 million Seed for AI-powered epiproteomics platform |url=https://www.calcalistech.com/ctechnews/article/bk7gpunvyl |access-date=2025-03-12 |website=Calcalist}}{{Cite web |last=Shieber |first=Jonathan |date=2024-12-13 |title=The 51 most disruptive startups of 2024 |url=https://techcrunch.com/2024/12/13/the-51-most-disruptive-startups-of-2024/ |access-date=2025-03-12 |website=TechCrunch}}

In February 2025, AION Labs was included in TBRC Business Research's report on key players in the global Generative Artificial Intelligence in Material Science market.{{Cite web |date=2025-02-28 |title=Leading Driver In The Generative AI In Material Science Market 2025: AI Technologies Propel Growth Of The Industry |url=https://www.einpresswire.com/article/788660767/leading-driver-in-the-generative-ai-in-material-science-market-2025-ai-technologies-propel-growth-of-the-industry |access-date=2025-03-12 |website=EIN Presswire}}{{Cite web |title=Artificial Intelligence (AI) In Ultrasound Imaging Global Market Report |url=https://www.thebusinessresearchcompany.com/report/artificial-intelligence-ai-in-ultrasound-imaging-global-market-report |access-date=2025-03-12 |website=The Business Research Company}}

In March 2025, AION Labs and BioMed X launched a global call for applications titled "Generative AI for Novel Target Combinations," seeking to develop an AI platform to identify and validate target combinations for multispecific biologic drugs targeting cancer, cardiovascular-kidney-metabolic diseases, and immune disorders.{{Cite web |date=2025-03-05 |title=AION Labs in continued partnership with BioMed X launches 2025 global call for applications: Generative AI for Novel Target Combinations |url=https://infomeddnews.com/aion-labs-news-3525/ |access-date=2025-03-12 |website=InfoMed News}}{{Cite web |date=2025-03-05 |title=AION Labs in continued partnership with BioMed X launches 2025 global call for applications: Generative AI for Novel Target Combinations |url=https://bio.mx/news/press-releases/aion-labs-in-continued-partnership-with-biomed-x-launches-2025-global-call-for-applications-generative-ai-for-novel-target-combinations-012813/ |access-date=2025-03-12 |website=BioMed X}}

• Ohad Goldberg - President, AstraZeneca Israel
• Ezequiel Garfinkel - Head of Science & Technology, Merck KGaA
• Dr. Anthony Barry - Executive Director & ES&I Lead Biopharmaceuticals, Technologies & Digital R&D, Pfizer
• Eli Shani - SVP Global Business Development, Teva
• Sarit Steinberg - Partner, Israel Biotech Fund
• Dr. Yuval Cabily - Co-founder & Managing Partner, Israel Biotech Fund
• Ben Rabinowitz - Founder & Managing Partner, Amiti Ventures
• Guy Spigelman - EMEA Lead Healthcare & Life Sciences Startups, AWS {{Cite web |title=AION Labs Leadership |url=https://aionlabs.com/about/ |access-date=2025-03-13 |website=AION Labs}}

• Dr. James Weatherall - VP, Data Science & AI, R&D, AstraZeneca
• Dr. Stuart Bailey - SVP, Head of Clinical Measurement Sciences, Merck KGaA
• Dr. David Von Schack - Executive Director, Head, Systems Immunology; Inflammation & Immunology, Pfizer
• Dr. Steffen Nock - SVP Chief Scientific Officer, Teva
• Ido Zairi - Co-founder & Managing Partner, Israel Biotech Fund
• Dr. Boris Bogdan - Director EMEA Healthcare & Lifesciences, AWS {{Cite web |title=AION Labs Committees |url=https://aionlabs.com/about/ |access-date=2025-03-13 |website=AION Labs}}

• BioMed X Institute - Founded & led by Dr. Christian Tidona, the partnership focuses on building world-class innovation ecosystems for biomedical research, drug discovery and development{{Cite web |title=BioMed X and AION Labs announce strategic partnership |url=https://bio.mx/news/press-releases/aion-labs-in-continued-partnership-with-biomed-x-launches-2025-global-call-for-applications-generative-ai-for-novel-target-combinations-012813/ |access-date=2025-03-13 |website=BioMed X}}

AION Labs focuses on developing AI and computational technologies in drug discovery and development in the pharmaceutical industry. It aids in the creation of companies in the pharmaceutical sector. The studio's venture creation model leverages the BioMed X model and focuses on:{{Cite web |date=2020-04-20 |title=BioMed X: Tackling the unmet need in biomedical research & development {{!}} Business & Corporate News |url=https://www.bwmonline.com/2020/04/20/biomed-x-tackling-the-unmet-need-in-biomedical-research-development/ |access-date=2024-07-12 |language=en-GB}}

• identifying R&D challenges in drug discovery and development based on scientific/technological business opportunities and market needs;{{Cite web |title=ICDK Tel Aviv attracting multinational companies to the innovation ecosystem: Best practices from Israel |url=https://icdk.dk/-/media/websites/icdk/locations-reports/tel-aviv/icdk-tel-aviv-outlook-attracting-multinational-companies-to-the-innovation-ecosystem.ashx |access-date=2024-07-12 |website=icdk.dk |isbn=978-87-94128-61-2}}
• assembling multidisciplinary teams of scientist-founders and innovators through an application process and a week-long innovation workshop;
• offering resources, including an initial pre-seed investment of at least $1M, mentoring, proprietary data and access to an industry expert and investor network.{{Cite web |last=Jaffe-Hoffman |first=Maayan |date=2021-10-19 |title=Pfizer, AstraZeneca help launch 'computational science' lab in Israel |url=https://www.jpost.com/health-and-wellness/pfizer-astrazeneca-help-launch-computational-science-lab-in-israel-682248 |access-date=2024-07-12 |website=The Jerusalem Post {{!}} JPost.com |language=en}}

DenovAI focuses on expediting drug discovery by creating an AI-based platform designed to generate high-affinity therapeutic antibodies and miniprotein binders for specific protein targets from scratch.

TenAces Biosciences is focused on advancing the development of molecular glue therapeutics designed for targeted protein degradation. Employing a data-centric approach and machine learning, TenAces explores protein interactions, pairs, and multi-dimensional features to predict new molecular glues to enhance therapeutic outcomes.{{Cite news |last=וינרב |first=גלי |date=2024-02-11 |title=המוצר הישראלי שהקפיץ את מניית התרופות האמריקאית ב-42% |url=https://www.globes.co.il/news/article.aspx?did=1001470887 |access-date=2024-07-12 |work=Globes}}

Combinable.AI focuses on addressing challenges in pharmaceutical development and manufacturing by developing an in silico method for optimizing antibody properties simultaneously. This approach aims to speed up the drug discovery process by identifying multiple candidates that achieve a balanced profile across diverse characteristics, reducing the reliance on trial-and-error methods.{{Cite web |last=Dargan |first=James |date=2024-03-21 |title=AION Labs Unveils CombinAble.AI, Aimed at Crafting Antibodies for Therapeutics, Following Its Fifth Startup Challenge in Israel |url=https://theaiinsider.tech/2024/03/21/aion-labs-unveils-combinable-ai-aimed-at-crafting-antibodies-for-therapeutics-following-its-fifth-startup-challenge-in-israel/ |access-date=2024-07-12 |website=AI Insider |language=en-US}}{{Cite web |date=2024-03-19 |title=AION Labs Launches CombinAble |url=https://distilinfo.com/hospitalit/2024/03/19/aion-labs-launches-combinable/ |access-date=2024-07-12 |language=en-US}}

Omec.AI focuses on improving the likelihood of success for drug candidates in clinical trials through the analysis of pre-clinical safety and efficacy data. The platform builds computational models to detect potential safety concerns and efficacy issues early in the drug development process.{{Cite web |last=McNamee |first=Aidan |date=2023-05-30 |title=AION Labs and BioMed X launch sixth challenge for AI-driven drug discovery |url=https://www.pharmaceutical-technology.com/news/aion-labs-biomedx-launch-challenge-ai-drug-discovery/ |access-date=2024-07-12 |website=Pharmaceutical Technology |language=en-US}}

Promise Bio is developing a platform for unbiased, broad-range epiproteomic analysis focused on precision medicine applications for complex chronic conditions, including autoimmune diseases. Their cloud-based system is designed to provide timely clinical insights that enable personalized treatment approaches and response predictions.{{Cite web |last=Solomon |first=Shoshanna |title=Promise Bio emerges from stealth with $8.3 million Seed for AI-powered epiproteomics platform |url=https://www.calcalistech.com/ctechnews/article/bk7gpunvyl |access-date=2025-03-12 |website=Calcalist}}

Cellyrix develops cancer treatment approaches by utilizing single-cell RNA sequencing and artificial intelligence to analyze tumor heterogeneity. Their platform aims to create targeted therapies addressing the underlying causes of disease progression, treatment resistance, and relapse to improve patient outcomes.{{Cite web |title=AION Labs portfolio |url=https://aionlabs.com/portfolio/ |access-date=2025-03-12 |website=AION Labs}}

Cassidy Bio, currently operating in stealth mode, specializes in advancing genome editing therapeutics, operating in stealth mode to develop novel treatments leveraging gene modification technologies.{{Cite web |title=Pitchbook - Cassidy Bio Overview |url=https://pitchbook.com/profiles/company/682926-94#overview |access-date=2025-03-12 |website=Pitchbook}}

ProPhet uses state-of-the-art Machine Learning technologies, including diffusion models and large language models, to identify active small molecules for drug discovery.{{Cite web |last=Vecchione |first=Anthony |date=2024-10-30 |title=AION Labs introduces AI startup to hasten identification of active small molecules |url=https://www.mobihealthnews.com/news/aion-labs-introduces-ai-startup-hasten-identification-active-small-molecules |access-date=2025-03-12 |website=MobiHealthNews |language=en}}{{Cite web |last=Ringel |first=Shai |date=2024-10-30 |title=יוזמת חדשנות משותפת של ענקיות התרופות משיקה סטארט-אפ ישראלי |url=https://www.mako.co.il/nexter-news/Article-c8d13ec6a78d291027.htm |access-date=2025-03-12 |website=mako |language=he}}

Category:Venture capital firms of Israel

Category:Financial services companies established in 2020

Category:2020 establishments in Israel

Category:Technology companies of Israel