AP2B1

The protein encoded by this gene is one of two large chain components of the AP2 adaptor complex, which serves to link clathrin to receptors in coated vesicles. The encoded protein is found on the cytoplasmic face of coated vesicles in the plasma membrane. Two transcript variants encoding different isoforms have been found for this gene.

AP2B1 has been shown to interact with:

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• AP1M2,{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R | s2cid = 4427026 }}
• Arrestin beta 2,{{cite journal | vauthors = Laporte SA, Oakley RH, Zhang J, Holt JA, Ferguson SS, Caron MG, Barak LS | title = The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 7 | pages = 3712–7 | date = Mar 1999 | pmid = 10097102 | pmc = 22359 | doi = 10.1073/pnas.96.7.3712| bibcode = 1999PNAS...96.3712L | doi-access = free }}{{cite journal | vauthors = Kim YM, Benovic JL | title = Differential roles of arrestin-2 interaction with clathrin and adaptor protein 2 in G protein-coupled receptor trafficking | journal = The Journal of Biological Chemistry | volume = 277 | issue = 34 | pages = 30760–8 | date = Aug 2002 | pmid = 12070169 | doi = 10.1074/jbc.M204528200 | doi-access = free }}
• BUB1B,{{cite journal | vauthors = Cayrol C, Cougoule C, Wright M | title = The beta2-adaptin clathrin adaptor interacts with the mitotic checkpoint kinase BubR1 | journal = Biochemical and Biophysical Research Communications | volume = 298 | issue = 5 | pages = 720–30 | date = Nov 2002 | pmid = 12419313 | doi = 10.1016/s0006-291x(02)02522-6}}
• LDLRAP1{{cite journal | vauthors = He G, Gupta S, Yi M, Michaely P, Hobbs HH, Cohen JC | title = ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 46 | pages = 44044–9 | date = Nov 2002 | pmid = 12221107 | doi = 10.1074/jbc.M208539200 | doi-access = free }} and
• TGF beta receptor 2.{{cite journal | vauthors = Yao D, Ehrlich M, Henis YI, Leof EB | title = Transforming growth factor-beta receptors interact with AP2 by direct binding to beta2 subunit | journal = Molecular Biology of the Cell | volume = 13 | issue = 11 | pages = 4001–12 | date = Nov 2002 | pmid = 12429842 | pmc = 133610 | doi = 10.1091/mbc.02-07-0104 }}

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• {{cite journal | vauthors = Kirchhausen T | title = Clathrin | journal = Annual Review of Biochemistry | volume = 69 | pages = 699–727 | year = 2000 | pmid = 10966473 | doi = 10.1146/annurev.biochem.69.1.699 }}
• {{cite journal | vauthors = Geyer M, Fackler OT, Peterlin BM | title = Structure--function relationships in HIV-1 Nef | journal = EMBO Reports | volume = 2 | issue = 7 | pages = 580–5 | date = Jul 2001 | pmid = 11463741 | pmc = 1083955 | doi = 10.1093/embo-reports/kve141 }}
• {{cite journal | vauthors = Ponnambalam S, Robinson MS, Jackson AP, Peiperl L, Parham P | title = Conservation and diversity in families of coated vesicle adaptins | journal = The Journal of Biological Chemistry | volume = 265 | issue = 9 | pages = 4814–20 | date = Mar 1990 | doi = 10.1016/S0021-9258(19)34045-1 | pmid = 1969413 | doi-access = free }}
• {{cite journal | vauthors = Greenberg ME, Bronson S, Lock M, Neumann M, Pavlakis GN, Skowronski J | title = Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation | journal = The EMBO Journal | volume = 16 | issue = 23 | pages = 6964–76 | date = Dec 1997 | pmid = 9384576 | pmc = 1170300 | doi = 10.1093/emboj/16.23.6964 }}
• {{cite journal | vauthors = Lim DS, Kirsch DG, Canman CE, Ahn JH, Ziv Y, Newman LS, Darnell RB, Shiloh Y, Kastan MB | title = ATM binds to beta-adaptin in cytoplasmic vesicles | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 17 | pages = 10146–51 | date = Aug 1998 | pmid = 9707615 | pmc = 21476 | doi = 10.1073/pnas.95.17.10146 | bibcode = 1998PNAS...9510146L | doi-access = free }}
• {{cite journal | vauthors = Greenberg M, DeTulleo L, Rapoport I, Skowronski J, Kirchhausen T | title = A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4 | journal = Current Biology | volume = 8 | issue = 22 | pages = 1239–42 | date = Nov 1998 | pmid = 9811611 | doi = 10.1016/S0960-9822(07)00518-0 | s2cid = 14272751 | doi-access = free | bibcode = 1998CBio....8.1239G }}
• {{cite journal | vauthors = Berlioz-Torrent C, Shacklett BL, Erdtmann L, Delamarre L, Bouchaert I, Sonigo P, Dokhelar MC, Benarous R | title = Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins | journal = Journal of Virology | volume = 73 | issue = 2 | pages = 1350–61 | date = Feb 1999 | pmid = 9882340 | pmc = 103959 | doi = 10.1128/JVI.73.2.1350-1361.1999}}
• {{cite journal | vauthors = Owen DJ, Vallis Y, Pearse BM, McMahon HT, Evans PR | title = The structure and function of the beta 2-adaptin appendage domain | journal = The EMBO Journal | volume = 19 | issue = 16 | pages = 4216–27 | date = Aug 2000 | pmid = 10944104 | pmc = 302036 | doi = 10.1093/emboj/19.16.4216 }}
• {{cite journal | vauthors = Fan GH, Yang W, Wang XJ, Qian Q, Richmond A | title = Identification of a motif in the carboxyl terminus of CXCR2 that is involved in adaptin 2 binding and receptor internalization | journal = Biochemistry | volume = 40 | issue = 3 | pages = 791–800 | date = Jan 2001 | pmid = 11170396 | pmc = 2664867 | doi = 10.1021/bi001661b }}
• {{cite journal | vauthors = Swigut T, Shohdy N, Skowronski J | title = Mechanism for down-regulation of CD28 by Nef | journal = The EMBO Journal | volume = 20 | issue = 7 | pages = 1593–604 | date = Apr 2001 | pmid = 11285224 | pmc = 145469 | doi = 10.1093/emboj/20.7.1593 }}
• {{cite journal | vauthors = Laporte SA, Miller WE, Kim KM, Caron MG | title = beta-Arrestin/AP-2 interaction in G protein-coupled receptor internalization: identification of a beta-arrestin binging site in beta 2-adaptin | journal = The Journal of Biological Chemistry | volume = 277 | issue = 11 | pages = 9247–54 | date = Mar 2002 | pmid = 11777907 | doi = 10.1074/jbc.M108490200 | doi-access = free }}
• {{cite journal | vauthors = Collins BM, McCoy AJ, Kent HM, Evans PR, Owen DJ | title = Molecular architecture and functional model of the endocytic AP2 complex | journal = Cell | volume = 109 | issue = 4 | pages = 523–35 | date = May 2002 | pmid = 12086608 | doi = 10.1016/S0092-8674(02)00735-3 | s2cid = 483953 | doi-access = free }}
• {{cite journal | vauthors = He G, Gupta S, Yi M, Michaely P, Hobbs HH, Cohen JC | title = ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 46 | pages = 44044–9 | date = Nov 2002 | pmid = 12221107 | doi = 10.1074/jbc.M208539200 | doi-access = free }}
• {{cite journal | vauthors = Cayrol C, Cougoule C, Wright M | title = The beta2-adaptin clathrin adaptor interacts with the mitotic checkpoint kinase BubR1 | journal = Biochemical and Biophysical Research Communications | volume = 298 | issue = 5 | pages = 720–30 | date = Nov 2002 | pmid = 12419313 | doi = 10.1016/S0006-291X(02)02522-6 }}
• {{cite journal | vauthors = Yao D, Ehrlich M, Henis YI, Leof EB | title = Transforming growth factor-beta receptors interact with AP2 by direct binding to beta2 subunit | journal = Molecular Biology of the Cell | volume = 13 | issue = 11 | pages = 4001–12 | date = Nov 2002 | pmid = 12429842 | pmc = 133610 | doi = 10.1091/mbc.02-07-0104 }}
• {{cite journal | vauthors = Kalthoff C, Groos S, Kohl R, Mahrhold S, Ungewickell EJ | title = Clint: a novel clathrin-binding ENTH-domain protein at the Golgi | journal = Molecular Biology of the Cell | volume = 13 | issue = 11 | pages = 4060–73 | date = Nov 2002 | pmid = 12429846 | pmc = 133614 | doi = 10.1091/mbc.E02-03-0171 }}

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• {{UCSC gene info|AP2B1}}

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