ATF5

First described by Nishizawa and Nagata,{{cite journal | vauthors = Pati D, Meistrich ML, Plon SE | title = Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis | journal = Mol. Cell. Biol. | volume = 19 | issue = 7 | pages = 5001–13 | date = July 1999 | pmid = 10373550 | pmc = 84326 | doi = 10.1128/mcb.19.7.5001}} ATF5 has been classified as a member of the activating transcription factor (ATF)/cAMP response-element binding protein (CREB) family.{{cite journal | vauthors = Hai T, Hartman MG | title = The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis | journal = Gene | volume = 273 | issue = 1 | pages = 1–11 | date = July 2001 | pmid = 11483355 | doi = 10.1016/S0378-1119(01)00551-0 }}{{cite journal | vauthors = Vinson C, Myakishev M, Acharya A, Mir AA, Moll JR, Bonovich M | title = Classification of human B-ZIP proteins based on dimerization properties | journal = Mol. Cell. Biol. | volume = 22 | issue = 18 | pages = 6321–6335 | date = September 2002 | pmid = 12192032 | pmc = 135624 | doi = 10.1128/MCB.22.18.6321-6335.2002 }}

ATF5 transcripts and protein are expressed in a wide variety of tissues, in particular, high expression of transcripts in liver. It is also present in a variety of tumor cell types.

ATF5 expression is regulated at both the transcriptional and translational level.

ATF5 is expressed in VZ and SVZ during brain development.

The human ATF5 protein is made up of 282 amino acids.

ATF5 is a transcription factor that contains a bZip domain.

• Activating transcription factor

ATF5 has been shown to interact with DISC1{{cite journal | vauthors = Morris JA, Kandpal G, Ma L, Austin CP | title = DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation | journal = Hum. Mol. Genet. | volume = 12 | issue = 13 | pages = 1591–1608 | date = Jul 2003 | pmid = 12812986 | doi = 10.1093/hmg/ddg162 | doi-access = }} and TRIB3.{{cite journal | vauthors = Zhou Y, Li L, Liu Q, Xing G, Kuai X, Sun J, Yin X, Wang J, Zhang L, He F | title = E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3 | journal = Cell. Signal. | volume = 20 | issue = 5 | pages = 942–948 | date = May 2008 | pmid = 18276110 | doi = 10.1016/j.cellsig.2008.01.010 }}

{{reflist}}

{{refbegin | 2}}

• {{cite journal | vauthors = Pati D, Meistrich ML, Plon SE | title = Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis | journal = Mol. Cell. Biol. | volume = 19 | issue = 7 | pages = 5001–13 | year = 1999 | pmid = 10373550 | pmc = 84326 | doi = 10.1128/mcb.19.7.5001}}
• {{cite journal | vauthors = White JH, McIllhinney RA, Wise A, Ciruela F, Chan WY, Emson PC, Billinton A, Marshall FH | title = The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 25 | pages = 13967–13972 | year = 2001 | pmid = 11087824 | pmc = 17684 | doi = 10.1073/pnas.240452197 | doi-access = free | bibcode = 2000PNAS...9713967W }}
• {{cite journal | vauthors = Peters CS, Liang X, Li S, Kannan S, Peng Y, Taub R, Diamond RH | title = ATF-7, a novel bZIP protein, interacts with the PRL-1 protein-tyrosine phosphatase | journal = J. Biol. Chem. | volume = 276 | issue = 17 | pages = 13718–26 | year = 2001 | pmid = 11278933 | doi = 10.1074/jbc.M011562200 | doi-access = free }}
• {{cite journal | vauthors = Morris JA, Kandpal G, Ma L, Austin CP | title = DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation | journal = Hum. Mol. Genet. | volume = 12 | issue = 13 | pages = 1591–1608 | year = 2004 | pmid = 12812986 | doi = 10.1093/hmg/ddg162 | doi-access = }}
• {{cite journal | vauthors = Yamada S, Ohira M, Horie H, Ando K, Takayasu H, Suzuki Y, Sugano S, Hirata T, Goto T, Matsunaga T, Hiyama E, Hayashi Y, Ando H, Suita S, Kaneko M, Sasaki F, Hashizume K, Ohnuma N, Nakagawara A | title = Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas | journal = Oncogene | volume = 23 | issue = 35 | pages = 5901–5911 | year = 2004 | pmid = 15221005 | doi = 10.1038/sj.onc.1207782 | doi-access = | s2cid = 3114318 }}
• {{cite journal | vauthors = Liu W, Sun M, Jiang J, Shen X, Sun Q, Liu W, Shen H, Gu J | title = Cyclin D3 interacts with human activating transcription factor 5 and potentiates its transcription activity | journal = Biochem. Biophys. Res. Commun. | volume = 321 | issue = 4 | pages = 954–960 | year = 2004 | pmid = 15358120 | doi = 10.1016/j.bbrc.2004.07.053 }}
• {{cite journal | vauthors = Forgacs E, Gupta SK, Kerry JA, Semmes OJ | title = The bZIP transcription factor ATFx binds human T-cell leukemia virus type 1 (HTLV-1) Tax and represses HTLV-1 long terminal repeat-mediated transcription | journal = J. Virol. | volume = 79 | issue = 11 | pages = 6932–6939 | year = 2005 | pmid = 15890932 | pmc = 1112100 | doi = 10.1128/JVI.79.11.6932-6939.2005 }}
• {{cite journal | vauthors = Al Sarraj J, Vinson C, Thiel G | title = Regulation of asparagine synthetase gene transcription by the basic region leucine zipper transcription factors ATF5 and CHOP | journal = Biol. Chem. | volume = 386 | issue = 9 | pages = 873–879 | year = 2005 | pmid = 16164412 | doi = 10.1515/BC.2005.102 | s2cid = 24061972 }}
• {{cite journal | vauthors = Angelastro JM, Canoll PD, Kuo J, Weicker M, Costa A, Bruce JN, Greene LA | title = Selective destruction of glioblastoma cells by interference with the activity or expression of ATF5 | journal = Oncogene | volume = 25 | issue = 6 | pages = 907–916 | year = 2006 | pmid = 16170340 | doi = 10.1038/sj.onc.1209116 | doi-access = | s2cid = 19581052 }}
• {{cite journal | vauthors = Wei Y, Jiang J, Sun M, Chen X, Wang H, Gu J | title = ATF5 increases cisplatin-induced apoptosis through up-regulation of cyclin D3 transcription in HeLa cells | journal = Biochem. Biophys. Res. Commun. | volume = 339 | issue = 2 | pages = 591–596 | year = 2006 | pmid = 16300731 | doi = 10.1016/j.bbrc.2005.11.054 }}
• {{cite journal | vauthors = Kakiuchi C, Ishiwata M, Nanko S, Kunugi H, Minabe Y, Nakamura K, Mori N, Fujii K, Yamada K, Yoshikawa T, Kato T | title = Association analysis of ATF4 and ATF5, genes for interacting-proteins of DISC1, in bipolar disorder | journal = Neurosci. Lett. | volume = 417 | issue = 3 | pages = 316–321 | year = 2007 | pmid = 17346882 | doi = 10.1016/j.neulet.2007.02.054 | s2cid = 7488805 }}
• {{cite journal | vauthors = Watatani Y, Ichikawa K, Nakanishi N, Fujimoto M, Takeda H, Kimura N, Hirose H, Takahashi S, Takahashi Y | title = Stress-induced translation of ATF5 mRNA is regulated by the 5'-untranslated region | journal = J. Biol. Chem. | volume = 283 | issue = 5 | pages = 2543–2553 | year = 2008 | pmid = 18055463 | doi = 10.1074/jbc.M707781200 | doi-access = free }}

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• {{MeshName|ATF5+protein,+human}}
• {{UCSC gene info|ATF5}}

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{{Transcription factors|g1}}

{{Regulome

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Category:Transcription factors

Category:Biology of bipolar disorder

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