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Arrestin beta 2

{{Short description|Protein-coding gene in the species Homo sapiens}}

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{{Infobox_gene}}

Beta-arrestin-2, or β-arrestin2, also known as arrestin beta-2, is an intracellular protein that in humans is encoded by the ARRB2 gene.

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals,{{cite journal | vauthors = Breivogel CS, Lambert JM, Gerfin S, Huffman JW, Razdan RK | title = Sensitivity to delta9-tetrahydrocannabinol is selectively enhanced in beta-arrestin2 -/- mice | journal = Behavioural Pharmacology | volume = 19 | issue = 4 | pages = 298–307 | date = July 2008 | pmid = 18622177 | pmc = 2751575 | doi = 10.1097/FBP.0b013e328308f1e6 }}{{cite journal | vauthors = Li Y, Liu X, Liu C, Kang J, Yang J, Pei G, Wu C | title = Improvement of morphine-mediated analgesia by inhibition of β-arrestin2 expression in mice periaqueductal gray matter | journal = International Journal of Molecular Sciences | volume = 10 | issue = 3 | pages = 954–63 | date = March 2009 | pmid = 19399231 | pmc = 2672012 | doi = 10.3390/ijms10030954 | doi-access = free }}{{cite journal | vauthors = Zheng H, Loh HH, Law PY |author-link2=Horace Loh| title = Beta-arrestin-dependent mu-opioid receptor-activated extracellular signal-regulated kinases (ERKs) Translocate to Nucleus in Contrast to G protein-dependent ERK activation | journal = Molecular Pharmacology | volume = 73 | issue = 1 | pages = 178–90 | date = January 2008 | pmid = 17947509 | pmc = 2253657 | doi = 10.1124/mol.107.039842 }} as well as having signalling roles in their own right.{{cite journal | vauthors = Ma L, Pei G | title = Beta-arrestin signaling and regulation of transcription | journal = Journal of Cell Science | volume = 120 | issue = Pt 2 | pages = 213–8 | date = January 2007 | pmid = 17215450 | doi = 10.1242/jcs.03338 | doi-access = free }}{{cite journal | vauthors = Defea K | title = Beta-arrestins and heterotrimeric G-proteins: collaborators and competitors in signal transduction | journal = British Journal of Pharmacology | volume = 153 Suppl 1 | issue = S1 | pages = S298-309 | date = March 2008 | pmid = 18037927 | pmc = 2268080 | doi = 10.1038/sj.bjp.0707508 }}{{cite journal | vauthors = Barki-Harrington L, Rockman HA | title = Beta-arrestins: multifunctional cellular mediators | journal = Physiology | volume = 23 | pages = 17–22 | date = February 2008 | pmid = 18268361 | doi = 10.1152/physiol.00042.2007 }}{{cite journal | vauthors = Patel PA, Tilley DG, Rockman HA | title = Physiologic and cardiac roles of beta-arrestins | journal = Journal of Molecular and Cellular Cardiology | volume = 46 | issue = 3 | pages = 300–8 | date = March 2009 | pmid = 19103204 | doi = 10.1016/j.yjmcc.2008.11.015 }}{{cite journal | vauthors = Golan M, Schreiber G, Avissar S | title = Antidepressants, beta-arrestins and GRKs: from regulation of signal desensitization to intracellular multifunctional adaptor functions | journal = Current Pharmaceutical Design | volume = 15 | issue = 14 | pages = 1699–708 | year = 2009 | pmid = 19442183 | doi = 10.2174/138161209788168038 }} Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.{{cite web | title = ARRB2 arrestin beta 2 [ Homo sapiens (human) ]| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=409| publisher = National Center for Biotechnology Information}}

The protein may interact with the agonist DOI in 5-HT2A receptor signaling.{{cite journal | vauthors = Schmid CL, Raehal KM, Bohn LM | title = Agonist-directed signaling of the serotonin 2A receptor depends on beta-arrestin-2 interactions in vivo | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 105 | issue = 3 | pages = 1079–84 | date = January 2008 | pmid = 18195357 | pmc = 2242710 | doi = 10.1073/pnas.0708862105 | doi-access = free }}{{cite journal | vauthors = Abbas A, Roth BL|author2-link=Bryan Roth | title = Arresting serotonin | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 105 | issue = 3 | pages = 831–2 | date = January 2008 | pmid = 18195368 | pmc = 2242676 | doi = 10.1073/pnas.0711335105 | bibcode = 2008PNAS..105..831A | doi-access = free }}

Arrestin beta 2 is crucial for the development of tolerance to morphine and other opioids.

Interactions

Arrestin beta 2 has been shown to interact with

  • AP2B1,{{cite journal | vauthors = Laporte SA, Oakley RH, Zhang J, Holt JA, Ferguson SS, Caron MG, Barak LS | title = The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 7 | pages = 3712–7 | date = March 1999 | pmid = 10097102 | pmc = 22359 | doi = 10.1073/pnas.96.7.3712 | bibcode = 1999PNAS...96.3712L | doi-access = free }}{{cite journal | vauthors = Kim YM, Benovic JL | title = Differential roles of arrestin-2 interaction with clathrin and adaptor protein 2 in G protein-coupled receptor trafficking | journal = The Journal of Biological Chemistry | volume = 277 | issue = 34 | pages = 30760–8 | date = August 2002 | pmid = 12070169 | doi = 10.1074/jbc.M204528200 | doi-access = free }}
  • PSCD2,{{cite journal | vauthors = Claing A, Chen W, Miller WE, Vitale N, Moss J, Premont RT, Lefkowitz RJ | title = beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis | journal = The Journal of Biological Chemistry | volume = 276 | issue = 45 | pages = 42509–13 | date = November 2001 | pmid = 11533043 | doi = 10.1074/jbc.M108399200 | doi-access = free }}
  • Mdm2,{{cite journal | vauthors = Wang P, Gao H, Ni Y, Wang B, Wu Y, Ji L, Qin L, Ma L, Pei G | title = Beta-arrestin 2 functions as a G-protein-coupled receptor-activated regulator of oncoprotein Mdm2 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 8 | pages = 6363–70 | date = February 2003 | pmid = 12488444 | doi = 10.1074/jbc.M210350200 | doi-access = free }}{{cite journal | vauthors = Wang P, Wu Y, Ge X, Ma L, Pei G | title = Subcellular localization of beta-arrestins is determined by their intact N domain and the nuclear export signal at the C terminus | journal = The Journal of Biological Chemistry | volume = 278 | issue = 13 | pages = 11648–53 | date = March 2003 | pmid = 12538596 | doi = 10.1074/jbc.M208109200 | doi-access = free }}{{cite journal | vauthors = Shenoy SK, Xiao K, Venkataramanan V, Snyder PM, Freedman NJ, Weissman AM | title = Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor | journal = The Journal of Biological Chemistry | volume = 283 | issue = 32 | pages = 22166–76 | date = August 2008 | pmid = 18544533 | pmc = 2494938 | doi = 10.1074/jbc.M709668200 | doi-access = free }} and
  • RALGDS.{{cite journal | vauthors = Bhattacharya M, Anborgh PH, Babwah AV, Dale LB, Dobransky T, Benovic JL, Feldman RD, Verdi JM, Rylett RJ, Ferguson SS | title = Beta-arrestins regulate a Ral-GDS Ral effector pathway that mediates cytoskeletal reorganization | journal = Nature Cell Biology | volume = 4 | issue = 8 | pages = 547–55 | date = August 2002 | pmid = 12105416 | doi = 10.1038/ncb821 | s2cid = 20784208 }}

References

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Further reading

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  • {{cite journal | vauthors = Lefkowitz RJ | title = G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization | journal = The Journal of Biological Chemistry | volume = 273 | issue = 30 | pages = 18677–80 | date = July 1998 | pmid = 9668034 | doi = 10.1074/jbc.273.30.18677 | doi-access = free }}
  • {{cite journal | vauthors = Attramadal H, Arriza JL, Aoki C, Dawson TM, Codina J, Kwatra MM, Snyder SH, Caron MG, Lefkowitz RJ | title = Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family | journal = The Journal of Biological Chemistry | volume = 267 | issue = 25 | pages = 17882–90 | date = September 1992 | doi = 10.1016/S0021-9258(19)37125-X | pmid = 1517224 | doi-access = free }}
  • {{cite journal | vauthors = Rapoport B, Kaufman KD, Chazenbalk GD | title = Cloning of a member of the arrestin family from a human thyroid cDNA library | journal = Molecular and Cellular Endocrinology | volume = 84 | issue = 3 | pages = R39-43 | date = April 1992 | pmid = 1587386 | doi = 10.1016/0303-7207(92)90038-8 | s2cid = 1964362 }}
  • {{cite journal | vauthors = Calabrese G, Sallese M, Stornaiuolo A, Stuppia L, Palka G, De Blasi A | title = Chromosome mapping of the human arrestin (SAG), beta-arrestin 2 (ARRB2), and beta-adrenergic receptor kinase 2 (ADRBK2) genes | journal = Genomics | volume = 23 | issue = 1 | pages = 286–8 | date = September 1994 | pmid = 7695743 | doi = 10.1006/geno.1994.1497 }}
  • {{cite journal | vauthors = Parruti G, Peracchia F, Sallese M, Ambrosini G, Masini M, Rotilio D, De Blasi A | title = Molecular analysis of human beta-arrestin-1: cloning, tissue distribution, and regulation of expression. Identification of two isoforms generated by alternative splicing | journal = The Journal of Biological Chemistry | volume = 268 | issue = 13 | pages = 9753–61 | date = May 1993 | doi = 10.1016/S0021-9258(18)98412-7 | pmid = 8486659 | doi-access = free }}
  • {{cite journal | vauthors = Le Gouill C, Parent JL, Rola-Pleszczynski M, Stanková J | title = Role of the Cys90, Cys95 and Cys173 residues in the structure and function of the human platelet-activating factor receptor | journal = FEBS Letters | volume = 402 | issue = 2–3 | pages = 203–8 | date = February 1997 | pmid = 9037196 | doi = 10.1016/S0014-5793(96)01531-1 | s2cid = 21074692 | doi-access = free | bibcode = 1997FEBSL.402..203L }}
  • {{cite journal | vauthors = Barak LS, Ferguson SS, Zhang J, Caron MG | title = A beta-arrestin/green fluorescent protein biosensor for detecting G protein-coupled receptor activation | journal = The Journal of Biological Chemistry | volume = 272 | issue = 44 | pages = 27497–500 | date = October 1997 | pmid = 9346876 | doi = 10.1074/jbc.272.44.27497 | doi-access = free}}
  • {{cite journal | vauthors = Laporte SA, Oakley RH, Zhang J, Holt JA, Ferguson SS, Caron MG, Barak LS | title = The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 7 | pages = 3712–7 | date = March 1999 | pmid = 10097102 | pmc = 22359 | doi = 10.1073/pnas.96.7.3712 | bibcode = 1999PNAS...96.3712L | doi-access = free }}
  • {{cite journal | vauthors = Cheng ZJ, Zhao J, Sun Y, Hu W, Wu YL, Cen B, Wu GX, Pei G | title = beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4 | journal = The Journal of Biological Chemistry | volume = 275 | issue = 4 | pages = 2479–85 | date = January 2000 | pmid = 10644702 | doi = 10.1074/jbc.275.4.2479 | doi-access =free }}
  • {{cite journal | vauthors = Lin F, ((Wang Hy)), Malbon CC | title = Gravin-mediated formation of signaling complexes in beta 2-adrenergic receptor desensitization and resensitization | journal = The Journal of Biological Chemistry | volume = 275 | issue = 25 | pages = 19025–34 | date = June 2000 | pmid = 10858453 | doi = 10.1074/jbc.275.25.19025 | doi-access = free }}
  • {{cite journal | vauthors = McDonald PH, Chow CW, Miller WE, Laporte SA, Field ME, Lin FT, Davis RJ, Lefkowitz RJ | title = Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3 | journal = Science | volume = 290 | issue = 5496 | pages = 1574–7 | date = November 2000 | pmid = 11090355 | doi = 10.1126/science.290.5496.1574 | bibcode = 2000Sci...290.1574M }}
  • {{cite journal | vauthors = Luttrell LM, Roudabush FL, Choy EW, Miller WE, Field ME, Pierce KL, Lefkowitz RJ | title = Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 5 | pages = 2449–54 | date = February 2001 | pmid = 11226259 | pmc = 30158 | doi = 10.1073/pnas.041604898 | bibcode = 2001PNAS...98.2449L | doi-access = free }}
  • {{cite journal | vauthors = Cen B, Yu Q, Guo J, Wu Y, Ling K, Cheng Z, Ma L, Pei G | title = Direct binding of beta-arrestins to two distinct intracellular domains of the delta opioid receptor | journal = Journal of Neurochemistry | volume = 76 | issue = 6 | pages = 1887–94 | date = March 2001 | pmid = 11259507 | doi = 10.1046/j.1471-4159.2001.00204.x | s2cid = 83485138 | doi-access = free }}
  • {{cite journal | vauthors = Oakley RH, Laporte SA, Holt JA, Barak LS, Caron MG | title = Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis* | journal = The Journal of Biological Chemistry | volume = 276 | issue = 22 | pages = 19452–60 | date = June 2001 | pmid = 11279203 | doi = 10.1074/jbc.M101450200 | doi-access = free }}
  • {{cite journal | vauthors = Miller WE, McDonald PH, Cai SF, Field ME, Davis RJ, Lefkowitz RJ | title = Identification of a motif in the carboxyl terminus of beta -arrestin2 responsible for activation of JNK3 | journal = The Journal of Biological Chemistry | volume = 276 | issue = 30 | pages = 27770–7 | date = July 2001 | pmid = 11356842 | doi = 10.1074/jbc.M102264200 | doi-access = free }}
  • {{cite journal | vauthors = Claing A, Chen W, Miller WE, Vitale N, Moss J, Premont RT, Lefkowitz RJ | title = beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis | journal = The Journal of Biological Chemistry | volume = 276 | issue = 45 | pages = 42509–13 | date = November 2001 | pmid = 11533043 | doi = 10.1074/jbc.M108399200 | doi-access = free }}
  • {{cite journal | vauthors = Hilairet S, Bélanger C, Bertrand J, Laperrière A, Foord SM, Bouvier M | title = Agonist-promoted internalization of a ternary complex between calcitonin receptor-like receptor, receptor activity-modifying protein 1 (RAMP1), and beta-arrestin | journal = The Journal of Biological Chemistry | volume = 276 | issue = 45 | pages = 42182–90 | date = November 2001 | pmid = 11535606 | doi = 10.1074/jbc.M107323200 | doi-access = free }}
  • {{cite journal | vauthors = Shenoy SK, McDonald PH, Kohout TA, Lefkowitz RJ | title = Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin | journal = Science | volume = 294 | issue = 5545 | pages = 1307–13 | date = November 2001 | pmid = 11588219 | doi = 10.1126/science.1063866 | bibcode = 2001Sci...294.1307S | s2cid = 23486946 | doi-access = free }}
  • {{cite journal | vauthors = Chen Z, Dupré DJ, Le Gouill C, Rola-Pleszczynski M, Stanková J | title = Agonist-induced internalization of the platelet-activating factor receptor is dependent on arrestins but independent of G-protein activation. Role of the C terminus and the (D/N)PXXY motif | journal = The Journal of Biological Chemistry | volume = 277 | issue = 9 | pages = 7356–62 | date = March 2002 | pmid = 11729201 | doi = 10.1074/jbc.M110058200 | doi-access =free }}

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External links

  • {{UCSC gene info|ARRB2}}

{{NLM content}}

{{Membrane proteins}}

Category:Genes

Category:Human proteins