Amlodipine/benazepril

{{Short description|Antihypertensive medication}}

{{Use dmy dates|date=February 2024}}

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| verifiedrevid = 415479203

| type = combo

| image = Amlodipine.svg

| alt =

| image2 = Benazepril.svg

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| component1 = Amlodipine

| class1 = Calcium channel blocker

| component2 = Benazepril

| class2 = ACE inhibitor

| tradename = Lotrel

| Drugs.com = {{drugs.com|ppa|amlodipine-and-benazepril}}

| DailyMedID = Amlodipine and benazepril

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| routes_of_administration = By mouth

| ATC_prefix = C09

| ATC_suffix = BB13

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| legal_US = Rx-only

| legal_US_comment = {{cite web | title=Lotrel- amlodipine besylate and benazepril hydrochloride capsule | work = DailyMed | publisher = U.S. National Library of Medicine | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=94ae6054-b7ae-4212-a567-4f803af8f2c7 | access-date=20 June 2021}}

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| CAS_number_Ref = {{cascite|changed|??}}

| CAS_number = 357437-90-2

| PubChem = 5746247

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| ChemSpiderID = 4676979

| KEGG = D11069

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Amlodipine/benazepril, sold under the brand name Lotrel among others, is a fixed-dose combination medication used to treat high blood pressure. It is a combination of amlodipine, as the besilate, a calcium channel blocker, and benazepril, an angiotensin converting enzyme inhibitor. It may be used if a single agent is not sufficient. It is taken by mouth.

Common side effects include cough, dizziness, and swelling. Serious side effects may include angioedema, myocardial infarction, high blood potassium, liver problems, and low blood pressure. Use in pregnancy is not recommended. Amlodipine works by increasing the size of arteries while benazepril works by decreasing renin-angiotensin-aldosterone system activity.

The combination was approved for medical use in the United States in 1995.{{cite web | author = Cerner Multum |title=Amlodipine and benazepril Uses, Side Effects & Warnings |url=https://www.drugs.com/mtm/amlodipine-and-benazepril.html |website=Drugs.com |access-date=10 March 2019 |language=en}} It is available as a generic medication.{{cite book | vauthors = Bope ET, Kellerman RD |title=Conn's Current Therapy 2017 E-Book |date=2016 |publisher=Elsevier Health Sciences |isbn=978-0-323-44335-7 |page=124 |url=https://books.google.com/books?id=UitFDQAAQBAJ&pg=PT158 }} In 2022, it was the 170th most commonly prescribed medication in the United States, with more than 3{{nbsp}}million prescriptions.{{cite web | title=The Top 300 of 2022 | url=https://clincalc.com/DrugStats/Top300Drugs.aspx | website=ClinCalc | access-date=30 August 2024 | archive-date=30 August 2024 | archive-url=https://web.archive.org/web/20240830202410/https://clincalc.com/DrugStats/Top300Drugs.aspx | url-status=live }}{{cite web | title = Amlodipine; Benazepril Drug Usage Statistics, United States, 2013 - 2022 | website = ClinCalc | url = https://clincalc.com/DrugStats/Drugs/AmlodipineBenazepril | access-date = 30 August 2024 }}