ATF/CREB

{{Short description|Group of transcription factors}}

The ATF/CREB family is a group of transcription factors, consisting of different ATFs (Activating transcription factors), CREB (cAMP response element binding protein), CREM (cAMP response element modulator) and related proteins.[http://www.pnas.org/content/91/12/5647.full.pdf Targeted mutation of the CREB gene: Compensation within the CREB/ATF family of transcription factors] EDITH HUMMLER, TIMOTHY J. COLE, JULIE A. BLENDY, RUTH GANSS, ADRIANO AGUZZII, WOLFGANG SCHMID, FRIEDRICH BEERMANN, AND GÜNTHER SCHÜTZ Proc. Nati. Acad. Sci. USA. Vol. 91, pp. 5647-5651, June 1994, Biochemistry{{cite journal |author=Karin M1, Smeal T |title=Control of transcription factors by signal transduction pathways: the beginning of the end |journal= Trends Biochem Sci|volume=17 |issue=10 |pages=418–22 |year=1992 |pmid= 1455510 |doi=10.1016/0968-0004(92)90012-x}} Among the transcription factors assigned to this group, some are more related to CREB-like, factors, whereas other exhibit closer similarity with the AP-1 transcription factor components c-Jun or c-Fos.{{cite web | title = Classification of Human Transcription Factors (TFClass) | url = http://tfclass.bioinf.med.uni-goettingen.de/tfclass | archive-url = https://web.archive.org/web/20140407072323/http://tfclass.bioinf.med.uni-goettingen.de/tfclass | archive-date = 2014-04-07 | url-status = dead }}

Common features are a basic leucine zipper type of DNA-binding domain and binding as a dimer to

DNA sequences like 5'-TGACGTCA-3' or 5'-TGA(C/G)TCA-3' as recognition sequences.{{cite book |author=Walter F., PhD. Boron |title=Medical Physiology: A Cellular And Molecular Approach |publisher=Elsevier/Saunders |year=2003 |pages=125–126 |isbn=1-4160-2328-3 }}